Silk Fibroin Bending Actuators as an Approach Toward Natural Polymer Based Active Materials

Reizabal, Ander; Correia, Daniela M.; Costa, Carlos M.; Pérez‐Álvarez, Leyre; Vilas, José Luis; Lanceros‐Méndez, S.

doi:10.1021/acsami.9b07533

Cited by 36 publications

(39 citation statements)

References 52 publications

(94 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The silk fibroin-based fibers (SFs) can be obtained either from pure silk fibroin or blended with other materials such as synthetic or natural polymers or small molecules. The presence of other components in SFs can influence the silk physical properties or can enrich their functionalities [17][18][19][20]. A suitable candidate that can modify the drug release properties due to its structural and physicochemical properties is casein.…”

Section: Introductionmentioning

confidence: 99%

Diclofenac Embedded in Silk Fibroin Fibers as a Drug Delivery System

Šišková

Kozma²,

Opálek

et al. 2020

Materials

View full text Add to dashboard Cite

Silk fibroin is a biocompatible, non-toxic, mechanically robust protein, and it is commonly used and studied as a material for biomedical applications. Silk fibroin also gained particular interest as a drug carrier vehicle, and numerous silk formats have been investigated for this purpose. Herein, we have prepared electrospun nanofibers from pure silk fibroin and blended silk fibroin/casein, followed by the incorporation of an anti-inflammatory drug, diclofenac. Casein serves as an excipient in pharmaceutical products and has a positive effect on the gradual release of drugs. The characteristics of the investigated composites were estimated by scanning electron microscope, transmission electron microscope, thermogravimetric analysis, and a lifetime of diclofenac by electron paramagnetic resonance analysis. The cumulative release in vitro of diclofenac sodium salt, together with the antiproliferative effect of diclofenac sodium salt-loaded silk nanofibers against the growth of two cancer cell lines, are presented and discussed.

show abstract

Section: Introductionmentioning

confidence: 99%

Diclofenac Embedded in Silk Fibroin Fibers as a Drug Delivery System

Šišková

Kozma²,

Opálek

et al. 2020

Materials

View full text Add to dashboard Cite

show abstract

“…(Figure 10a), indicating that high voltages favored the ions' movement within the polymer matrix [19]. The strain developed as a response to the applied electrical field resulted from the diffusion of the ions and migration to the positive (cations) and negative (anions) electrode layers, leading to the migration of the cations and anions, and subsequent accumulation close to the electrodes [19,37] (Figure 10b).…”

Section: Mechanical Propertiesmentioning

confidence: 99%

Development of Poly(l-Lactic Acid)-Based Bending Actuators

et al. 2020

View full text Add to dashboard Cite

This work reports on the development of bending actuators based on poly(l-lactic acid) (PLLA)/ionic liquid (IL) blends, through the incorporation of 40% wt. of the 1-ethyl-methylimidazolium bis(trifluoromethylsulfonyl)imide ([Emim][TFSI]) IL. The films, obtained by solvent casting at room temperature and 50 °C, were subjected to several post-thermal treatments at 70, 90, 120 and 140 °C, in order to modify the crystallinity of the films. The influence of the drying temperature and of [Emim][TFSI] blending on the morphological, structural, mechanical and electrical properties of the composite materials were studied. The IL induced the formation of a porous surface independently of the processing conditions. Moreover, the [Emim][TFSI] dopant and the post-thermal treatments at 70 °C promoted an increase of the degree of crystallinity of the samples. No significant changes were observed in the degree of crystallinity and Young Modulus for samples with thermal treatment between 70 and 140 °C. The viability of the developed high ionic conductive blends for applications as soft actuators was evaluated. A maximum displacement of 1.7 mm was achieved with the PLLA/[Emim][TFSI] composite prepared at 50 °C and thermally treated at 140 °C, for an applied voltage of 10 Vpp, at a frequency of 100 mHz. This work highlights interesting avenues for the use of PLLA in the field of actuators.

show abstract

“…The assignment of the vibrational bands was performed by deconvolution of the Amide I region, as described in previous works. [19] Thermal analysis was performed with a thermal gravimetric analyzer (TGA) TGA/SDTA 851e Metter Toledo apparatus in the temperature range from 25 to 800 C at a heating rate 10 C min À1 under air flow. DSC measurements were carried out with a Mettler Toledo DSC 822e equipment.…”

Section: Methodsmentioning

confidence: 99%

“…SF and CFO/SF nanocomposites thermal transitions were studied by DSC. Bonded solvent evaporation may mask the SF thermal transitions, [19] and therefore, to remove them, all the samples were heated at 170 C for 5 min before the DSC analysis. The DSC thermograms after this procedure are plotted in Figure 3b.…”

Section: Thermal and Dynamic Mechanical Analysismentioning

confidence: 99%

“…Ionic liquids were also used as additives giving to the SF the ability to respond to external electric fields to form an electric actuator. [19] In this context, magnetic fiber composites based on SF with cobalt ferrite (CoFe 2 O 4 ) or magnetite (Fe 3 O 4 ) nanoparticles were fabricated as scaffolds for tissue-engineering applications by electrospinning, [20] showing that neither SF pristine fibers nor the SF composites are cytotoxic, indicating their suitability for tissue-engineering applications. [20] Furthermore, nanocomposites based on SF and superparamagnetic iron oxide nanoparticles (SPIONs) have been also fabricated by electrospinning as a magnetically responsive cytocompatible scaffold for tissue engineering.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Silk Fibroin Based Magnetic Nanocomposites for Actuator Applications

et al. 2020

Self Cite

View full text Add to dashboard Cite

Recent technological and environmental advances are being redirected to develop technologies based on advanced materials that are not dependent on fossil fuels and/or critical elements. [1] Among them, smart materials showing piezoelectric, [2] piezoresistive, [3] photosensitive, [4] or magnetics properties, [5] among others, are particularly interesting for applications such as electronics, sensors, or actuators. Polymer composites stand out in the development of smart and multifunctional materials as polymer matrixes in which suitable fillers, i,e, metallic, ceramic, or magnetic micro/ nanoparticles, are incorporated, to tailor materials response toward specific applications. [6] Furthermore, those composites are often compatible with additive manufacturing technologies that enlarges their applicability. Different synthetic polymer matrices are being used in the development of polymer composites such as thermoplastics, thermosets or elastomers, but to reduce the processing and consumption of fossil fuels, biopolymers are increasingly being used. [7] Silk fibroin (SF) polymer has been investigated for biomedical, [8] energy storage, [9] and electronic applications [10] due to its excellent intrinsic characteristics. SF is a natural macromolecular protein produced in the specialized glades of Bombyx Mori silkworm. [11] SF is packed in cocoons and acts as shield versus foreign threats, solar radiation, temperature, humidity, parasites, and predators during the

show abstract

Silk Fibroin Bending Actuators as an Approach Toward Natural Polymer Based Active Materials

Cited by 36 publications

References 52 publications

Diclofenac Embedded in Silk Fibroin Fibers as a Drug Delivery System

Diclofenac Embedded in Silk Fibroin Fibers as a Drug Delivery System

Development of Poly(l-Lactic Acid)-Based Bending Actuators

Silk Fibroin Based Magnetic Nanocomposites for Actuator Applications

Contact Info

Product

Resources

About