Silicon-stabilized α-tricalcium phosphate and its use in a calcium phosphate cement: Characterization and cell response

Mestres, Gemma; Van, Clemence Le; Ginebra, Maria‐Pau

doi:10.1016/j.actbio.2011.11.021

Cited by 99 publications

(61 citation statements)

References 52 publications

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“…The lower mechanical properties in the current study were ascribed to the higher liquid-to-powder ratio employed (0.6 mL.g -1 ) which was needed in order to promote the ideal moldability of the CPC paste. Moreover, in contradiction with previous works [26,28], silicon did not reduce the final mechanical strength of the material but rather significantly increase it (p<0.05).…”

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confidence: 99%

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Influence of Si substitution on the reactivity of α-tricalcium phosphate

Motisuke

Mestres

Renó

et al. 2017

Materials Science and Engineering: C

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Silicon substituted calcium phosphates have been widely studied over the last ten years due to their enhanced osteogenic properties. Notwithstanding, the role of silicon on α-TCP reactivity is not clear yet. Therefore, the aim of this work was to evaluate the reactivity and the properties of Si-α-TCP in comparison to α-TCP. Precursor powders have similar properties regarding purity, particle size distribution and specific surface area, which allowed a better comparison of the Si effects on their reactivity and cements properties. Both Si-α-TCP and α-TCP hydrolyzed to a calcium-deficient hydroxyapatite when mixed with water but their conversion rates were different. Si-α-TCP exhibited a slower setting rate than α-TCP, i.e. k SSA for Si-TCP (0.021 g.m -2 .h -1 ) was almost four times lower than for α-TCP (0.072 g.m -2 .h -1 ). On the other hand, the compressive strength of the CPC resulting from fully reacted Si-α-TCP was significantly higher (12.80± 0.38 MPa) than that of α-TCP (11.44 ± 0.54 MPa), due to the smaller size of the entangled precipitated apatite crystals.

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confidence: 99%

“…were low compared to the values reported on the literature, 20 MPa for Si-TCP [26,28] and 40 MPa for α-TCP [43]. The lower mechanical properties in the current study were ascribed to the higher liquid-to-powder ratio employed (0.6 mL.g -1 ) which was needed in order to promote the ideal moldability of the CPC paste.…”

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confidence: 72%

Influence of Si substitution on the reactivity of α-tricalcium phosphate

Motisuke

Mestres

Renó

et al. 2017

Materials Science and Engineering: C

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“…The formed bone‐like apatite layers grew keeping their shapes after 14 and 21 of days soaking as illustrated in Figs. b and c. The morphology of the bone‐like apatite layers is very similar to those of apatite particles on the surface of bioactive glasses and glass–ceramics . To evaluate the ability to form apatite on diopside ceramics by the MS, samples of diopside sintered at 1125°C for 15 min were selected.…”

Section: Resultsmentioning

confidence: 99%

A New and Economic Approach to Synthesize and Fabricate Bioactive Diopside Ceramics Using a Modified Domestic Microwave Oven. Part 1: Study of Sintering and Bioactivity

Harabi

Zouai

2013

Int J Applied Ceramic Tech

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Diopside (CaMgSi2O6) ceramics was synthesized and fabricated by a simple solid‐state reaction rather than other used processes. This new and economic approach for diopside fabrication consists mainly of replacing the usually used starting materials by other more economic (activated CaO·MgO powders), using conventional sintering and microwave sintering. The P2O5 addition (0.5–5.0 wt%) promotes sintering, crystallization, and bioactivity. Additionally, a considerably low weight loss ratio (0.21%) was also obtained for these samples, after 2 days of soaking in lactic acid. Carbonated hydroxyapatite (CHA) formation in simulated body fluid was confirmed for all sintered samples. Both sintering and CHA formation mechanisms were proposed.

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“…No change in the microstructure was observed by SEM after drying. While it is true that the drying step has been shown to have an impact on pore structure in some cementitious materials that contain a gel-like phase, like Portland cement [44], the situation is expected to be rather different in the CPCs analysed in this work, where the drying step at 100ºC is expected to cause only the loss of the surface-bound water in the calcium deficient hydroxyapatite obtained as the reaction product [46,47].…”

Section: Porosity At the Nanoscale: Characterization By Nitrogen Sorpmentioning

confidence: 99%

Multiple characterization study on porosity and pore structure of calcium phosphate cements

2015

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Being able to thoroughly characterize the intricate pore structure of calcium phosphate cements is a key step to successfully link the structural properties of these synthetic bone grafts with their most relevant properties, such as in vitro or in vivo behaviour, drug loading and release properties or degradation over time. This is a challenging task, due to the wide range of pore sizes compared to most other ceramic biomaterials. This work provides a critical assessment of three different techniques based on different physical phenomena, namely Mercury Intrusion Porosimetry (MIP), Nitrogen sorption and Thermoporometry (TPM) for the detailed characterization of four calcium phosphate cements with different textural properties, in terms of total porosity, Pore Size Distribution (PSD) and Pore Entrance Size Distribution (PESD). MIP had the advantage of covering a much wider size range than TPM and Nitrogen sorption, offering a more comprehensive information at the micrometric level. TPM, and specially Nitrogen sorption, besides being non-destructive techniques, and although covering a limited size range, provided complementary information regarding pore structure associated to crystal shape at the nanoscale, recording both PSD and PESD in a single experiment. MIP tended to register smaller sizes, especially at low L/P ratios, due to the network effect, that has a strong influence on the outcome of this technique.¡

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Silicon-stabilized α-tricalcium phosphate and its use in a calcium phosphate cement: Characterization and cell response

Cited by 99 publications

References 52 publications

Influence of Si substitution on the reactivity of α-tricalcium phosphate

Influence of Si substitution on the reactivity of α-tricalcium phosphate

A New and Economic Approach to Synthesize and Fabricate Bioactive Diopside Ceramics Using a Modified Domestic Microwave Oven. Part 1: Study of Sintering and Bioactivity

Multiple characterization study on porosity and pore structure of calcium phosphate cements

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