Silk fibroin film-coated MgZnCa alloy with enhanced in vitro and in vivo performance prepared using surface activation

Wang, Chenxi; Fang, Hui; Qi, Xiaoyun; Chen, Hang; Sun, Yun; Peng, Zhibin; Wei, Wei; Wang, Yansong

doi:10.1016/j.actbio.2019.04.048

Cited by 52 publications

(31 citation statements)

References 64 publications

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“…SF films loaded with curcumin (Cur), glutaraldehyde (GA), and glycerols (Gly), 7 blended with alginate, 8 and graphene oxide 9 were developed for wound healing and biomedical applications 10 . Antibiotic‐loaded SF films coated with CoCrMo alloy 11 and MgZnCa for orthopedic application 12 and nanopatterned film for post‐surgical complications 13 were reported.…”

Section: Introductionmentioning

confidence: 99%

Antibiotic‐based silk fibroin films for burn wound healing

Yerra

Mamatha

2020

Polymers for Advanced Techs

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Silk fibroin (SF), which is a protein‐based biomacromolecule, proved to be an important biomaterial in biomedical applications and tissue engineering. The present study mainly focused to investigate the effective antibiotic against the common pathogens found at the site of burn wounds. The SF films prepared with selected antibiotics had shown activity against the target bacterial pathogens, but no activity was found against fungal species. The release of antibiotics from films resulted in the microbial susceptibility. Results have shown Ciprofloxacin—6 μg, Amoxicillin—15 μg, and Nystatin—70 μg at minimal inhibition concentration (MIC) has shown maximum zone of inhibition when compared with other antibiotics. The antibiotic‐based silk fibroin (ABSF) films have shown a positive effect on cell viability and cell adhesion on the L929 fibroblast cell line. The structural conformations of films were also carried out by FTIR and XRD, an increase in the crystalline size was observed in the antibiotic‐based film. Results demonstrate that ABSF films can act against the pathogens without losing their drug nature, can reduce the chance of infections at the site of the wound, and also can establish the basis for the accelerated healing process of the burn wound.

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Section: Introductionmentioning

confidence: 99%

Antibiotic‐based silk fibroin films for burn wound healing

Yerra

Mamatha

2020

Polymers for Advanced Techs

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“…Their result indicated that the SF film provided corrosion-resistant protection as a biological barrier, effectively delaying the degradation of the Mg-Zn-Ca alloy substrate. According to Figure 9 [92], the cells on the bare Mg-Zn-Ca samples had a spherical morphology and remained round throughout the incubation period. The cells on the surface of the coated samples containing silk fibroin and SF-Mg-Zn-Ca (VUV/O 3 ) were almost stretched out and displayed enhanced cellular spreading and adhesion abilities.…”

Section: Silk Fibroin Coated On Mg-based Alloymentioning

confidence: 96%

“…Meanwhile, the addition of SA significantly increases the Mg alloy coated corrosion resistance, causing a reaction layer to form in the corrosion procedure. In a similar study, Wang et al [92] used a natural silk fibroin protein coating to enhance the biocompatibility and control corrosion resistance of a Mg-Zn-Ca alloy. Their result indicated that the SF film provided corrosion-resistant protection as a biological barrier, effectively delaying the degradation of the Mg-Zn-Ca alloy substrate.…”

Section: Silk Fibroin Coated On Mg-based Alloymentioning

confidence: 99%

A Comprehensive Review on Surface Modifications of Biodegradable Magnesium-Based Implant Alloy: Polymer Coatings Opportunities and Challenges

et al. 2021

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The development of biodegradable implants is certainly intriguing, and magnesium and its alloys are considered significant among the various biodegradable materials. Nevertheless, the fast degradation, the generation of a significant amount of hydrogen gas, and the escalation in the pH value of the body solution are significant barriers to their use as an implant material. The appropriate approach is able to solve this issue, resulting in a decrease the rate of Mg degradation, which can be accomplished by alloying, surface adjustment, and mechanical treatment. Surface modification is a practical option because it not only improves corrosion resistance but also prepares a treated surface to improve bone regeneration and cell attachment. Metal coatings, ceramic coatings, and permanent polymers were shown to minimize degradation rates, but inflammation and foreign body responses were also suggested. In contrast to permanent materials, the bioabsorbable polymers normally show the desired biocompatibility. In order to improve the performance of drugs, they are generally encapsulated in biodegradable polymers. This study summarized the most recent advancements in manufacturing polymeric coatings on Mg alloys. The related corrosion resistance enhancement strategies and future potentials are discussed. Ultimately, the major challenges and difficulties are presented with aim of the development of polymer-coated Mg-based implant materials.

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“…Zn 2+ is a component of more than 200 enzymes in the human body and plays an important role in the metabolism of proteins, fats, sugars, and nucleic acids; Zn 2+ also exhibits antibacterial and anti-inflammatory functions [15,16]. Ca 2+ maintains the normal muscle expansion and relaxation function of the human body and retains the integrity and permeability of the cell membrane [17]. Mg-Zn alloy has good biocompatibility and high plasticity [18], and the third element of Ca can refine the grain size.…”

Section: Introductionmentioning

confidence: 99%

Effect of melting method on the bio-corrosion resistance of Mg₆₇Zn₂₈Ca₅ cast magnesium alloy in simulated body fluid

Wang

Ding

et al. 2020

Mater. Res. Express

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In recent years, biodegradable magnesium alloys have attracted considerable attention in medical devices, such as permanent implants and stents. However, poor corrosion resistance is a major problem limiting the practical application of magnesium alloys. In this study, Mg 67 Zn 28 Ca 5 alloys were prepared via two different methods, namely, vacuum induction melting and ulfur hexafluoride shielded melting. The effect of melting method on the bio-corrosion resistance of MgZnCa cast magnesium alloy was also studied. The microstructure and phase composition of Mg 67 Zn 28 Ca 5 alloys were investigated by optical microscopy and X-ray diffraction. The element distribution and surface morphology of Mg 67 Zn 28 Ca 5 alloys were examined by scanning electron microscopy and energydispersive spectroscopy. The corrosion resistance of Mg 67 Zn 28 Ca 5 alloys was measured via electrochemical and immersion tests. Results showed uniform composition of the Mg 67 Zn 28 Ca 5 alloy melted by vacuum induction. Immersed in the simulated body fluid, the corrosion rate of Mg 67 Zn 28 Ca 5 by vacuum induction melting (0.2618 mm/a) was lower than that by ulfur hexafluoride shielded melting (0.9686 mm/a); the corrosion potential of Mg 67 Zn 28 Ca 5 melted by vacuum induction (−1313 mV) was nobler than that by ulfur hexafluoride shielded melting (−1483 mV); the corrosion current of Mg 67 Zn 28 Ca 5 by vacuum induction melting (1.202×10 −5 A) was lower than that by ulfur hexafluoride shielded melting (4.332×10 −5 A). The Mg 67 Zn 28 Ca 5 by vacuum induction melting showed uniform corrosion behavior.

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Silk fibroin film-coated MgZnCa alloy with enhanced in vitro and in vivo performance prepared using surface activation

Cited by 52 publications

References 64 publications

Antibiotic‐based silk fibroin films for burn wound healing

Antibiotic‐based silk fibroin films for burn wound healing

A Comprehensive Review on Surface Modifications of Biodegradable Magnesium-Based Implant Alloy: Polymer Coatings Opportunities and Challenges

Effect of melting method on the bio-corrosion resistance of Mg₆₇Zn₂₈Ca₅ cast magnesium alloy in simulated body fluid

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Silk fibroin film-coated MgZnCa alloy with enhanced in vitro and in vivo performance prepared using surface activation

Cited by 52 publications

References 64 publications

Antibiotic‐based silk fibroin films for burn wound healing

Antibiotic‐based silk fibroin films for burn wound healing

A Comprehensive Review on Surface Modifications of Biodegradable Magnesium-Based Implant Alloy: Polymer Coatings Opportunities and Challenges

Effect of melting method on the bio-corrosion resistance of Mg67Zn28Ca5 cast magnesium alloy in simulated body fluid

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Effect of melting method on the bio-corrosion resistance of Mg₆₇Zn₂₈Ca₅ cast magnesium alloy in simulated body fluid