Silicon nanowire field-effect-transistor based biosensors: From sensitive to ultra-sensitive

Shen, Mo Yuan; Li, Bor‐Ran; Li, Yaw-Kuen

doi:10.1016/j.bios.2014.03.057

Cited by 147 publications

(100 citation statements)

References 98 publications

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“…Silicon nanowire (SiNW)-FETs with surface receptors binding into arrays are favorable for selective, highly sensitive, multiplexed and label-free biomarker measurements (7). The integrated control nanowires may further reduce the incidence of false-positive results.…”

Section: Nanowiresmentioning

confidence: 99%

Advances in the application of nanotechnology in the diagnosis and treatment of gastrointestinal tumors

Sun

Fang

et al. 2014

Molecular and Clinical Oncology

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Abstract. Nanotechnology has broad application prospects in the diagnosis and treatment of cancer. Integrating chemistry, engineering, biology and medicine, nanotechnology is a multidisciplinary research field. Nanoscale imaging technology significantly improves the precision and accuracy of tumor diagnosis. Nanocarriers are able to significantly improve the accuracy of dose and targeted drug delivery and reduce the toxic side effects. This review focuses on the emerging roles of these innovative technologies in gastrointestinal cancer diagnostics and therapeutics. Although several problems and barriers are hampering the development of nanodevices, the potential for nanotechnologies to function as multimodal nanotheranostic agents will likely pave the way for the fight against gastrointestinal cancer.

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Section: Nanowiresmentioning

confidence: 99%

Advances in the application of nanotechnology in the diagnosis and treatment of gastrointestinal tumors

Sun

Fang

et al. 2014

Molecular and Clinical Oncology

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“…In recent years, the significance of biological sensors using nanomaterials, such as silicon nanowires [7,8], carbon nanotubes [9,10], and graphene [11,12], has drawn significant attention to scientific research owing to its unique physical and chemical properties, such as surface effect and microsize effect. It is expected that these biosensors can be used as nextgeneration diagnostic chips for the future, which will play an increasingly important role in life science research and medical testing.…”

Section: Introductionmentioning

confidence: 99%

RNA Detection Based on Graphene Field-Effect Transistor Biosensor

Tian

Zhang

et al. 2018

Advances in Condensed Matter Physics

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Graphene has attracted much attention in biosensing applications due to its unique properties. In this paper, the monolayer graphene was grown by chemical vapor deposition (CVD) method. Using the graphene as the electric channel, we have fabricated a graphene field-effect transistor (G-FET) biosensor that can be used for label-free detection of RNA. Compared with conventional method, the G-FET RNA biosensor can be run in low cost, be time-saving, and be miniaturized for RNA measurement. The sensors show high performance and achieve the RNA detection sensitivity as low as 0.1 fM, which is two orders of magnitude lower than the previously reports. Moreover, the G-FET biosensor can readily distinguish target RNA from noncomplementary RNA, showing high selectivity for RNA detection. The developed G-FET RNA biosensor with high sensitivity, fast analysis speed, and simple operation may provide a new feasible direction for RNA research and biosensing.

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“…The device has increasingly attracted worldwide attention with its potential clinical applications. [19][20][21][22][23] correspondence: Tong Wang Department of endoscopy surgery, Wuxi People's Hospital Affiliated to Nanjing Medical University, 299 Qingyang road, Wuxi 214023, People's republic of china Tel +86 510 8270 0778 email aanti@163.com…”

Section: Introductionmentioning

confidence: 99%

Top-down nanofabrication of silicon nanoribbon field effect transistor (Si-NR FET) for carcinoembryonic antigen detection

Bao¹,

Sun²,

Zhao³

et al. 2017

IJN

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Sensitive and quantitative detection of tumor markers is highly required in the clinic for cancer diagnosis and consequent treatment. A field-effect transistor-based (FET-based) nanobiosensor emerges with characteristics of being label-free, real-time, having high sensitivity, and providing direct electrical readout for detection of biomarkers. In this paper, a top–down approach is proposed and implemented to fulfill a novel silicon nano-ribbon FET, which acts as biomarker sensor for future clinical application. Compared with the bottom–up approach, a top–down fabrication approach can confine width and length of the silicon FET precisely to control its electrical properties. The silicon nanoribbon (Si-NR) transistor is fabricated on a Silicon-on-Insulator (SOI) substrate by a top–down approach with complementary metal oxide semiconductor (CMOS)-compatible technology. After the preparation, the surface of Si-NR is functionalized with 3-aminopropyltriethoxysilane (APTES). Glutaraldehyde is utilized to bind the amino terminals of APTES and antibody on the surface. Finally, a microfluidic channel is integrated on the top of the device, acting as a flowing channel for the carcinoembryonic antigen (CEA) solution. The Si-NR FET is 120 nm in width and 25 nm in height, with ambipolar electrical characteristics. A logarithmic relationship between the changing ratio of the current and the CEA concentration is measured in the range of 0.1–100 ng/mL. The sensitivity of detection is measured as 10 pg/mL. The top–down fabricated biochip shows feasibility in direct detecting of CEA with the benefits of real-time, low cost, and high sensitivity as a promising biosensor for tumor early diagnosis.

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Silicon nanowire field-effect-transistor based biosensors: From sensitive to ultra-sensitive

Cited by 147 publications

References 98 publications

Advances in the application of nanotechnology in the diagnosis and treatment of gastrointestinal tumors

Advances in the application of nanotechnology in the diagnosis and treatment of gastrointestinal tumors

RNA Detection Based on Graphene Field-Effect Transistor Biosensor

Top-down nanofabrication of silicon nanoribbon field effect transistor (Si-NR FET) for carcinoembryonic antigen detection

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