Silodosin and its potential for treating premature ejaculation: A preliminary report

Sato, Yoshikazu; Tanda, Hitoshi; Nakajima, Hisao; Nitta, Toshikazu; Akagashi, Keigo; Hanzawa, Tatsuo; Tobe, Musashi; Haga, Kazunori; Uchida, Kazuhiko; Honma, Ichiya

doi:10.1111/j.1442-2042.2011.02941.x

Cited by 38 publications

(44 citation statements)

References 19 publications

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“…Anatomy studies demonstrate that the main sympathetic signals to the accessory sex gland consist of the lumbar splanchnic nerve, caudal mesenteric plexus, hypogastric nerve, pelvic plexus, and its branches (Kihara et al, 1998). Recently, some studies have found that the sympathetic pathway is mainly through the a1a receptor, and the a1a antagonist has therapeutic potentials for premature ejaculation (Cl ement et al, 2006;Sato et al, 2012;Hsieh et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Centrally mediated ejaculatory response via sympathetic outflow in rats: role of N‐methyl‐D‐aspartic acid receptors in paraventricular nucleus

et al. 2016

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SUMMARYEjaculation is mediated by a spinal generator, which integrates inputs related to the sexual activity and coordinates sympathetic, parasympathetic, and motor outflow. Previous clinical studies indicate that primary premature ejaculation is related to the hyperactivity of the sympathetic nervous system. In this study, we explored the roles of N-methyl-D-aspartic acid (NMDA) receptors in paraventricular nucleus of the hypothalamus (PVN) on ejaculatory responses and its potential mechanism in the rats. We found that microinjection of 0.20 nmol NMDA into the PVN reduced the latency of intromission and facilitated ejaculation during copulation. Moreover, delayed ejaculation and intromission were observed after the rats were microinjected with NMDA receptor antagonist D (À)-2-Amino-5-phosphonopentanoic acid (AP-5). However, we discovered that microinjection of NMDA into PVN significantly increased baseline lumbar splanchnic nerve activity (LSNA), and the NMDA dose was positively correlated with the increased LSNA (r = 0.875, p = 0.04). Meanwhile, the plasma norepinephrine level in rats injected with NMDA was much higher than that in rats injected with saline (1453.4 AE 136.4 pg/mL vs. 492.3 AE 36.8 pg/mL, p < 0.01). Additionally, AP-5 reduced the baseline LSNA and abrogated the enhancing activity of NMDA in LSNA. Thus, we propose that NMDA receptors in PVN may facilitate ejaculation through enhancing the activity of sympathetic system.

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Section: Discussionmentioning

confidence: 99%

Centrally mediated ejaculatory response via sympathetic outflow in rats: role of N‐methyl‐D‐aspartic acid receptors in paraventricular nucleus

et al. 2016

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“…The latter determine a relaxation of the smooth muscles of the prostate and urethra, and reduce vas contractility by competitive binding of postsynaptic α 1 A-adrenoceptors [7,8]. Other α-blockers, such as silodosin, could have higher selectivity than tamsulosin for α 1 A-adrenoceptors [7,8]. Nevertheless, since tamsulosin proved effective, we have left silodosin as a second option.…”

Section: Discussionmentioning

confidence: 99%

“…Consistently, the same painful sensation was reported after injection of contrast into the vas and symptoms improved after administration of α-blockers. The latter determine a relaxation of the smooth muscles of the prostate and urethra, and reduce vas contractility by competitive binding of postsynaptic α 1 A-adrenoceptors [7,8]. Other α-blockers, such as silodosin, could have higher selectivity than tamsulosin for α 1 A-adrenoceptors [7,8].…”

Section: Discussionmentioning

confidence: 99%

Painful Orgasm in an Adolescent after Seminal-Sparing Cystoprostatectomy: A Puzzling Symptom

Angelini¹,

Castagnetti²,

Rigamonti³

2014

Urol Int

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An 18-year-old boy, followed up after seminal-sparing cystectomy for bladder rhabdomyosarcoma, presented complaining of recurrent episodes of left scrotal/inguinal pain arising after orgasms. Full work-up ruled out disease recurrence, but showed enlarged seminal vesicles. Ligation of the vas deferens was unsuccessful. The patient was started on α-blockers to reduce vas contractions with improvement of symptoms. The possible pathophysiology and treatments of this symptom are discussed.

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“…Silodosin, a highly selective a1A-adrenoceptor antagonist has been shown to be effective for lower urinary tract symptoms (LUTS) when evaluated as a new treatment option for PE (Sato et al, 2012). Silodosin has been suggested as a novel therapy for PE but needs validation in controlled clinical trials (Sato et al, 2012).…”

Section: Alpha1-adrenoreceptor Antagonistsmentioning

confidence: 99%

“…Silodosin has been suggested as a novel therapy for PE but needs validation in controlled clinical trials (Sato et al, 2012).…”

Section: Alpha1-adrenoreceptor Antagonistsmentioning

confidence: 99%

The characterization, current medications, and promising therapeutics targets for premature ejaculation

Gür

Sikka

2015

Andrology

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SUMMARYPremature ejaculation (PE) is the most prevalent male sexual dysfunction. This is associated with negative personal and interpersonal psychological outcomes. The pharmacologic treatment of PE includes the use of antidepressants, local anesthetic agents, and phosphodiesterase type 5 inhibitors. While numerous treatments can control PE, only antidepressants and topical anesthetic creams and sprays have recently been shown to be more effective. This review focuses on the physiology and pharmacology of ejaculation, the pathophysiology of PE and the most effective pharmacological treatment of PE. Pharmacotherapy of PE with off-label shortacting selective serotonin reuptake inhibitors (SSRIs) is common, effective, and safe. Dapoxetine, a SSRI with a short half-life, has been recently evaluated for the treatment of PE by several countries and results are promising. In clinical practice, follow-up side effects are an important part of the management strategy for PE. The understanding of etiology, pathophysiology, and treatment modalities of PE would be beneficial to clinician in helping patients with this disappointing sexual problem.

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Silodosin and its potential for treating premature ejaculation: A preliminary report

Cited by 38 publications

References 19 publications

Centrally mediated ejaculatory response via sympathetic outflow in rats: role of N‐methyl‐D‐aspartic acid receptors in paraventricular nucleus

Centrally mediated ejaculatory response via sympathetic outflow in rats: role of N‐methyl‐D‐aspartic acid receptors in paraventricular nucleus

Painful Orgasm in an Adolescent after Seminal-Sparing Cystoprostatectomy: A Puzzling Symptom

The characterization, current medications, and promising therapeutics targets for premature ejaculation

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