Silicon nanowire-transistor biosensor for study of molecule-molecule interactions

Yang, Fan; Zhang, Guojun

doi:10.1515/nano.0040.00008

Cited by 6 publications

(7 citation statements)

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“…When a negatively charged antigen, molecule is attached to the surface, the charge carrier's depletion occurs in the complete cross-section of GFET that results in a decrease of electrical conductance and the drain current. Similarly, when a positively charged protein binds to a GFET biosensor, the conductance increases [11][12][13][14]. These properties can be demonstrated in COMSOL Multiphysics using the chemical reaction and transport of diluted spices modules, as well as the semiconductor module [15][16].…”

Section: : Design and Simulation Of Gfetmentioning

confidence: 99%

Design and Development of Graphene FET Biosensor for the Detection of SARS-CoV-2

Krsihna

Ahmadsaidulu²,

Teja³

et al. 2021

Preprint

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The most affected disease in recent years is Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) that is notable as COVID-19. It has been started as a disease in one place and arisen as a pandemic throughout the world. A serious health problem is developed in the lungs due to the effect of this coronavirus. Sometimes it may result in death as a consequence of extensive alveolar damage and progressive respiratory failure. Hence, early detection and appropriate diagnosis of corona virus in patient’s body is very essential to save the lives of affected patients This work evolves a Silicon (Si) based label-free electrical device i.e. the reduced graphene oxide field-effect transistor (rGO FET) for SARS-CoV-2 detection. Firstly rGO FET functionalized with SARS-CoV-2 monoclonal antibodies (mAbs). Then the rGO FET characteristic response is observed to detect the antibody-antigen reaction of SARS-CoV-2 with different molar ranges. The developed GFET shows better performance towards the drain current and limit-of-detection (LoD) up to 2E-18 M. Therefore, we believe that an intense response was observed than the earlier developed devices and signifies impressive capability for subsequent implementation in point-of-care (PoC) diagnostic tests.

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Section: : Design and Simulation Of Gfetmentioning

confidence: 99%

Design and Development of Graphene FET Biosensor for the Detection of SARS-CoV-2

Krsihna

Ahmadsaidulu²,

Teja³

et al. 2021

Preprint

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“…Optical systems include systems based on plasmon resonance [ 8 ], but these methods are limited by the concentration detection limit of the order of 10 −12 mol/L. Nanomechanical systems, intended for revelation of diseases, which allow one to attain femtomolar concentration detection limit, can be implemented on the basis of atomic force microscopes [ 10 ]; however, these systems have a drawback related to the detection time when the analysis takes several hours. The detection based on nanowire field-effect transistors seems to be the most promising in terms of the concentration detection limit ( DL ) as well as detection time.…”

Section: Introductionmentioning

confidence: 99%

“…The concentration detection limit, attainable using devices relying on silicon sensors that function as field-effect transistors (Si-NW-sensors) is several orders higher (~10 −15 –10 −18 M) [ 5 , 6 , 7 , 8 , 9 , 10 , 11 ], due to the nanometer scale of the sensor. In such sensor platforms, one Si-NW sensor is usually employed in the field-effect transistor as an electric channel between the source and the drain.…”

Section: Introductionmentioning

confidence: 99%

Use of Silicon Nanowire Sensors for Early Cancer Diagnosis

et al. 2021

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The review covers some research conducted in the field of medical and biomedical application of devices based on silicon sensor elements (Si-NW-sensors). The use of Si-NW-sensors is one of the key methods used in a whole range of healthcare fields. Their biomedical use is among the most important ones as they offer opportunities for early diagnosis of oncological pathologies, for monitoring the prescribed therapy and for improving the people’s quality of life.

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“…Nanowire (NW) biosensors represent one of the types of molecular detectors. Their use for the highly sensitive detection of various biomolecules [ 32 , 33 , 34 ] and viral particles [ 35 ] was previously demonstrated in a number of papers. These biosensors allow for label-free detection of biological macromolecules in real time with high sensitivity (at femtomolar and even subfemtomolar level).…”

Section: Introductionmentioning

confidence: 99%

Raman Spectroscopy-Based Quality Control of “Silicon-On-Insulator” Nanowire Chips for the Detection of Brain Cancer-Associated MicroRNA in Plasma

Malsagova

Popov

Kupriyanov

et al. 2021

Sensors

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Application of micro-Raman spectroscopy for the monitoring of quality of nanowire sensor chips fabrication has been demonstrated. Nanowire chips have been fabricated on the basis of «silicon-on-insulator» (SOI) structures (SOI-NW chips). The fabrication of SOI-NW chips was performed by optical litography with gas-phase etching. The so-fabricated SOI-NW chips are intended for highly sensitive detection of brain cancer biomarkers in humans. In our present study, two series of experiments have been conducted. In the first experimental series, detection of a synthetic DNA oligonucleotide (oDNA) analogue of brain cancer-associated microRNA miRNA-363 in purified buffer solution has been performed in order to demonstrate the high detection sensitivity. The second experimental series has been performed in order to reveal miRNA-363 itself in real human plasma samples. To provide detection biospecificity, the SOI-NW chip surface was modified by covalent immobilization of probe oligonucleotides (oDNA probes) complementary to the target biomolecules. Using the SOI-NW sensor chips proposed herein, the concentration detection limit of the target biomolecules at the level of 3.3 × 10−17 M has been demonstrated. Thus, the approach employing the SOI-NW chips proposed herein represents an attractive tool in biomedical practice, aimed at the early revelation of oncological diseases in humans.

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Silicon nanowire-transistor biosensor for study of molecule-molecule interactions

Cited by 6 publications

References 0 publications

Design and Development of Graphene FET Biosensor for the Detection of SARS-CoV-2

Design and Development of Graphene FET Biosensor for the Detection of SARS-CoV-2

Use of Silicon Nanowire Sensors for Early Cancer Diagnosis

Raman Spectroscopy-Based Quality Control of “Silicon-On-Insulator” Nanowire Chips for the Detection of Brain Cancer-Associated MicroRNA in Plasma

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