Silicon thin film transistor-based aptamer sensor for COVID-19 detection

Abstract

Since the beginning of the coronavirus disease 2019 (COVID-19) in December 2019 and the current lack to date of specific drugs or vaccinations to cope with the disease, it has become apparent that the surest way of dealing with this is through early diagnosis and management. Current testing has shown to be unable to rapidly and accurately provide the results required to restrict the spread. Here we report the use of an intrinsic silicon thin film transistor functionalised with aptamers designed to attach to the spike protein of COVID-19. It is shown that a linear response can be obtained in a concentration of 10 fM and 10 pM, and that the relative response is independent of the applied potential allowing a sensory system to fine tune the applied potential to facilitate the interpretation of the results.

Label-free electrochemical aptasensor for the detection of SARS-CoV-2 spike protein based on carbon cloth sputtered gold nanoparticles

“… Abrego-Martinez et al, 2022 ; Amouzadeh Tabrizi et al, 2021 ; Curti et al, 2022 ; Farrow et al, 2020 ; Jiang et al, 2021 ; Kurnia Sari et al, 2022 ; Lasserre et al, 2022 ; Singh et al, 2021 ; Tian et al, 2021 ; Zakashansky et al, 2021 .…”

Aptamer-based biosensors and their implications in COVID-19 diagnosis

“…Subsequently, they employed a source-drain voltage sweep (AE15 V) for detection, and represented the detection signal as the current vs. voltage (IV) characteristics of the system. 118 A photoelectrochemical (PEC), RBD-specic aptasensor was fabricated based on the photosensitive electrochemical properties of certain materials, such as graphitic carbon nitride (gC 3 N 4 ) and cadmium sulphide quantum dots (CdS QDs). Such an aptasensor based on PEC analysis for SARS-CoV-2 detection was rst reported by Tabrizi et al A gC 3 N 4 -CdS QD nanocomposite was functionalized with chitosan (CS).…”

“…Subsequently, they employed a source-drain voltage sweep (±15 V) for detection, and represented the detection signal as the current vs. voltage (IV) characteristics of the system. 118…”