Silicone Implants and the Inhibition of Cancer

Su, Cynthia W.; Dreyfuss, David A.; Krizek, Thomas J.; Leoni, Karen J.

doi:10.1097/00006534-199509000-00001

Cited by 56 publications

(18 citation statements)

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“…These studies support our findings which demonstrate that survival is not negatively impacted by reconstruction. Some have hypothesized that reconstruction itself provides a survival advantage to patients through a biological mechanism (17–20). We suggest other more likely possibilities.…”

Section: Discussionmentioning

confidence: 99%

A Population-Based Study of Breast Cancer-Specific Survival Following Mastectomy and Immediate or Early-Delayed Breast Reconstruction

Agarwal

Pappas

et al. 2012

The Breast Journal

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Immediate breast reconstruction allows for improved patient psychosocial outcomes after mastectomy. We used the Surveillance, Epidemiology, and End Results (SEER) database to study the breast cancer-specific survival of patients treated with immediate or early-delayed breast reconstruction after mastectomy. Population-level de-identified data was abstracted from the SEER database. All female patients treated with mastectomy for a diagnosis of ductal and/or lobular breast cancer between 1998 and 2002 were included. Breast cancer-specific survival was reported as hazard ratios using multivariate analysis to control for patient demographic and oncologic covariates. Demographic covariates included age, race, marital status, income, education, and county metropolitan status; oncologic covariates included tumor stage, histology, grade, lymph node status, hormone receptor status, receipt of radiation therapy, and unilateral or bilateral mastectomy. A total of 52,249 patients were included in the study. Patients treated with mastectomy and reconstruction had a significantly lower hazard of death (HR 0.73, p < 0.0001) compared with patients treated with mastectomy only. Black patients had a significantly increased hazard of death (HR 1.42, p < 0.0001) compared with white patients. Receipt of radiotherapy did not significantly associate with hazard of death (HR 1.03, p = 0.3494). Additionally, bilateral mastectomy did not significantly associate with hazard of death (HR 0.98, p = 0.763). Our analysis shows that patients who undergo breast reconstruction after mastectomy have a higher breast cancer-specific survival than those undergoing mastectomy alone, when controlling for demographic and oncologic covariates. Further research is required to understand the nature of this relationship.

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Section: Discussionmentioning

confidence: 99%

A Population-Based Study of Breast Cancer-Specific Survival Following Mastectomy and Immediate or Early-Delayed Breast Reconstruction

Agarwal

Pappas

et al. 2012

The Breast Journal

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“…Breast implants may stimulate a local immune response in which cancer cells are more likely to be destroyed [34]. Breast implants may compress breast tissue, reducing the flow of blood and thereby slowing the rate of cell or tumor growth.…”

Section: Discussionmentioning

confidence: 99%

Untitled

O’Malley

Glaser

et al. 2005

Breast Cancer Res

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“…1 Multiple investigations have to date been alert for the potential adverse health effects of silicone breast implants. [2][3][4][5][6][7][8][9][10][11][12] Additional reports have focused on postoperative local complications and patient safety issues in women receiving silicone breast implants. [13][14][15][16][17][18][19][20] Capsular contracture is the most common and severe complication associated with silicone breast implants, [13][14][15][16][17][18][19][20] despite innovations in shell surface textures, implant shapes, inner gel composition, surgical implantation techniques, and pocket irrigation.…”

mentioning

confidence: 99%