2010
DOI: 10.1016/j.biomaterials.2009.11.002
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Silk nanospheres and microspheres from silk/pva blend films for drug delivery

Abstract: Silk fibroin protein-based micro-and nanospheres provide new options for drug delivery due to their biocompatibility, biodegradability and their tunable drug loading and release properties. In the present study, we report a new aqueous-based preparation method for silk spheres with controllable sphere size and shape. The preparation was based on phase separation between silk fibroin and polyvinyl alcohol (PVA) at a weight ratio of 1/1 and 1/4. Water-insoluble silk spheres were easily obtained from the blend in… Show more

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Cited by 378 publications
(290 citation statements)
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“…[30] It can be dissolved and easily reformed into various morphologies resulting from self-assembly. [31][32][33][34][35] This recombined silk fibroin (RSF) can be further transformed into a nanostructured, nitrogen-doped, carbon-based material via a simple pyrolysis process. [5] The fabrication process of the UTH-CNs is shown in Figure 1.…”
Section: Resultsmentioning
confidence: 99%
“…[30] It can be dissolved and easily reformed into various morphologies resulting from self-assembly. [31][32][33][34][35] This recombined silk fibroin (RSF) can be further transformed into a nanostructured, nitrogen-doped, carbon-based material via a simple pyrolysis process. [5] The fabrication process of the UTH-CNs is shown in Figure 1.…”
Section: Resultsmentioning
confidence: 99%
“…PVA is a nontoxic, biodegradable, synthetic, water-soluble polymer with outstanding chemical stability and good film-forming capacity [18,19]. PVA-protein films are produced as materials for food packing, tissue engineering, and drug delivery systems [20][21][22][23]. PVA hydrogel materials containing keratin from wool and hair were recently synthesized by electron beam irradiation [24].…”
Section: Introductionmentioning
confidence: 99%
“…The experiments involved three steps: (1) vaporization and removal of moisture in beads (to 100 °C), (2) material decomposition (at a different range for each case), and (3) thermal degradation and carbonization of the compounds (375 °C for all cases). In the case of SF samples, they presented a loss mass related to the breakdown of peptide bonds and side-chains of the residual amino acids [14,36].…”
Section: Thermal Characterizationmentioning
confidence: 99%
“…However, to be successfully used these materials should be modified to improve different properties, such as in-vivo stability, biocompatibility, biodegradability, and potential interaction with cells. For that, the scaffolds should also have a cell-friendly surface, and interconnected pores for the transport of cells, nutrients, and metabolites [2].…”
Section: Introductionmentioning
confidence: 99%