Silk peptide-hyaluronic acid based nanogels for the enhancement of the topical administration of curcumin

Abstract

The present study focused on the development of Cur-loaded SOHA nanogels (Cur-SHNGs) to enhance the topical administration of Cur. The physiochemical properties of Cur-SHNGs were characterized. Results showed that the morphology of the Cur-SHNGs was spherical, the average size was 171.37 nm with a zeta potential of −13.23 mV. Skin permeation experiments were carried out using the diffusion cell systems. It was found that the skin retention of Cur-SHNGs was significantly improved since it showed the best retention value (0.66 ± 0.17 μg/cm2). In addition, the hematoxylin and eosin staining showed that the Cur-SHNGs improved transdermal drug delivery by altering the skin microstructure. Fluorescence imaging indicated that Cur-SHNGs could effectively deliver the drug to the deeper layers of the skin. Additionally, Cur-SHNGs showed significant analgesic and anti-inflammatory activity with no skin irritation. Taken together, Cur-SHNGs could be effectively used for the topical delivery of therapeutic drugs.

Microemulsion-Based Keratin–Chitosan Gel for Improvement of Skin Permeation/Retention and Activity of Curcumin

“…In general, when the particle size is less than 300 nm, the total surface area of the particle in contact with the skin is larger, and the drug has a greater chance to transfer into the skin, so it can easily penetrate the stratum corneum [32]. However, when the particle size is less than 100 nm, it is easier to penetrate into the systemic circulation through the skin, while when the particle size is more than 100 nm, it is easy to form a drug reservoir in the skin to increase the retention of drugs [33]. The particle size of CME-KCS gel is between 100 and 300 nm.…”

Hyaluronic Acid Nanogels: A Promising Platform for Therapeutic and Theranostic Applications

“…Several studies have explored the incorporation of HA into nanogel formulations for wound healing applications, leveraging HA’s inherent properties in skin regeneration. HA has been covalently conjugated onto various polymer backbones, including silk fibroin and polylactic acid, resulting in nanogels capable of encapsulating bioactive agents for dermatological applications, such as curcumin and verteporfin, respectively [ 34 , 135 ]. The presence of HA in the nanogel composition can augment the wound healing process and enhance skin penetration of the entrapped drugs to deeper layers.…”

“…The self-assembly of amphipathic HA into nanogels is driven by hydrophobic interactions, resulting in polymeric micelles in water. A variety of hydrophobic molecules have been trialed for this purpose, including linear alkyl chains [28][29][30][31][32][33][34], bulky hydrophobic molecules (e.g., cholesterol [35][36][37], pyrene [38,39], cholanic acid [40][41][42], and indocyanine green [43]), and hydrophobic polymers (e.g., ethylene glycol [44,45], polycaprolactone or PCL [46,47], poly(lactic-co-glycolic acid) or PLGA [48], and poly(N-isopropylacrylamide) or pNIPAM [49]. Additionally, HA can be covalently conjugated with metal-chelating functional groups, such as histidine amino acids and chelating agents such as iminodiacetic acid and malonic acid.…”

Dipeptide-1 modified nanostructured lipid carrier-based hydrogel with enhanced skin retention and topical efficacy of curcumin

“…Then the skin samples were respectively cut into pieces with scissor and immersed in 2 mL methanol for 24 h at 4 °C, subsequently placed in an ultrasound bath (KQ-250DE, Kunshan, China) for 3 h. Then it was refrigerated centrifuged at 10 000 rpm for 10 min and the supernatant was ltered by a syringe with a Millipore lter (0.22 mm). 7,25 The ltrate was analysed using the same HPLC method described above, and the cumulative amount of CUR retained in the skin per unit area was calculated.…”

“…Nanoparticle-based drug delivery systems have been increasingly exploited to encapsulate and deliver CUR, including liposomes, nanoemulsions, polymeric micelles and lipid nanoparticles. [7][8][9] Nanostructured lipid carrier (NLC), an advanced and second-generation lipid colloidal system, is mainly composed of solid lipid, liquid lipid and surfactants. 10 Because the crystal of solid lipid is disrupted by liquid lipid to form a lattice defects, NLC has an imperfect lipid matrix that offers more space for drug entrapment and prevents drug expulsion during storage.…”