Silk: A Promising Biomaterial Opening New Vistas Towards Affordable Healthcare Solutions

Bandyopadhyay, Ashutosh; Chowdhury, Suvro Kanti; Dey, Souradeep; Moses, Joseph Christakiran; Mandal, Biman B.

doi:10.1007/s41745-019-00114-y

Cited by 71 publications

(54 citation statements)

References 376 publications

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“…This immunogenic response has been linked to the presence of sericin (residual or due to the use of non-degummed silk) within the material (Kundu et al, 2013 ). However, no immunogenicity has been found when using materials composed of a single silk protein, either fibroin or sericin (Bandyopadhyay et al, 2019 ). Many studies have shown the biocompatibility of alkali heat degummed silk materials, such as SF electrospun mats, films, gels, and microparticles.…”

Section: Applicationsmentioning

confidence: 99%

Silk Polymers and Nanoparticles: A Powerful Combination for the Design of Versatile Biomaterials

et al. 2020

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Silk fibroin (SF) is a natural protein largely used in the textile industry but also in biomedicine, catalysis, and other materials applications. SF is biocompatible, biodegradable, and possesses high tensile strength. Moreover, it is a versatile compound that can be formed into different materials at the macro, micro- and nano-scales, such as nanofibers, nanoparticles, hydrogels, microspheres, and other formats. Silk can be further integrated into emerging and promising additive manufacturing techniques like bioprinting, stereolithography or digital light processing 3D printing. As such, the development of methodologies for the functionalization of silk materials provide added value. Inorganic nanoparticles (INPs) have interesting and unexpected properties differing from bulk materials. These properties include better catalysis efficiency (better surface/volume ratio and consequently decreased quantify of catalyst), antibacterial activity, fluorescence properties, and UV-radiation protection or superparamagnetic behavior depending on the metal used. Given the promising results and performance of INPs, their use in many different procedures has been growing. Therefore, combining the useful properties of silk fibroin materials with those from INPs is increasingly relevant in many applications. Two main methodologies have been used in the literature to form silk-based bionanocomposites: in situ synthesis of INPs in silk materials, or the addition of preformed INPs to silk materials. This work presents an overview of current silk nanocomposites developed by these two main methodologies. An evaluation of overall INP characteristics and their distribution within the material is presented for each approach. Finally, an outlook is provided about the potential applications of these resultant nanocomposite materials.

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Section: Applicationsmentioning

confidence: 99%

Silk Polymers and Nanoparticles: A Powerful Combination for the Design of Versatile Biomaterials

et al. 2020

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“…Silk can be produced by a multitude of spiders and insects, including wasps, honey bees and silkworms (the most known is Bombyx mori , which is used for natural large-scale production of silk). Its structure and form depend on the insect species [ 37 ]. Generally, silk consists of fibrous proteins containing highly repetitive sequences of amino acids: fibroin and sericin.…”

Section: Principles Of Mss and Msamentioning

confidence: 99%

“…Silkworm silk is highly biocompatible and easily modifiable, therefore, it finds wide application in diverse areas of medicine, such as tissue engineering, drug delivery, and the development of (bio)sensing devices. Some reviews about the uses of silk- based materials in medicine have been recently published [ 37 , 38 , 39 , 40 , 41 ].…”

Section: Principles Of Mss and Msamentioning

confidence: 99%

Multisensor Systems and Arrays for Medical Applications Employing Naturally-Occurring Compounds and Materials

Pauliukaitė

Voitechovič

2020

Sensors

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The significant improvement of quality of life achieved over the last decades has stimulated the development of new approaches in medicine to take into account the personal needs of each patient. Precision medicine, providing healthcare customization, opens new horizons in the diagnosis, treatment and prevention of numerous diseases. As a consequence, there is a growing demand for novel analytical devices and methods capable of addressing the challenges of precision medicine. For example, various types of sensors or their arrays are highly suitable for simultaneous monitoring of multiple analytes in complex biological media in order to obtain more information about the health status of a patient or to follow the treatment process. Besides, the development of sustainable sensors based on natural chemicals allows reducing their environmental impact. This review is concerned with the application of such analytical platforms in various areas of medicine: analysis of body fluids, wearable sensors, drug manufacturing and screening. The importance and role of naturally-occurring compounds in the development of electrochemical multisensor systems and arrays are discussed.

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“…Macromolecules that occur in living organisms (or are produced by living organisms) are called natural polymers [ 7 ]. A number of protein polymers (silk fibroin [ 21 , 22 , 23 , 24 , 25 ], collagen [ 7 , 26 , 27 , 28 , 29 ], elastin [ 29 ], gelatin [ 30 ]) and polysaccharides (chitosan [ 31 , 32 ], chondroitin sulphate [ 29 ], sodium alginate [ 31 ], hyaluronic acid [ 29 , 31 , 32 ]) are used in biomaterial production. Polymers, derived from natural sources, are characterized by properties desired in tissue engineering: biocompatibility, biodegradability, and lack of immune responses after introduction into the human body [ 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

How to Improve Physico-Chemical Properties of Silk Fibroin Materials for Biomedical Applications?—Blending and Cross-Linking of Silk Fibroin—A Review

Grabska-Zielińska

Sionkowska

2021

Materials

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This review supplies a report on fresh advances in the field of silk fibroin (SF) biopolymer and its blends with biopolymers as new biomaterials. The review also includes a subsection about silk fibroin mixtures with synthetic polymers. Silk fibroin is commonly used to receive biomaterials. However, the materials based on pure polymer present low mechanical parameters, and high enzymatic degradation rate. These properties can be problematic for tissue engineering applications. An increased interest in two- and three-component mixtures and chemically cross-linked materials has been observed due to their improved physico-chemical properties. These materials can be attractive and desirable for both academic, and, industrial attention because they expose improvements in properties required in the biomedical field. The structure, forms, methods of preparation, and some physico-chemical properties of silk fibroin are discussed in this review. Detailed examples are also given from scientific reports and practical experiments. The most common biopolymers: collagen (Coll), chitosan (CTS), alginate (AL), and hyaluronic acid (HA) are discussed as components of silk fibroin-based mixtures. Examples of binary and ternary mixtures, composites with the addition of magnetic particles, hydroxyapatite or titanium dioxide are also included and given. Additionally, the advantages and disadvantages of chemical, physical, and enzymatic cross-linking were demonstrated.

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Silk: A Promising Biomaterial Opening New Vistas Towards Affordable Healthcare Solutions

Cited by 71 publications

References 376 publications

Silk Polymers and Nanoparticles: A Powerful Combination for the Design of Versatile Biomaterials

Silk Polymers and Nanoparticles: A Powerful Combination for the Design of Versatile Biomaterials

Multisensor Systems and Arrays for Medical Applications Employing Naturally-Occurring Compounds and Materials

How to Improve Physico-Chemical Properties of Silk Fibroin Materials for Biomedical Applications?—Blending and Cross-Linking of Silk Fibroin—A Review

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