Silicon-containing nanomedicine and biomaterials: materials chemistry, multi-dimensional design, and biomedical application

Chen, Liang; Zhang, Shanshan; Duan, Yanqiu; Song, Xinran; Chang, Meiqi; Feng, Wei; Chen, Yu

doi:10.1039/d1cs01022k

Cited by 11 publications

(2 citation statements)

References 1,475 publications

(1,931 reference statements)

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“…Moreover, the possibility of incorporating bioactive molecules, metabolites, and growth factors into the bio-glass further accelerates the healing process and helps to mitigate the risk of infections and post-implantation inflammation [8][9][10]. These loaded systems avoid implant rejections through a controlled drug release at the implantation site [11].…”

Section: Introductionmentioning

confidence: 99%

Effect of Nitric Acid on the Synthesis and Biological Activity of Silica–Quercetin Hybrid Materials via the Sol-Gel Route

D’Angelo,

Fiorentino,

Viola

et al. 2024

Applied Sciences

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The sol-gel technique stands out as a valuable method for synthesizing biomaterials and encapsulating bioactive molecules, offering potential for controlled drug release and tissue regeneration in biomedical contexts. This study focused on synthesizing silica (Si)-based hybrid biomaterials containing 5% quercetin (Q5) using two different approaches: one involving nitric acid as a catalyst (SiQ5-HNO3) and the other being acid-free (SiQ5). Structural characterization using Fourier transform infrared (FTIR) and UV-vis spectroscopy revealed oxidation processes compromising the structural integrity of quercetin in both systems. However, it was observed that these oxidation processes led to the formation of oxidized derivatives of quercetin with distinct structures. Additionally, the bioactivity and release kinetics of quercetin from the silica matrices were evaluated, showing that both systems were capable of forming hydroxyapatite, indicating excellent bioactivity. Furthermore, SiQ5 exhibited a higher percentage release of the encapsulated drug at pH 7.4, representing the physiological environment, compared to SiQ5-HNO3, with a drastic reduction in drug release observed at pH 5.0 (cancer environment). Antibacterial efficacy assessment using the Kirby–Bauer test highlighted the greater antibacterial activity of the SiQ5-HNO3 system against all tested strains. Overall, this research aims to advance the development of more effective biomaterials for various biomedical applications, particularly in tissue engineering and infection control.

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Section: Introductionmentioning

confidence: 99%

Effect of Nitric Acid on the Synthesis and Biological Activity of Silica–Quercetin Hybrid Materials via the Sol-Gel Route

D’Angelo,

Fiorentino,

Viola

et al. 2024

Applied Sciences

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“…1–4 One sub-group in these hybrid structures is bioactive glass (BG)/polymer hybrids, which have been extensively studied, especially for their potential applications in bone tissue engineering and wound healing. 5–14…”

Section: Introductionmentioning

confidence: 99%

Temperature-responsive bioactive glass/polymer hybrids allow for tailoring of ion release

Nabiyan,

Jin,

Brauer

2024

Soft Matter

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In vivo safety evaluation method for nanomaterials for cancer therapy

Chen,

Hei,

Huang

et al. 2024

Clin Transl Oncol

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Silicon-containing nanomedicine and biomaterials: materials chemistry, multi-dimensional design, and biomedical application

Abstract: Silicon-based biomaterials have been extensively developed in the past decades. The classification, characteristics, multi-dimensional design, and biomedical applications of silicon-containing biomaterials are comprehensively elaborated.

Cited by 11 publications

References 1,475 publications

Effect of Nitric Acid on the Synthesis and Biological Activity of Silica–Quercetin Hybrid Materials via the Sol-Gel Route

Effect of Nitric Acid on the Synthesis and Biological Activity of Silica–Quercetin Hybrid Materials via the Sol-Gel Route

Temperature-responsive bioactive glass/polymer hybrids allow for tailoring of ion release

In vivo safety evaluation method for nanomaterials for cancer therapy

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