Silicon-photonic interferometric biosensor using active phase demodulation

Marin, Yisbel E.; Toccafondo, V.; Velha, Philippe; Scarano, Simona; Tirelli, Stefano; Nottola, A.; Jeong, Young-Sun; Jeon, Hyunpyo; Minunni, Maria; Pasquale, F. Di; Otón, Claudio J.

doi:10.1117/12.2287803

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…Interferometric Mach-Zehnder sensors, conversely, only require a fixed wavelength source and direct power detection at the output. While basic Mach-Zehnder configurations suffer from sensitivity fading and phase ambiguity [25], different techniques have been proposed to overcome this limitation, e.g., wavelength [26] and thermal [27] modulation. Coherently detected interferometers provide completely linear phase read-out [28,29], offering state-of-the-art bulk LOD [22] and calibration techniques than can cancel hardware imperfections [30].…”

Section: Introductionmentioning

confidence: 99%

“…Coherently detected interferometers provide completely linear phase read-out [28,29], offering state-of-the-art bulk LOD [22] and calibration techniques than can cancel hardware imperfections [30]. Most recent MZI-based sensors report LODs of the order of 10−70.166667emRIU [4,11,18,21,22,26,27,31,32]. An exceptionally low LOD of 2.7×10−80.166667emRIU was reported in [22], albeit using an imbalanced silicon MZI with a 90.166667emmm length difference, which exhibits a stronger sensitivity to laser phase jitter than a balanced interferometer.…”

Section: Introductionmentioning

confidence: 99%

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Optimizing the Limit of Detection of Waveguide-Based Interferometric Biosensor Devices

Leuermann

Gavela

Torres-Cubillo

et al. 2019

Sensors

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Waveguide-based photonic sensors provide a unique combination of high sensitivity, compact size and label-free, multiplexed operation. Interferometric configurations furthermore enable a simple, fixed-wavelength read-out making them particularly suitable for low-cost diagnostic and monitoring devices. Their limit of detection, i.e., the lowest analyte concentration that can be reliably observed, mainly depends on the sensors response to small refractive index changes, and the noise in the read-out system. While enhancements in the sensors response have been extensively studied, noise optimization has received much less attention. Here we show that order-of-magnitude enhancements in the limit of detection can be achieved through systematic noise reduction, and demonstrate a limit of detection of ∼ 10 - 8 RIU with a silicon nitride sensor operating at telecom wavelengths.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Optimizing the Limit of Detection of Waveguide-Based Interferometric Biosensor Devices

Leuermann

Gavela

Torres-Cubillo

et al. 2019

Sensors

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“…This method allows univocal determination of the phase variations without sensitivity fading, requiring only a fixed laser and a photodetector, which could potentially be integrated on chip [2], resulting in a low-cost, robust interrogation system for point-of-care applications. This paper is a more in-depth work with respect to the recent conference publication [14].…”

mentioning

confidence: 99%

Silicon Photonic Biochemical Sensor on Chip Based on Interferometry and Phase-Generated-Carrier Demodulation

Marin

Toccafondo

Velha

et al. 2019

IEEE J. Select. Topics Quantum Electron.

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Integrated biochemical sensors based on Mach-Zehnder interferometers (MZIs) rely on the evanescent field detection principle to monitor the phase shift induced by a refractive index change on the surface of the sensing arm, providing a high sensitivity thanks to the long interaction length with the analyte. This paper presents an integrated refractive index and biochemical sensor based on a pair of balanced MZIs realized on silicon-on-insulator. The device includes a thermal phase modulator in one of the branches of each MZI to extract univocally the induced phase change by applying active phase detection based on the phase generated carrier technique. The direct modulation of the MZI results in a simple configuration of the sensor, only requiring a fixed wavelength laser and a photodetector, enabling the possibility of full monolithic integration. The results of refractive index measurements show a detection limit down to 4.88 × 10-7 RIU. Additionally, an immunoassay reports the binding of anti-bovine serum albumin (BSA) to BSA, with anti-BSA concentrations down to 33.33 nM. Index Terms-Optical sensors, chemical and biological sensors, photonic integrated circuits, interferometry, phase modulation. I. INTRODUCTION I N THE past decades, there has been a growing interest in integrated photonic biochemical sensors for a wide range of applications, such as clinical diagnosis, food safety and chemical and biological warfare surveillance [1]. In particular, silicon

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A label-free biosensor based on E-SMS optical fiber structure for anti BSA detection

Patiño-Jurado

Cardona-Maya

Jaramillo-Grajales

et al. 2022

Optical Fiber Technology

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Silicon-photonic interferometric biosensor using active phase demodulation

Cited by 4 publications

References 9 publications

Optimizing the Limit of Detection of Waveguide-Based Interferometric Biosensor Devices

Optimizing the Limit of Detection of Waveguide-Based Interferometric Biosensor Devices

Silicon Photonic Biochemical Sensor on Chip Based on Interferometry and Phase-Generated-Carrier Demodulation

A label-free biosensor based on E-SMS optical fiber structure for anti BSA detection

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