Silicon/Silver nanocomposite-based surface-enhanced Raman spectroscopy (SERS) biosensor for ultrasensitive direct detection of deafness mutations in real system
Arwa Al Safadi,
Krithikadevi Ramachandran,
Abdelaziz Tlili
et al.
Abstract:Surface-enhanced Raman scattering (SERS) is a promising emerging, highly sensitive technique for detecting biological samples. The current research aims to bring an effortless biosensor-based approach to detect and discriminate DNA mutations with their fingerprints for each deafness mutation within the GJB2 (gap junction beta 2) gene. Therefore, we developed silver (Ag) modified silicon-based SERS sensing platform to directly screen GJB2 gene mutations for UAE patients with hereditary hearing loss (HL). The pr… Show more
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