Silicones for Microfluidic Systems

Kowalewska, Anna; Nowacka, Maria

doi:10.1002/9781118938478.ch24

Cited by 2 publications

(1 citation statement)

References 179 publications

(209 reference statements)

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“…Nevertheless, the hydrophobic character was recovered within 24 h when the sample was stored under vacuum. Although this treatment has been suggested for microfluidic devices, ,− to the best of our knowledge our work was the first experimental demonstration of its suitability for the preparation of O/W emulsion in PDMS microsystems.…”

Section: Resultsmentioning

confidence: 97%

Amphiphilic Polysaccharides Acting both as Stabilizers and Surface Modifiers during Emulsification in Microfluidic Flow-Focusing Junction

Chebil

Fünfschilling

Léonard

et al. 2018

ACS Appl. Bio Mater.

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A continuous emulsion/solvent diffusion process was designed for the preparation of polysaccharide-covered poly(D,L-lactide) (PLA) microparticles. The emulsification step was carried out in a flow-focusing junction where ethyl acetate containing dissolved PLA was dispersed into an aqueous solution of hydrophobically modified dextran. It was demonstrated that poly(dimethylsiloxane) devices could be used for oil-in-water emulsion preparation provided that the microfluidic devices were preconditioned by simply circulating the aqueous phase containing the amphiphilic polysaccharide during a sufficient time (30 h). The adsorption of the polymers at the surface of the channel walls permitted the wetting by the aqueous phase with a hydrophilic character maintained at least throughout 2 months. The preconditioning time was significantly reduced by pretreating the microfluidic device with piranha solution and KOH solution during 15 min each before the circulation of the aqueous solution of dextran derivative. Dextran-covered PLA microparticle aqueous suspensions were produced with well-controlled size distribution. The suspensions could be lyophilized and reconstituted by retrieving the initial size distribution without adding any cryoprotectant. The reported procedure was used for preparing octyl gallate-loaded PLA microparticles.

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