Silk Fibroin Microneedle Patches for the Sustained Release of Levonorgestrel

Yavuz, Burçin; Chambre, Laura; Harrington, K.; Kluge, Jonathan A.; Valenti, Livio; Kaplan, David L.

doi:10.1021/acsabm.0c00671

Cited by 63 publications

(56 citation statements)

References 41 publications

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“…Published studies have demonstrated that MNs have much potential for delivery of long-acting contraceptives. Yavuz et al [ 329 ] have investigated the silk fibroin-based MN for levonorgestrel sustained release. They found that MN containing levonorgestrel was able to deliver the drug up to 100 days.…”

Section: Current Trend and Prospective Applications Of Microneedlesmentioning

confidence: 99%

Enhancement strategies for transdermal drug delivery systems: current trends and applications

Ramadon

McCrudden

Courtenay

et al. 2021

Drug Deliv. and Transl. Res.

238

159

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Transdermal drug delivery systems have become an intriguing research topic in pharmaceutical technology area and one of the most frequently developed pharmaceutical products in global market. The use of these systems can overcome associated drawbacks of other delivery routes, such as oral and parenteral. The authors will review current trends, and future applications of transdermal technologies, with specific focus on providing a comprehensive understanding of transdermal drug delivery systems and enhancement strategies. This article will initially discuss each transdermal enhancement method used in the development of first-generation transdermal products. These methods include drug/vehicle interactions, vesicles and particles, stratum corneum modification, energy-driven methods and stratum corneum bypassing techniques. Through suitable design and implementation of active stratum corneum bypassing methods, notably microneedle technology, transdermal delivery systems have been shown to deliver both low and high molecular weight drugs. Microneedle technology platforms have proven themselves to be more versatile than other transdermal systems with opportunities for intradermal delivery of drugs/biotherapeutics and therapeutic drug monitoring. These have shown that microneedles have been a prospective strategy for improving transdermal delivery systems. Graphical abstract

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Section: Current Trend and Prospective Applications Of Microneedlesmentioning

confidence: 99%

Enhancement strategies for transdermal drug delivery systems: current trends and applications

Ramadon

McCrudden

Courtenay

et al. 2021

Drug Deliv. and Transl. Res.

238

159

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“…Transdermal administration is a local route of drug delivery that avoids degradation of the drug in the gastrointestinal tract [ 163 ]. For the transdermal administration of the drug, SF-based structures such as microneedles have been used [ 145 , 164 ]. Microneedles are produced by using numerous methods, including micromolding, soft lithography [ 164 ], photolithography, droplet-born air blowing, solvent casting, continuous liquid interface production, and dipping [ 137 ].…”

Section: Silk-based Biomaterials For Drug Delivery In Cancer Treatmentmentioning

confidence: 99%

“…Moreover, similar to other silk-based material formats, they offer mild aqueous processing conditions, biocompatibility, controllable biodegradation, and robust mechanical properties that are sufficient to penetrate the skin for the delivery of pharmaceuticals followed by degradation and excretion from physiological environments [ 15 , 155 ]. The most frequently explored approaches using silk-based composite microneedles are transdermal vaccines [ 165 , 166 ] and contraceptive delivery [ 145 ]. However, in a study by Gao et al, silk fibroin microneedles were capable of transporting the loaded doxorubicin and photothermal compound across the skin without causing pain [ 137 ], which holds future promise for the delivery of a broad range of biomolecules in cancer therapies.…”

Section: Silk-based Biomaterials For Drug Delivery In Cancer Treatmentmentioning

confidence: 99%

“… Silk-based systems used for local and systemic controlled delivery of therapeutic agents. Images are reproduced with permission from the cited articles for scaffolds [ 141 ], film [ 142 ], fiber mats [ 143 ], hydrogels [ 144 ], sponges [ 128 ], microneedles [ 145 ], spheres [ 125 ], particles [ 146 ], capsules [ 147 ], and complexes [ 83 ]. Created with accessed on 31 August 2021.…”

Section: Figurementioning

confidence: 99%

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Systemic and Local Silk-Based Drug Delivery Systems for Cancer Therapy

Florczak

Deptuch

Kucharczyk

et al. 2021

Cancers

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For years, surgery, radiotherapy, and chemotherapy have been the gold standards to treat cancer, although continuing research has sought a more effective approach. While advances can be seen in the development of anticancer drugs, the tools that can improve their delivery remain a challenge. As anticancer drugs can affect the entire body, the control of their distribution is desirable to prevent systemic toxicity. The application of a suitable drug delivery platform may resolve this problem. Among other materials, silks offer many advantageous properties, including biodegradability, biocompatibility, and the possibility of obtaining a variety of morphological structures. These characteristics allow the exploration of silk for biomedical applications and as a platform for drug delivery. We have reviewed silk structures that can be used for local and systemic drug delivery for use in cancer therapy. After a short description of the most studied silks, we discuss the advantages of using silk for drug delivery. The tables summarize the descriptions of silk structures for the local and systemic transport of anticancer drugs. The most popular techniques for silk particle preparation are presented. Further prospects for using silk as a drug carrier are considered. The application of various silk biomaterials can improve cancer treatment by the controllable delivery of chemotherapeutics, immunotherapeutics, photosensitizers, hormones, nucleotherapeutics, targeted therapeutics (e.g., kinase inhibitors), and inorganic nanoparticles, among others.

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“…Microneedles (MNs) are medical devices containing microscopic needle shaped projections that can be applied to the skin to deliver a wide range of therapeutics in a minimally invasive, painless, and safe manner [21][22][23][24] . Biodegradable polymer MNs are able to facilitate controlled release of the therapeutic cargo 25 and therefore could be exploited for the release of hormonal contraceptives over extended periods of time (≥1month) [26][27][28][29] .…”

Section: Introductionmentioning

confidence: 99%

Human-centred design of a new microneedle-based hormonal contraceptive delivery system

Gualeni

Hughes

Stauber³

et al. 2021

Gates Open Res

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Background: It is estimated that 225 million women worldwide have an unmet need for family planning, and more than half live in low- and middle-income countries. Increasing the choice of contraceptive methods available can reduce this unmet need. Microneedle drug delivery systems represent a new technology for minimally invasive self-administration of contraceptives. We explored stakeholders’ views on different aspects of a proposed microneedle-based hormonal contraceptive delivery system. The feedback was used to iteratively develop this delivery system. Methods: Focus group discussions and semi-structured interviews were conducted with potential stakeholders (women and trans males of childbearing age, their partners, and health professionals and organisations that provide family planning advice and contraception services) in Uganda, The Gambia, Malawi, and the UK, exploring concept acceptability and gathering feedback on different aspects of design and usability of the proposed delivery system. Results: Participants viewed the concept of a new, microneedle-based contraceptive favourably. In Uganda, participants were presented with 7 different prototype applicators and identified desirable features of a preferred delivery device; their input reducing the number of prototypes that were subsequently evaluated by stakeholders in The Gambia and the UK. Participants in these countries helped to identify and/or confirm the most desirable characteristics of the applicator, resulting in design consolidation into a refined concept applicator. The final, optimised applicator prototype was validated during user research in Malawi. This human-centred design approach was also used to iteratively develop an information leaflet for the device. During these user studies, other preferred aspects of a contraceptive delivery system were also evaluated, such as anatomical site of application, duration of action, and return to fertility. Conclusions: A new microneedle-based contraceptive delivery system was iteratively developed using a human-centred design approach and was favourably received by potential stakeholders. The product is now being refined for testing in pre-clinical studies.

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Silk Fibroin Microneedle Patches for the Sustained Release of Levonorgestrel

Cited by 63 publications

References 41 publications

Enhancement strategies for transdermal drug delivery systems: current trends and applications

Enhancement strategies for transdermal drug delivery systems: current trends and applications

Systemic and Local Silk-Based Drug Delivery Systems for Cancer Therapy

Human-centred design of a new microneedle-based hormonal contraceptive delivery system

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