Silk protein sericin: a promising therapy for Achilles tendinopathy—evidence from an experimental rat model

Sayin, Dilek; Gundogdu, Gulsah; Kilic-Erkek, Ozgen; Gundogdu, Koksal; Coban, Hatice Siyzen; Abban-Mete, Gulcin

doi:10.1007/s10067-023-06767-6

Cited by 3 publications

(1 citation statement)

References 49 publications

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“…Nanomedicine has emerged, offering potential solutions to the treatment of different conditions in relation to using silk-based materials, such as osteoarthritis treatment [ 129 ], or Achilles tendinopathy [ 157 ]. Research with gold nanoparticles in silk hydrogel used as a media for the laser treatment of subcutaneous bacterial abscesses has shown promising results for this complex medical condition [ 158 ].…”

Section: Spider Silk In Nanomedicinementioning

confidence: 99%

Review of Spider Silk Applications in Biomedical and Tissue Engineering

Branković,

Zivic,

Grujovic

et al. 2024

Biomimetics

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This review will present the latest research related to the production and application of spider silk and silk-based materials in reconstructive and regenerative medicine and tissue engineering, with a focus on musculoskeletal tissues, and including skin regeneration and tissue repair of bone and cartilage, ligaments, muscle tissue, peripheral nerves, and artificial blood vessels. Natural spider silk synthesis is reviewed, and the further recombinant production of spider silk proteins. Research insights into possible spider silk structures, like fibers (1D), coatings (2D), and 3D constructs, including porous structures, hydrogels, and organ-on-chip designs, have been reviewed considering a design of bioactive materials for smart medical implants and drug delivery systems. Silk is one of the toughest natural materials, with high strain at failure and mechanical strength. Novel biomaterials with silk fibroin can mimic the tissue structure and promote regeneration and new tissue growth. Silk proteins are important in designing tissue-on-chip or organ-on-chip technologies and micro devices for the precise engineering of artificial tissues and organs, disease modeling, and the further selection of adequate medical treatments. Recent research indicates that silk (films, hydrogels, capsules, or liposomes coated with silk proteins) has the potential to provide controlled drug release at the target destination. However, even with clear advantages, there are still challenges that need further research, including clinical trials.

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Section: Spider Silk In Nanomedicinementioning

confidence: 99%

Review of Spider Silk Applications in Biomedical and Tissue Engineering

Branković,

Zivic,

Grujovic

et al. 2024

Biomimetics

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The impact of sericin on inflammation, oxidative stress, and lipid metabolism in female rats with experimental knee osteoarthritis

Gundogdu,

Kilic-Erkek,

Gundogdu

2024

Clin Rheumatol

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Investigation of The Efficacy of Sericin in Experimental Knee Osteoarthritis Model in Rats through the TGF-Beta/Smad Pathway

Gundogdu,

Kılıç Erkek,

Gündoğdu

et al. 2024

Veterinary Sciences and Practices

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OBJECTIVE: This study investigates the therapeutic efficacy of sericin in rats with knee osteoarthritis (KOA) induced with monosodium iodoacetate (MIA), focusing on evaluating its effectiveness through the TGF-β/Smad pathway. MATERIALS AND METHODS: The KOA model was established by injecting MIA into the knee joint and the rats were randomly divided into three groups:group 1 (control), group 2 (KOA control), and group 3 (KOA+sericin). Sericin was administered intratendinously to rats on days 1,7,14, and 21 (50 µL,0.8 g/kg/mL). After 21 days, the rats were sacrificed, and serum samples were analyzed using the ELISA method to measure TGF-β1, Smad2, and CTGF levels. Additionally, knee joint samples underwent histopathological evaluations with hematoxylin-eosin staining and immunohistochemical assessment using TGF-β1 and Smad2/3 antibodies. RESULTS: Serum TGF-β1 and CTGF levels were significantly increased in group 2 vs. group 1 (P

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Silk protein sericin: a promising therapy for Achilles tendinopathy—evidence from an experimental rat model

Cited by 3 publications

References 49 publications

Review of Spider Silk Applications in Biomedical and Tissue Engineering

Review of Spider Silk Applications in Biomedical and Tissue Engineering

The impact of sericin on inflammation, oxidative stress, and lipid metabolism in female rats with experimental knee osteoarthritis

Investigation of The Efficacy of Sericin in Experimental Knee Osteoarthritis Model in Rats through the TGF-Beta/Smad Pathway

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