Silver and Alginates: Role in Wound Healing and Biofilm Control

Percival, Steven L.; McCarty, Sara

doi:10.1089/wound.2014.0541

Cited by 69 publications

(61 citation statements)

References 48 publications

(51 reference statements)

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“…1,45 Management of wound dressings containing antibacterial agents is expected to be a feasible way to solve the problem. 1 However, improper use of antibiotics has led to serious antibiotic resistance problem, so it is necessary to find an alternative approach. To meet this demand, a PCL nanofibrous mesh impregnated with NS nanocomposite was prepared using environmentally friendly and mussel-inspired DA in this work (Figure 1).…”

Section: Discussionmentioning

confidence: 99%

“…More importantly, PCL/NS1.0 and PCL/NS2.0 could also inhibit the formation of biofilms (Figure 6), which is essential for a wound dressing in practical application. 1 This may be because that NS-containing biomaterials could fight bacterial adhesion and clonal growth. 30,47 Although the bactericidal mechanisms of NS are not fully understood, 8 a possible explanation for the excellent antibacterial activities of PCL/NS1.0 and PCL/NS2.0 could be speculated based on previous reports and our results as follows: NSs have nanodimensions of 1-100 nm and large surface-to-volume ratio.…”

Section: Discussionmentioning

confidence: 99%

“…41,42 Therefore, it is important for a wound dressing to inhibit the formation of biofilms when covered on the wound. 1 To further investigate the formation of biofilms on the surfaces of PCL, PCL/DA, PCL/NS0.5, PCL/NS1.0 and PCL/NS2.0 films, the samples after co-incubation with bacteria were observed by SEM, and the areas covered by biofilms or bacteria were measured. As shown in Figure 6, extensive bacterial colonization produced by the proliferation of S. aureus, E. coli or A. baumannii was grouped on the surfaces of PCL, PCL/DA and PCL/NS0.5 films, and partial bacteria were encased in the polymeric matrix, which suggested the formation of biofilms.…”

Section: In Vitro Antibacterial Property Of Pcl/nsmentioning

confidence: 99%

“…[1][2][3] Antibiotics are generally used to provide the antibacterial activity in the clinical setting, but their overuse has caused antibiotic resistance to bacterial pathogens, which further led to the emergence of multidrug-resistant (MDR) bacteria. 4,5 Thus, an alternative solution is urgently needed.…”

Section: Introductionmentioning

confidence: 99%

“…59 The active keratinocyte proliferation and fast re-epithelialization are important for the new tissue regeneration, while the bacterial infection is the main cause of impaired healing. 1,59,60 Wound dressings impregnated with antimicrobials can prevent local bacterial infection and maintain the natural microenvironment for cell proliferation and tissue regeneration to promote wound healing. 3,61 As described earlier, compared with the control, PCL and PCL/DA groups, the biocompatible PCL/NS1.0 was efficient to protect the wounds from bacterial infection ( Figure 9) and maintain a natural and aseptic wound microenvironment without severe inflammation response to promote keratinocyte proliferation (Figures 11 and 12).…”

mentioning

confidence: 99%

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Optimization and integration of nanosilver on polycaprolactone nanofibrous mesh for bacterial inhibition and wound healing in vitro and in vivo

Liu¹,

Luo²,

Wang³

et al. 2017

IJN

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Bacterial infection is a major hurdle to wound healing, and the overuse of antibiotics have led to global issue, such as emergence of multidrug-resistant bacteria, even “super bacteria”. On the contrary, nanosilver (NS) can kill bacteria without causing resistant bacterial strains. In this study, NS was simply generated in situ on the polycaprolactone (PCL) nanofibrous mesh using an environmentally benign and mussel-inspired dopamine (DA). Scanning electron microscopy showed that NS uniformly formed on the nanofibers of PCL mesh. Fourier transform infrared spectroscopy revealed the step-by-step preparation of pristine PCL mesh, including DA coating and NS formation, which were further verified by water contact angle changing from hydrophobic to hydrophilic. To optimize the NS dose, the antibacterial activity of PCL/NS against Staphylococcus aureus , Escherichia coli and Acinetobacter baumannii was detected by bacterial suspension assay, and the cytotoxicity of NS was evaluated using cellular morphology observation and Cell Counting Kit-8 (CCK8) assay. Then, inductively coupled plasma atomic emission spectrometry exhibited that the optimized PCL/NS had a safe and sustained silver release. Moreover, PCL/NS could effectively inhibit bacterial infection in an infectious murine full-thickness skin wound model. As demonstrated by the enhanced level of proliferating cell nuclear antigen (PCNA) in keratinocytes and longer length of neo-formed epidermis, PCL/NS accelerated wound healing by promoting re-epithelialization via enhancing keratinocyte proliferation in infectious wounds.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: In Vitro Antibacterial Property Of Pcl/nsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Optimization and integration of nanosilver on polycaprolactone nanofibrous mesh for bacterial inhibition and wound healing in vitro and in vivo

Liu¹,

Luo²,

Wang³

et al. 2017

IJN

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Photo‐Crosslinked Antimicrobial Hydrogel Exhibiting Wound Healing Ability and Curing Infections In Vivo

Dey

Mukherjee

Haldar

2022

Adv Healthcare Materials

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With the increasing focus on healthcare research in the current times, therapeutic and biomaterial interventions for healing of wounds and mitigation of wound-associated infections have seen expedited progress. Conventional approaches consist of release-active gels, which demonstrate leaching of antimicrobials, such as antibiotics, metal ions, etc. However, these systems suffer from the disadvantages of burst release, reservoir exhaustion, and associated toxicity. In this report, intrinsically antimicrobial hydrogel (HyDex) is developed by one-pot UV crosslinking of methacrylated dextran, polyethylene glycol diacrylate, and cationic lipophilic methacrylate with varied hydrophobic chain, which displays broad-spectrum antimicrobial activity, hemostatic ability, and rapid wound closure efficacy. The optimized hydrogel exhibits potent antimicrobial efficacy against multidrug-resistant Gram-positive and Gram-negative bacteria as well as against pathogenic fungus Candida albicans. The HyDex hydrogel shows rapid arrest of bleeding in mice liver puncture model. The hydrogel kills carbapenem-resistant Acinetobacter baumannii in a murine model of burn wound infection with >99% reduction in bacterial burden. Furthermore, this hydrogel displays significant reduction in inflammatory responses, with accelerated wound healing in rat deep wound model. Collectively, these results imply the excellent promise held by lead hydrogel to be developed for tackling deep tissue wounds, notorious infections, and resulting inflammatory responses.

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Recent Advances of Halloysite Nanotubes in Biomedical Applications

Jiang,

Sun,

Liu

et al. 2023

Small

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Halloysite nanotubes (HNTs) have emerged as a highly regarded choice in biomedical research due to their exceptional attributes, including superior loading capacity, customizable surface characteristics, and excellent biocompatibility. HNTs feature tubular structures comprising alumina and silica layers, endowing them with a large surface area and versatile surface chemistries that facilitate selective modifications. Moreover, their substantial pore volume and wide range of pore sizes enable efficient entrapment of diverse functional molecules. This comprehensive review highlights the broad biomedical application spectrum of HNTs, shedding light on their potential as innovative and effective therapeutic agents across various diseases. It emphasizes the necessity of optimizing drug delivery techniques, developing targeted delivery systems, rigorously evaluating biocompatibility and safety through preclinical and clinical investigations, exploring combination therapies, and advancing scientific understanding. With further advancements, HNTs hold the promise to revolutionize the pharmaceutical industry, opening new avenues for the development of transformative treatments.

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Silver and Alginates: Role in Wound Healing and Biofilm Control

Cited by 69 publications

References 48 publications

Optimization and integration of nanosilver on polycaprolactone nanofibrous mesh for bacterial inhibition and wound healing in vitro and in vivo

Optimization and integration of nanosilver on polycaprolactone nanofibrous mesh for bacterial inhibition and wound healing in vitro and in vivo

Photo‐Crosslinked Antimicrobial Hydrogel Exhibiting Wound Healing Ability and Curing Infections In Vivo

Recent Advances of Halloysite Nanotubes in Biomedical Applications

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