Silkworm pupa protein and its peptides: Preparation, biological activity, applications in foods, and advantages

Wu, Xiaolin; Yang, Jing; Mumby, William; Zhang, Yuhong; Zhang, Yu; Wang, Chen; Chen, Xiaoyong; Suo, Huayi; Song, Jiajia

doi:10.1016/j.tifs.2023.104129

Cited by 7 publications

(1 citation statement)

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“…With the development of the food industry, many studies on edible insects have been carried out globally during the past 2 decades, including nutrient ingredient identification [3], nutritional value assessment [4], and further processing [5]. Numerous studies have confirmed that silkworm pupae possess excellent nutritional qualities and contain abundant nutrients, such as proteins, lipids, and vitamins; the protein includes a complete set of 18 amino acids, among which the essential amino acids account for over 55% [6].…”

Section: Introductionmentioning

confidence: 99%

The Protective Effects of Silkworm (Bombyx mori) Pupae Peptides on UV-Induced Skin Photoaging in Mice

Lin,

Fan,

et al. 2024

Foods

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Silkworm (Bombyx mori) pupae are popular edible insects with high nutritional and therapeutic value. Currently, there is growing interest in the comprehensive application of silkworm pupae. In this study, peptides that exhibited anti-photoaging activity were obtained from silkworm pupae protein, aiming to investigate the protective effects and potential mechanisms of silkworm pupae peptides (SPPs) on skin photoaging. The results showed that SPPs were composed of 900 short peptides and could effectively alleviate skin photoaging progression. They significantly eliminated excessive production of ROS and MDA; meanwhile, they also renovated the antioxidant enzyme activities. The biomarkers related to collagen synthesis and degradation, including hydroxyproline, interstitial collagenase, and gelatinase, demonstrated that SPPs could suppress collagen degradation. Histopathological results showed that SPPs could reduce the inflammatory infiltrate and the thickness of the dermis and epidermis, as well as increase the collagen bundles and muscle fibers. The histopathological and biochemical results confirmed that SPPs could alleviate photoaging by inhibiting abnormal skin changes, reducing oxidative stress, and immune suppression. Overall, these data prove the protective effects of SPPs against the photoaging process, suggesting their potential as an active ingredient in skin photoaging prevention and therapy.

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