Silicon photonic acoustic detector (SPADE) using a silicon nitride microring resonator

Nagli, Michael; Moisseev, Ron; Suleymanov, Nathan; Kaminski, Eitan; Hazan, Yoav; Gelbert, Gil; Goykhman, Ilya; Rosenthal, Amir

doi:10.1016/j.pacs.2023.100527

Cited by 2 publications

(5 citation statements)

References 46 publications

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“…The fabrication process and sensing performance of SPADE are thoroughly described in Ref. 24. Briefly, the detector relies on a micro-ring resonator (MRR) implemented in a silicon nitride (SiN) platform, where ultrasound detection occurs through the evanescent field of the guided optical mode.…”

Section: Spadementioning

confidence: 99%

“…In this paper, we demonstrate an OR-OAM configuration that utilizes the previously demonstrated silicon-photonics acoustic detector (SPADE) 23,24 with semi-isotropic sensitivity, enabling a non-coaxial setup. Specifically, as SPADE detects signals from all directions, it enables the focusing of the optoacoustic beam to the side of the detector rather than through it, facilitating epi-illumination with opaque detector materials.…”

mentioning

confidence: 99%

“…In this work, the SPADE sensing element is a 30 μm micro-ring resonator fabricated in silicon nitride, which has achieved a bandwidth of 120 MHz and a noise-equivalent pressure of 7 mPa∕Hz 1∕2 . 24 The high sensitivity of SPADE is crucial for enabling a non-coaxial configuration due to the high attenuation of the acoustic waves away from the focal spot. Our OR-OAM system is demonstrated in both epi-and trans-illumination configurations, and its performance is assessed in phantoms and in vivo.…”

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confidence: 99%

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Large-field-of-view optical-resolution optoacoustic microscopy using a stationary silicon-photonics acoustic detector

Harary,

Nagli,

Suleymanov

et al. 2024

J. Biomed. Opt.

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Optical-resolution optoacoustic microscopy (OR-OAM) enables labelfree imaging of the microvasculature by using optical pulse excitation and acoustic detection, commonly performed by a focused optical beam and an ultrasound transducer. One of the main challenges of OR-OAM is the need to combine the excitation and detection in a coaxial configuration, often leading to a bulky setup that requires physically scanning the ultrasound transducer to achieve a large field of view.Aim: The aim of this work is to develop an OR-OAM configuration that does not require physically scanning the ultrasound transducer or the acoustic beam path.Approach: Our OR-OAM system is based on a non-coaxial configuration in which the detection is performed by a silicon-photonics acoustic detector (SPADE) with a semi-isotropic sensitivity. The system is demonstrated in both epi-and transillumination configurations, where in both configurations SPADE remains stationary during the imaging procedure and only the optical excitation beam is scanned. Results:The system is showcased for imaging resolution targets and for the in vivo visualization of the microvasculature in a mouse ear. Optoacoustic imaging with focal spots down to 1.3 μm, lateral resolution of 4 μm, and a field of view higher than 4 mm in both lateral dimensions were demonstrated. Conclusions:We showcase a new OR-OAM design, compatible with epi-illumination configuration. This setup enables relatively large fields of view without scanning the acoustic detector or acoustic beam path. Furthermore, it offers the potential for high-speed imaging within compact, miniature probe and could potentially facilitate the clinical translation of OR-OAM technology.

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Section: Spadementioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Large-field-of-view optical-resolution optoacoustic microscopy using a stationary silicon-photonics acoustic detector

Harary,

Nagli,

Suleymanov

et al. 2024

J. Biomed. Opt.

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“… 5 , 6 In recent years, numerous research groups and companies have developed medical devices and processing systems available for human imaging. 1 , 2 , 6 – 8 Typically, PA imaging devices consist of several essential components, including a short-pulsed laser for generating PA signals, an ultrasonic transducer or transducer array for detecting PA signals, a data-acquisition system for amplifying and digitizing PA signals, and a computer for forming image. 1 , 6 …”

Section: Introductionmentioning

confidence: 99%

“…5,6 In recent years, numerous research groups and companies have developed medical devices and processing systems available for human imaging. 1,2,[6][7][8] Typically, PA imaging devices consist of several essential components, including a short-pulsed laser for generating PA signals, an ultrasonic transducer or transducer array for detecting PA signals, a data-acquisition system for amplifying and digitizing PA signals, and a computer for forming image. 1,6 As PA imaging merges laser-induced optical excitation with ultrasound (US) detection, it has advantages for clinical applications as follows: (1) PA imaging allows for noninvasive functional, metabolic, and histological imaging using endogenous contrasts such as hemoglobin [oxygenated hemoglobin (HbO 2 ), deoxygenated hemoglobin (Hb), total hemoglobin (HbT), also known as total blood volume (TBV)], lipids, and water (Fig.…”

Section: Introductionmentioning

confidence: 99%

Mini review of photoacoustic clinical imaging: a noninvasive tool for disease diagnosis and treatment evaluation

Liu,

Wang,

et al. 2024

J. Biomed. Opt.

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. Significance Photoacoustic (PA) imaging is an imaging modality that integrates anatomical, functional, metabolic, and histologic insights. It has been a hot topic of medical research and draws extensive attention. Aim This review aims to explore the applications of PA clinical imaging in human diseases, highlighting recent advancements. Approach A systemic survey of the literature concerning the clinical utility of PA imaging was conducted, with a particular focus on its application in tumors, autoimmune diseases, inflammatory conditions, and endocrine disorders. Results PA imaging is emerging as a valuable tool for human disease investigation. Information provided by PA imaging can be used for diagnosis, grading, and prognosis in multiple types of tumors including breast tumors, ovarian neoplasms, thyroid nodules, and cutaneous malignancies. PA imaging facilitates the monitoring of disease activity in autoimmune and inflammatory diseases such as rheumatoid arthritis, systemic sclerosis, arteritis, and inflammatory bowel disease by capturing dynamic functional alterations. Furthermore, its unique capability of visualizing vascular structure and oxygenation levels aids in assessing diabetes mellitus comorbidities and thyroid function. Conclusions Despite extant challenges, PA imaging offers a promising noninvasive tool for precision disease diagnosis, long-term evaluation, and prognosis anticipation, making it a potentially significant imaging modality for clinical practice.

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Silicon photonic acoustic detector (SPADE) using a silicon nitride microring resonator

Cited by 2 publications

References 46 publications

Large-field-of-view optical-resolution optoacoustic microscopy using a stationary silicon-photonics acoustic detector

Large-field-of-view optical-resolution optoacoustic microscopy using a stationary silicon-photonics acoustic detector

Mini review of photoacoustic clinical imaging: a noninvasive tool for disease diagnosis and treatment evaluation

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