Silk-functionalized titanium surfaces for enhancing osteoblast functions and reducing bacterial adhesion

Zhang, Fan; Zhang, Zhengbiao; Zhu, Xiaomin; Kang, En‐Tang; Neoh, K. G.

doi:10.1016/j.biomaterials.2008.08.043

Cited by 185 publications

(158 citation statements)

References 36 publications

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“…Non-fouling surfaces combine one or more approaches in order to influence the amount and/or conformation of adsorbed proteins, preventing bacterial adhesion and biofilm formation. Some examples are UV radiation of titanium surfaces to augment wettability [27], use of anti-adherent agents bearing negative charges [28], polymer coatings such as poly(ethylene glycol) (PEG), poly(hydroxyethylmethacrylate) (PHEMA) [18,29], poly(methacrylic acid) [30], polyurethanes [31] or even bioactive polymers such as chitosan, which possess the ability to inhibit bacterial adhesion and/or to kill adherent bacteria [32]. Unfortunately, the effectiveness of non-fouling coatings for reducing bacterial adhesion is limited and varies greatly depending on bacterial species.…”

Section: Antimicrobial Coatingsmentioning

confidence: 99%

Covalent immobilization of antimicrobial peptides (AMPs) onto biomaterial surfaces

et al. 2011

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a b s t r a c tBacterial adhesion to biomaterials remains a major problem in the medical devices field. Antimicrobial peptides (AMPs) are well-known components of the innate immune system that can be applied to overcome biofilm-associated infections. Their relevance has been increasing as a practical alternative to conventional antibiotics, which are declining in effectiveness. The recent interest focused on these peptides can be explained by a group of special features, including a wide spectrum of activity, high efficacy at very low concentrations, target specificity, anti-endotoxin activity, synergistic action with classical antibiotics, and low propensity for developing resistance. Therefore, the development of an antimicrobial coating with such properties would be worthwhile. The immobilization of AMPs onto a biomaterial surface has further advantages as it also helps to circumvent AMPs' potential limitations, such as short half-life and cytotoxicity associated with higher concentrations of soluble peptides. The studies discussed in the current review report on the impact of covalent immobilization of AMPs onto surfaces through different chemical coupling strategies, length of spacers, and peptide orientation and concentration. The overall results suggest that immobilized AMPs may be effective in the prevention of biofilm formation by reduction of microorganism survival post-contact with the coated biomaterial. Minimal cytotoxicity and longterm stability profiles were obtained by optimizing immobilization parameters, indicating a promising potential for the use of immobilized AMPs in clinical applications. On the other hand, the effects of tethering on mechanisms of action of AMPs have not yet been fully elucidated. Therefore, further studies are recommended to explore the real potential of immobilized AMPs in health applications as antimicrobial coatings of medical devices.

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Section: Antimicrobial Coatingsmentioning

confidence: 99%

Covalent immobilization of antimicrobial peptides (AMPs) onto biomaterial surfaces

et al. 2011

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“…For example, mixtures of polyethylene oxide and proteinrepelling polyethylene glycol have shown significant bacterial inhibition when applied implant surfaces [66,67] . Singh et al [68] demonstrated that modifying surface roughness (Figures 7 [69] and 8) of a material at the nanoscale level could provide antibacterial properties.…”

Section: Modified Surface Characteristicsmentioning

confidence: 99%

Antimicrobial technology in orthopedic and spinal implants

Eltorai

Haglin

Perera

et al. 2016

WJO

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Infections can hinder orthopedic implant function and retention. Current implant-based antimicrobial strategies largely utilize coating-based approaches in order to reduce biofilm formation and bacterial adhesion. Several emerging antimicrobial technologies that integrate a multidisciplinary combination of drug delivery systems, material science, immunology, and polymer chemistry are in development and early clinical use. This review outlines orthopedic implant antimicrobial technology, its current applications and supporting evidence, and clinically promising future directions.Key words: Antimicrobial; Coated implants; Antibiotic; Antiseptic; Nano-silver; Photoactive Core tip: Infections can hinder orthopedic implant function and retention. Current implant-based antimicrobial strategies largely utilize coating-based approaches in order to reduce biofilm formation and bacterial adhesion. Several emerging antimicrobial technologies that integrate a multidisciplinary combination of drug delivery systems, material science, immunology, and polymer chemistry are in development and early clinical use. This review outlines the latest orthopedic implant antimicrobial technologies-including updates on chitosan

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“…Ti with (P(MAA)) followed by immobilization of silk sericin (Zhang et al, 2008) S. aureus Ti, Ta, Cr and DLC surfaces (Levon et al, 2009) …”

Section: S Aureus S Epidermidismentioning

confidence: 99%

Oral Bacterial Adhesion and Biocompatibility of Silver-Amorphous Carbon Films: A Surface Modification for Dental Implants

Almaguer-Flore¹,

Rodil²,

Olivares-Navarrete³

2011

Implant Dentistry - The Most Promising Discipline of Dentistry

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Silk-functionalized titanium surfaces for enhancing osteoblast functions and reducing bacterial adhesion

Cited by 185 publications

References 36 publications

Covalent immobilization of antimicrobial peptides (AMPs) onto biomaterial surfaces

Covalent immobilization of antimicrobial peptides (AMPs) onto biomaterial surfaces

Antimicrobial technology in orthopedic and spinal implants

Oral Bacterial Adhesion and Biocompatibility of Silver-Amorphous Carbon Films: A Surface Modification for Dental Implants

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