Silk fibroin based antibacterial bionanotextiles as wound dressing materials

Çalamak, Semih; Erdoğdu, Ceren; Özalp, Meral; Ulubayram, Kezban

doi:10.1016/j.msec.2014.07.001

Cited by 150 publications

(78 citation statements)

References 53 publications

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“…Inorganic particles and polymers have been blended with SF to prepare composites, especially for improvement of antimicrobial properties . Recent antimicrobial materials focus on cationic polymers, metallic nanoparticles, and antimicrobial peptides.…”

Section: Introductionmentioning

confidence: 99%

Chitosan/silk fibroin composite scaffolds for wound dressing

Guang

et al. 2015

J of Applied Polymer Sci

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Three‐dimensional (3D) chitosan/silk fibroin (CS/SF) porous composite scaffolds have been prepared by simply coating a thin layer of CS onto spunlaced SF scaffolds via hydrogen‐bonding assembly technique, and they were characterized by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), X‐ray diffraction (XRD), and mechanical property measurements. The results show that porous scaffolds have a pore diameter around 50–200 μm, and improved mechanical property compared with SF, resulting from strong intermolecular hydrogen bonding interactions between CS and SF, together with the maintained β‐sheet structure of SF. The medical and biological properties of the composite scaffolds were further evaluated. The results demonstrate that they possess good biocompatibility and a broad spectrum of antimicrobial properties. The in vivo animal experiments show that the composite scaffolds promote skin regeneration of rats without any teratogenic effect and inflection, thus they are very promising in the application of wound dressings. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42503.

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Section: Introductionmentioning

confidence: 99%

Chitosan/silk fibroin composite scaffolds for wound dressing

Guang

et al. 2015

J of Applied Polymer Sci

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“…As defined in the literature, an ideal wound dressing should maintain a moist environment and oxygen permeation, should absorb excess exudates and prevent bacterial contaminations, and should be non-adherent to the wound and easily removable [24,25]. The devices developed in this work are intended to provide absorption due to the presence of cotton, and to prevent infections due to the presence of silver.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Assessment of the Antibacterial Potential of Silver Nano-Coatings on Cotton Gauzes for Prevention of Wound Infections

et al. 2016

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Multidrug-resistant organisms are increasingly implicated in acute and chronic wound infections, thus compromising the chance of therapeutic options. The resistance to conventional antibiotics demonstrated by some bacterial strains has encouraged new approaches for the prevention of infections in wounds and burns, among them the use of silver compounds and nanocrystalline silver. Recently, silver wound dressings have become widely accepted in wound healing centers and are commercially available. In this work, novel antibacterial wound dressings have been developed through a silver deposition technology based on the photochemical synthesis of silver nanoparticles. The devices obtained are completely natural and the silver coatings are characterized by an excellent adhesion without the use of any binder. The silver-treated cotton gauzes were characterized through scanning electron microscopy (SEM) and thermo-gravimetric analysis (TGA) in order to verify the distribution and the dimension of the silver particles on the cotton fibers. The effectiveness of the silver-treated gauzes in reducing the bacterial growth and biofilm proliferation has been demonstrated through agar diffusion tests, bacterial enumeration test, biofilm quantification tests, fluorescence and SEM microscopy. Moreover, potential cytotoxicity of the silver coating was evaluated through 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide colorimetric assay (MTT) and the extract method on fibroblasts and keratinocytes. Inductively coupled plasma mass spectrometry (ICP-MS) was performed in order to determine the silver release in different media and to relate the results to the biological characterization. All the results obtained were compared with plain gauzes as a negative control, as well as gauzes treated with a higher silver percentage as a positive control.

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“…Nanofibers exhibit a lot of wonderful features such as large surface area, possibility to surface functionalization, tunable porosity, a wide range of material selection, and superior mechanical performance . These remarkable properties make the nanofibers ideal candidates for a wide range of biomedical applications including tissue‐engineered scaffolds (e.g., skin, cartilage, bone, blood vessel), dressings for wound healing, biomedical devices, biosensors, and drug delivery systems …”

Section: Introductionmentioning

confidence: 99%

Nanofibers for Biomedical and Healthcare Applications

Rasouli

Barhoum

Bechelany

et al. 2018

Macromolecular Bioscience

220

112

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Unique features of nanofibers provide enormous potential in the field of biomedical and healthcare applications. Many studies have proven the extreme potential of nanofibers in front of current challenges in the medical and healthcare field. This review highlights the nanofiber technologies, unique properties, fabrication techniques (i.e., physical, chemical, and biological methods), and emerging applications in biomedical and healthcare fields. It summarizes the recent researches on nanofibers for drug delivery systems and controlled drug release, tissue‐engineered scaffolds, dressings for wound healing, biosensors, biomedical devices, medical implants, skin care, as well as air, water, and blood purification systems. Attention is given to different types of fibers (e.g., mesoporous, hollow, core‐shell nanofibers) fabricated from various materials and their potential biomedical applications.

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Silk fibroin based antibacterial bionanotextiles as wound dressing materials

Cited by 150 publications

References 53 publications

Chitosan/silk fibroin composite scaffolds for wound dressing

Chitosan/silk fibroin composite scaffolds for wound dressing

In Vitro Assessment of the Antibacterial Potential of Silver Nano-Coatings on Cotton Gauzes for Prevention of Wound Infections

Nanofibers for Biomedical and Healthcare Applications

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