Silicone and rheumatic diseases

The Association of Augmentation Mammoplasty with Connective Tissue Disease, Including Systematic Sclerosis (Scleroderma): A Meta-Analysis

“…The possible relationship between augmentation mammoplasty and definite connective tissue disease, particularly systemic sclerosis (scleroderma), has been the subject of many case reports and case series; these have been reviewed elsewhere in several review articles and editorials [1][2][3][4][5][6][7][8][9]. Several epidemiologic studies have been conducted to formally address the hypothesis that women who have undergone augmentation mammoplasty are at greater risk of developing connective tissue disease, particularly systemic sclerosis (scleroderma), than women who have not had this procedure performed [10][11][12][13][14][15][16][17][18][19][20][21].…”

Still's-like disease, breast prosthesis, and collagen implants

“…The ®rst case was mentioned by Endo as he assessed the association of silicone with rheumatic diseases [8]. In the second case, published by Katayama, progressive recovery followed removal of the prosthesis [9], whereas in the third case symptoms resolved after 2 months on aspirin, although the prostheses had been retained [10].…”

Localized scleroderma of the breast after silicone gel implant

“…Byron [13] in 1984 reported a patient who had a morphea on the left breast with a dry syndrome and a positive Waller Rose test. In 1987, Endo [8] reported morpheas 11 years after a silicone implant associated with rheumatoid disease and antinuclear antibodies. Lazar in 1991 [14] described a morphea which appeared two months after an implant on the left breast around the prosthesis with no biological signs.…”