Silicone hydrogel versus hydrogel soft contact lenses for differences in patient-reported eye comfort and safety

Haworth, Kristina M.; Travis, Darian; Abariga, Samuel A; Fuller, Daniel G.; Pucker, Andrew D.

doi:10.1002/14651858.cd014791

Cited by 3 publications

(2 citation statements)

References 55 publications

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“…Made from a polydimethylsiloxane, silicone hydrogels also contain silicone, which tends to attract water less than hydrogel materials, making them more hydrophobic. As a result, the structure of the polymer network in silicone hydrogel materials is more compact and less porous [ 31 , 34 ], which limits the biofouling, the attachment of the bacteria cells to the surface, and bacterial biofilm formation. The obtained results suggest that the higher porosity, water content, and hydrophilicity of hydrogels may promote attachment and colonization of the surface of the contact lens materials by cells containing long pili, such as P. aeruginosa .…”

Section: Resultsmentioning

confidence: 99%

Quantifying the Dynamics of Bacterial Biofilm Formation on the Surface of Soft Contact Lens Materials Using Digital Holographic Tomography to Advance Biofilm Research

Buzalewicz,

Kaczorowska,

Fijałkowski

et al. 2024

IJMS

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The increase in bacterial resistance to antibiotics in recent years demands innovative strategies for the detection and combating of biofilms, which are notoriously resilient. Biofilms, particularly those on contact lenses, can lead to biofilm-related infections (e.g., conjunctivitis and keratitis), posing a significant risk to patients. Non-destructive and non-contact sensing techniques are essential in addressing this threat. Digital holographic tomography emerges as a promising solution. This allows for the 3D reconstruction of the refractive index distribution in biological samples, enabling label-free visualization and the quantitative analysis of biofilms. This tool provides insight into the dynamics of biofilm formation and maturation on the surface of transparent materials. Applying digital holographic tomography for biofilm examination has the potential to advance our ability to combat the antibiotic bacterial resistance crisis. A recent study focused on characterizing biofilm formation and maturation on six soft contact lens materials (three silicone hydrogels, three hydrogels), with a particular emphasis on Staphylococcus epidermis and Pseudomonas aeruginosa, both common culprits in ocular infections. The results revealed species- and time-dependent variations in the refractive indexes and volumes of biofilms, shedding light on cell dynamics, cell death, and contact lens material-related factors. The use of digital holographic tomography enables the quantitative analysis of biofilm dynamics, providing us with a better understanding and characterization of bacterial biofilms.

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Section: Resultsmentioning

confidence: 99%

Quantifying the Dynamics of Bacterial Biofilm Formation on the Surface of Soft Contact Lens Materials Using Digital Holographic Tomography to Advance Biofilm Research

Buzalewicz,

Kaczorowska,

Fijałkowski

et al. 2024

IJMS

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“…In many areas of the human body, hydrogels are encountered, such as in extracellular matrices or as tendons, which are composed of natural macromolecules like collagen or gelatin . In recent years, the use of synthetic hydrogels gained more interest, and they are used nowadays in various applications, such as wound dressings, contact lenses, or for drug delivery systems, as well as tissue engineering and adhesion prophylaxis . According to the classical definition, a hydrogel is a three-dimensional network capable of storing a large amount of water without going into solution itself .…”

Section: Introductionmentioning

confidence: 99%

Development and Characterization of Biodegradable Polyurethane-Urea-Based Hydrogels for the Prevention of Postoperative Peritoneal Adhesions

Kortenbrede,

Heider,

Heckroth

et al. 2024

ACS Omega

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Postoperative peritoneal adhesions occur after more than 60% of abdominal surgeries and can cause severe long-term side effects, such as chronic pain, infertility, and intestinal obstructions. However, currently available products for adhesion prophylaxis often lack efficiency or are too heavy to handle. Hydrogels are promising materials to be used for adhesion prevention as they show good mechanical stability and biocompatibility. Herein, we present a novel two-component sprayable, biodegradable, fast-curing, and shape-adaptive polyurethane urea (PUU) hydrogel system and the establishment of a full characterization approach to investigate its suitability for adhesion prophylaxis according to predefined chemical, mechanical, and biological criteria. We demonstrate that this PUU hydrogel system exhibits a fast-curing behavior, is resilient toward mechanical forces, is biocompatible, and reveals a degradation behavior within a desired time frame to reliably avoid the formation of adhesions. In addition, the PUU hydrogel system functions as an effective barrier for invading cells in vitro. Overall, we propose a guideline for the development and in vitro characterization of synthetic hydrogels for application in minimally invasive adhesion prophylaxis.

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