Silicone gel: a new treatment for burn scars and contractures

Perkins, Kelly; Davey, R. B.; Wallis, K.

doi:10.1016/0305-4179(83)90039-6

Cited by 243 publications

(127 citation statements)

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“…[11][12][13][14] Silicone gel was first used underneath pressure garments to achieve a better fit and was fortuitously noted to have a beneficial effect on hypertrophic burn scars. 15 Quinn et al 16 confirmed the beneficial effects in a larger uncontrolled study. Our group first established these benefits in a prospective randomized controlled trial in which the patient served as his or her own control in burn scars, 8 and then in the prevention and treatment of hypertrophic scars resulting from surgical incisions.…”

supporting

confidence: 64%

Silicone occlusive treatment of hypertrophic scar in the rabbit model

Saulis

Chao

Telser

et al. 2002

Aesthetic Surgery Journal

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supporting

confidence: 64%

Silicone occlusive treatment of hypertrophic scar in the rabbit model

Saulis

Chao

Telser

et al. 2002

Aesthetic Surgery Journal

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“…1 New formulations and formats of silicone gel products are becoming available for use in the treatment of scarring resulting from surgery, burns, and other skin injuries requiring hospital treatment.…”

Section: Translational Relevancementioning

confidence: 99%

The Use of Silicone Adhesives for Scar Reduction

Bleasdale¹,

Finnegan

Murray

et al. 2015

Advances in Wound Care

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Significance: This article discusses the history and developments of silicone gel sheeting (SGS) scar therapy. Furthermore, we review a breadth of literature to gain an insight into how and why topical silicone gels remain the favored treatment of medical experts in scar management. We also analyze an ever increasing number of alternative therapies claiming to provide enhanced scar reduction performance. Recent Advances: Topical silicone gel treatments seem to remain the first point of clinical recommendation in scar management. SGS has been used in scar therapy for over 30 years, during which its efficacy has been the subject of numerous clinical evaluations. Critical Issues: While the exact mechanisms by which SGS improves hypertrophic scars, keloid development and recovery are yet to be fully agreed upon, its ability to do so remains largely undisputed at present. However, there still is ongoing deliberation over the exact mechanism of action of silicone in improving a scar. At present it is likely that through occlusion of the scar site and hydration of the wound bed, the overactivity of scar-related cells is suppressed, and their activity normalized. Future Direction: The clinical support of topical silicone gel products, relative to all alternative scar therapies, is considered the internationally recommended first-line form of scar management, and favored by consensus among healthcare professionals. However, there still remains the need for further clinical evidence and a better understanding of the mechanism behind the benefit of silicone gel for use in the prevention of abnormal scarring. SCOPE AND SIGNIFICANCESilicone gel sheeting (SGS) has been used in scar therapy for over 30 years, during which its efficacy has been the subject of numerous clinical evaluations. While the exact mechanisms by which SGS improves hypertrophic scars, keloid development and recovery are yet to be fully agreed upon, its ability to do so remains largely undisputed. As such, topical silicone gel treatments seem to remain the first point of clinical recommendation in scar management. This article aims to review a breadth of literature to gain an insight not only into how, but also why topical silicone gels remain the favored treatment of medical experts in scar management. We also analyze an ever increasing number of alternative therapies claiming to provide enhanced scar reduction performance as a comparison. TRANSLATIONAL RELEVANCESilicone has been used for more than 30 years in the treatment of cutaneous scars.1 New formulations and formats of silicone gel products are becoming available for use in the treatment of scarring resulting from surgery, burns, and other skin injuries requiring hospital treatment.

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“…Conocemos los efectos adversos que las radiaciones ultravioleta generan en la apariencia de las cicatrices humanas (11). Sin embargo el gel de silicona aplicado de forma tópica parece aportar una oclusión que disminuye el depósito de colágeno en la cicatriz (12), lo que en la clínica se presenta como un tratamiento de primera elección frente a la cicatrización patológi-ca (1,13,14).…”

Section: Discussionunclassified

Evaluación colorimétrica digital de cicatrices patológicas: Estudio comparativo entre gel de silicona y fotoprotector

García

Pascual

Gil-López

et al. 2010

Cir. plást. iberolatinoam.

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Palabras clave Cicatrización, Colorimetría, Gel de silicona, Fotoprotector. Código numérico 1531-1420Presentamos un método reproducible y sencillo para valorar la calidad de las cicatrices desde un punto de vista estéti-co. El empleo de fotografías digitales procesadas mediante programas informáticos, permite realizar mediciones colorimétricas en la cicatriz y en la piel sana adyacente. Los resultados pueden expresarse con fórmulas matemáticas capaces de cuantificar las diferencias cromáticas entre ambas superficies. Hemos comparado con este sistema los resultados obtenidos en 20 pacientes con cicatrices patológicas divididos en 2 series terapéuticas durante 9 meses. Diez pacientes recibieron tratamiento con gel de silicona frente a otros 10 que recibieron tratamiento fotoprotector.El análisis colorimétrico en el estudio independiente reveló que las diferencias estadísticamente significativas halladas entre la cicatriz y la piel sana circundante antes del tratamiento se mantenían en el grupo tratado con fotoprotector, mientras que no aparecían tras el tratamiento con gel de silicona.El estudio colorimétrico relativizado Scar-score (Puntuación de cicatriz), mostró una significativa recesión en ambos grupos, pero que era de mayor entidad en la serie tratada con gel de silicona. Tanto el análisis bivariante como el multivariante revelaron un beneficio terapéutico significativamente mayor en el grupo tratado con gel de silicona frente al grupo con tratamiento fotoprotector. The authors present a reproducible and simple method to evaluate scars from a cosmetic point of view. The use of digital photographs processed by means of computer programs enables us to carry out colorimetric measurements on the scar and adjacent healthy skin. Results can be expressed with mathematical formulae that make it possible to quantify the chromatic differences between both surfaces. The results obtained in 20 patients with pathological scars divided into 2 therapeutic series for 9 months were compared with this system. Ten patients received treatment with silicone gel and another 10 received photoprotector treatment. Colorimetry revealed in the independent study that statistically significant differences found between healthy and scar skin before treatment were maintained in the group treated with the photoprotector gel while they did not appear after administration of the silicone gel. The relativised colorimetric study (Scar-score) showed a significant recession in both groups but this was greater in the group treated with silicone gel. Both the bivariant and multivariant analysis revealed a significantly higher therapeutic benefit in the group treated with silicone gel compared to the photoprotector treatment.Fernández García, A.

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Silicone gel: a new treatment for burn scars and contractures

Cited by 243 publications

References 0 publications

Silicone occlusive treatment of hypertrophic scar in the rabbit model

Silicone occlusive treatment of hypertrophic scar in the rabbit model

The Use of Silicone Adhesives for Scar Reduction

Evaluación colorimétrica digital de cicatrices patológicas: Estudio comparativo entre gel de silicona y fotoprotector

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