Silicon-calcium phosphate ceramics and silicon-calcium phosphate cements: Substrates to customize the release of antibiotics according to the idiosyncrasies of the patient

Lucas-Aparicio, Julia; Manchón, Ángel; Rueda, Carmen; Pintado, Concepción; Torres, J. T. Resendiz; Alkhraisat, Mohammad Hamdan; López-Cabarcos, Enrique

doi:10.1016/j.msec.2019.110173

Cited by 12 publications

(8 citation statements)

References 47 publications

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“… 102 For the treatment of infection, an initial burst of antibacterial and anti-inflammatory drugs is released at the implant site to effectively inhibit microbes, ideally in controlled amounts to avoid toxicity or bacterial resistance, and sustained release then continues at low concentrations. 97 , 103 , 104 It is worth noting that in most calcium phosphate materials, there are two release concentration gradients, namely, the initial fast release period and the subsequent slow release period. 76 , 105 Under actual experimental conditions, the drug release kinetics conformed to the Korsmeyer-Peppas equation and the port mode.…”

Section: Drug-loaded Bone Scaffoldsmentioning

confidence: 99%

Research Progress of Design Drugs and Composite Biomaterials in Bone Tissue Engineering

Guo¹,

Song²,

Lu³

et al. 2023

IJN

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Bone, like most organs, has the ability to heal naturally and can be repaired slowly when it is slightly injured. However, in the case of bone defects caused by diseases or large shocks, surgical intervention and treatment of bone substitutes are needed, and drugs are actively matched to promote osteogenesis or prevent infection. Oral administration or injection for systemic therapy is a common way of administration in clinic, although it is not suitable for the long treatment cycle of bone tissue, and the drugs cannot exert the greatest effect or even produce toxic and side effects. In order to solve this problem, the structure or carrier simulating natural bone tissue is constructed to control the loading or release of the preparation with osteogenic potential, thus accelerating the repair of bone defect. Bioactive materials provide potential advantages for bone tissue regeneration, such as physical support, cell coverage and growth factors. In this review, we discuss the application of bone scaffolds with different structural characteristics made of polymers, ceramics and other composite materials in bone regeneration engineering and drug release, and look forward to its prospect.

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Section: Drug-loaded Bone Scaffoldsmentioning

confidence: 99%

Research Progress of Design Drugs and Composite Biomaterials in Bone Tissue Engineering

Guo¹,

Song²,

Lu³

et al. 2023

IJN

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“…The authors discussed only n values, while the comparison of the k parameter (20–43 for adsorbed DOXY hyclate and 9–20 for DOXY hyclate in the setting solution) was left unaddressed, even though it agrees with the experimental data, confirming the more hampered dissolution of the drug from the bulk of the cements for the second loading method. A similar concept was adopted in a recent work by Lucas-Aparicio et al [ 53 ] where vancomycin was loaded into a silicon-CPC by the following two ways: 1) adsorption of the drug from a drug-containing solution or 2) loading the drug in a solid state during the cement preparation stage. Due to the fact that this work attempted to assess the effects of multiple factors on the drug release, including the Si content within the cement matrix, the drug concentration and the loading method, it must be premised that in the frame of such an exhaustive experimental design, it was hard to isolate the effects caused by one variable at a time.…”

Section: Drug Loading Methodsmentioning

confidence: 99%

“…The experimental evidence revealed a parallel increase in the release rate for both drugs and the porosity, which increased with the relative amount of HAp2 in the hybrid cements. In a recent work from 2020 by Lucas-Aparicio et al [ 53 ], a TCP-based CPC with an extensive accommodation of Si in the matrix was studied as a potential carrier of drugs able to provide a constant release with the minimal burst effect. Characterizations were conducted on the cements with different amounts of Si: 0, 40 and 80% of the stoichiometric Si substitution.…”

Section: Porosity and Pore Featuresmentioning

confidence: 99%

“…This could be the result of the detachment of the fragments of DOXY hyclate adsorbed on the cement surface, which occurs to a greater extent at high concentrations of the drug. A similar approach was adopted for an article from 2020 by Lucas-Aparicio et al [ 53 ]. A series of experiments was conducted to assess the release of vancomycin at the concentrations of 5 and 10 mg/ml from Si-substituted CPCs, with the [Si/(Si + P)] atomic ratios of 40% and 80%.…”

Section: Drug Concentrationmentioning

confidence: 99%

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Factors influencing the drug release from calcium phosphate cements

Fosca

Rau

Uskoković³

2022

Bioactive Materials

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Thanks to their biocompatibility, biodegradability, injectability and self-setting properties, calcium phosphate cements (CPCs) have been the most economical and effective biomaterials of choice for use as bone void fillers. They have also been extensively used as drug delivery carriers owing to their ability to provide for a steady release of various organic molecules aiding the regeneration of defective bone, including primarily antibiotics and growth factors. This review provides a systematic compilation of studies that reported on the controlled release of drugs from CPCs in the last 25 years. The chemical, compositional and microstructural characteristics of these systems through which the control of the release rates and mechanisms could be achieved have been discussed. In doing so, the effects of (i) the chemistry of the matrix, (ii) porosity, (iii) additives, (iv) drug types, (v) drug concentrations, (vi) drug loading methods and (vii) release media have been distinguished and discussed individually. Kinetic specificities of in vivo release of drugs from CPCs have been reviewed, too. Understanding the kinetic and mechanistic correlations between the CPC properties and the drug release is a prerequisite for the design of bone void fillers with drug release profiles precisely tailored to the application area and the clinical picture. The goal of this review has been to shed light on these fundamental correlations.

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“…CaPs have been widely used as bone fillers in orthopedic and maxillofacial applications, osteosarcoma, and osteoporosis. The addition of drugs in CaPs biomaterials to be delivered locally can prevent or treat bone diseases and accelerate tissue recovery [18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Crystallization of carboplatin-loaded onto microporous calcium phosphate using high-vacuum method: Characterization and release study

2020

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Drug delivery systems are a new approach to increase therapeutic efficacy and to reduce the side effects of traditional treatments. Calcium phosphates (CaPs) have been studied as drug delivery systems, especially in bone diseases. However, each system has some particularities that depend on the physical and chemical characteristics of the biomaterials and drug interaction. In this work, granulated CaPs were used as a matrix for loading the anticancer drug carboplatin using the high-vacuum method. Five compositions were applied: hydroxyapatite (HA), β-tricalcium phosphate (β-TCP), biphasic HAp 60%/β-TCP 40% (BCP), β-TCP/MgO nanocomposite, and β-TCP/SiO2 nanocomposite. Carboplatin drug in 50, 60, and 70 mg/g was precipitated on the surface of CaPs. Morphological, chemical and surface modifications in the carboplatin-CaPs were investigated by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), backscattered electron microscopy (BSE), X-ray diffraction (XRD), X-ray fluorescence spectroscopy (XRF), Fourier transform infrared (FT-IR), and Raman spectroscopy. The characterization of the CaP-carboplatin biomaterials showed heterogeneous crystalline precipitation of the drug, and no morphological modifications of the CaPs biomaterials. The in vitro release profile of carboplatin from CaPs was evaluated by the ultraviolet-visible (UV-Vis) method. The curves showed a burst release of upon 60% of carboplatin loaded followed by a slow-release of the drug for the time of the study. The results were typical of a low-interaction system and physisorption mechanism. The high-vacuum method permitted to load the high amount of carboplatin drug on the surface of the biomaterials despite the low interaction between carboplatin and CaPs.

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Silicon-calcium phosphate ceramics and silicon-calcium phosphate cements: Substrates to customize the release of antibiotics according to the idiosyncrasies of the patient

Cited by 12 publications

References 47 publications

Research Progress of Design Drugs and Composite Biomaterials in Bone Tissue Engineering

Research Progress of Design Drugs and Composite Biomaterials in Bone Tissue Engineering

Factors influencing the drug release from calcium phosphate cements

Crystallization of carboplatin-loaded onto microporous calcium phosphate using high-vacuum method: Characterization and release study

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