Silicon Nanoparticles Formed via Pulsed Laser Ablation of Porous Silicon in Liquids

Skobelkina, A. V.; Kashaev, F. V.; Kolchin, A. V.; Shuleiko, D. V.; Kaminskaya, T. P.; Presnov, D. E.; Golovan, L. V.; Кашкаров, П. К.

doi:10.1134/s1063785020070263

Cited by 11 publications

(9 citation statements)

References 10 publications

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“…Fabricating SiNPs by pulsed laser ablation of silicon nanowires [34] or porous silicon [35] in liquids represents a way to control SiNPs size through the selection of buffer liquid (water, ethanol, liquid helium) and pulse duration [36]. Additionally, the wavelength of ablating radiation affects the SiNPs size, insofar as the scattering and absorption properties of an ablation target depend on it.…”

Section: Introductionmentioning

confidence: 99%

“…SiNW arrays fabricated via a metal-assisted chemical etching technique [46] contain SiNWs of about 100 nm in diameter and up to 100 µm in length which demonstrate strong scattering and high absorption of visible and near-infrared light [47,48]. Ablation threshold of SiNWs is up to eight times lower than in crystalline silicon [34,35], which increases product yield and reduces the estimated production cost. However, to our knowledge, the laser-ablated SiNWs have not been reported to be used in photohyperthermia.…”

Section: Introductionmentioning

confidence: 99%

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Numerical Simulation of Enhancement of Superficial Tumor Laser Hyperthermia with Silicon Nanoparticles

et al. 2021

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Biodegradable and low-toxic silicon nanoparticles (SiNPs) have potential in different biomedical applications. Previous experimental studies revealed the efficiency of some types of SiNPs in tumor hyperthermia. To analyse the feasibility of employing SiNPs produced by the laser ablation of silicon nanowire arrays in water and ethanol as agents for laser tumor hyperthermia, we numerically simulated effects of heating a millimeter-size nodal basal-cell carcinoma with embedded nanoparticles by continuous-wave laser radiation at 633 nm. Based on scanning electron microscopy data for the synthesized SiNPs size distributions, we used Mie theory to calculate their optical properties and carried out Monte Carlo simulations of light absorption inside the tumor, with and without the embedded nanoparticles, followed by an evaluation of local temperature increase based on the bioheat transfer equation. Given the same mass concentration, SiNPs obtained by the laser ablation of silicon nanowires in ethanol (eSiNPs) are characterized by smaller absorption and scattering coefficients compared to those synthesized in water (wSiNPs). In contrast, wSiNPs embedded in the tumor provide a lower overall temperature increase than eSiNPs due to the effect of shielding the laser irradiation by the highly absorbing wSiNPs-containing region at the top of the tumor. Effective tumor hyperthermia (temperature increase above 42 °C) can be performed with eSiNPs at nanoparticle mass concentrations of 3 mg/mL and higher, provided that the neighboring healthy tissues remain underheated at the applied irradiation power. The use of a laser beam with the diameter fitting the size of the tumor allows to obtain a higher temperature contrast between the tumor and surrounding normal tissues compared to the case when the beam diameter exceeds the tumor size at the comparable power.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Numerical Simulation of Enhancement of Superficial Tumor Laser Hyperthermia with Silicon Nanoparticles

et al. 2021

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“…Optical properties of pure black ink and Intralipid were obtained from spectrophotometric measurements using Specord 250 PLUS spectrophotometer equipped with an integrating sphere (Analytik Jena, Germany). The values of µ s (λ) and µ a (λ) were reconstructed from the measured diffuse transmittance and reflectance by inverse Monte Carlo technique [31]. Optical properties of the prepared phantom were also verified by the spectrophotometric measurements and inverse Monte Carlo reconstruction.…”

Section: Phantom In Vitro and In Vivo Protocolsmentioning

confidence: 99%

Quantitative techniques for extraction of blood oxygenation from multispectral optoacoustic measurements

et al. 2019

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We report on the comparison of two approaches to the reconstruction of oxygen saturation (StO 2 ) within blood vessels from multispectral optoacoustic (OA) measurements. The spatially-resolving approach is based on determination of the optical absorption coefficient µ a from OA signal amplitudes, while the calibration-free approach is based on evaluation of the effective optical attenuation coefficient µ eff derived from the in-depth OA signal decay. Both approaches were verified in phantom experiments as well as in in vitro and in vivo measurements. The results demonstrate good agreement of µ a spectra derived from OA signal amplitudes with the published data indicating this approach to be preferable for the in vivo determination of StO 2 . Reconstruction of µ a spectra from the in vivo measured OA signal amplitudes in a rat yields StO 2 values of 0.57 ± 0.08 and 0.50 ± 0.07 for two veins of the thoracic spine. We demonstrate that for cost-effective measurements a dual-probing wavelength scheme can be employed instead of multiple wavelength probing. We found that the probing wavelength of 700 nm combined with a wavelength from the range of 850-1069 nm provides reconstructed StO 2 values close to the reference ones derived from multiple wavelength measurements in the entire range of 658-1069 nm.

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“…Noteworthy, similar scalable reduction of the incident threshold fluence was found for picosecondlaser ablation of p-Si/c-Si targets. 51,52 Recent theoretical assessments based on molecular dynamic simulations revealed only about a 10% lower melting threshold (absorbed fluence) for p-Si material in comparison to those for crystalline target, 53 indicating the validity of the chosen fluence. Under such reduced fluence, the LAL synthesis of the p-Si NPs appears to be a self-terminated process that ends up when the laser radiation reaches the bottom of the 150 μm thick porous layer (see Figure 1b).…”

Section: ■ Introductionmentioning

confidence: 99%

Au–Si Nanocomposites with High Near-IR Light-to-Heat Conversion Efficiency via Single-Step Reactive Laser Ablation of Porous Silicon for Theranostic Applications

Gurbatov,

Zhizhchenko,

Nesterov

et al. 2024

ACS Appl. Nano Mater.

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Hybrid nanoparticles (NPs) with complex morphology, structure, and chemical composition are considered key building blocks of next-generation optoelectronic devices, catalysts, and sensitizers/agents for diverse biomedical applications. Laser ablation in liquid (LAL) has emerged as a promising route to design and produce unique nanocomposite NPs, yet control over the product's size and structure is limited by tuning laser parameters or the content of the surrounding liquid. In this paper, based on the example of porous Si prepared by electrochemical etching, we demonstrate an alternative route to control the size of the resulting NPs through the modification of the target material's porosity. In particular, we showed a 3-fold size reduction of the LAL-synthesized Si NPs as compared to the product obtained by the ablation of the common monocrystalline Si wafer. The produced nanocrystalline Si NPs demonstrate a narrow monomodal size distribution with an average diameter of around 200 nm, which cover a practically relevant size range, allowing the excitation of Mie resonances at visible and near-IR wavelengths. Moreover, by adding a certain controlled amount of acid metal precursor HAuCl 4 , we fabricated core−satellites and nanocomposite Au−Si NPs via similar facile single-pot reactive laser synthesis. The incorporation of Au into the Si NPs was found to enhance the near-IR light-to-heat conversion performance of the nanohybrids, as confirmed by numerical modeling and single-particle micro-Raman thermometry at 785 nm wavelength matching the NIR-I biological transparency window. The obtained results pave the way toward the milligram-scale production of pure and hybrid Si-based Mie-resonant NPs for photonic, optoelectronic, sensing, and biomedical applications, while highlighting additional degree of freedom for control over the obtained product characteristics.

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Silicon Nanoparticles Formed via Pulsed Laser Ablation of Porous Silicon in Liquids

Cited by 11 publications

References 10 publications

Numerical Simulation of Enhancement of Superficial Tumor Laser Hyperthermia with Silicon Nanoparticles

Numerical Simulation of Enhancement of Superficial Tumor Laser Hyperthermia with Silicon Nanoparticles

Quantitative techniques for extraction of blood oxygenation from multispectral optoacoustic measurements

Au–Si Nanocomposites with High Near-IR Light-to-Heat Conversion Efficiency via Single-Step Reactive Laser Ablation of Porous Silicon for Theranostic Applications

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