Silicon-Based Scaffold for Wound Healing Skin Regeneration Applications: A Concise Review

Abstract

Silicon has made its breakthrough in various industries, including clinical and biomedical applications. Silicon-based biomaterials that were fabricated into various types of scaffolds may attract interest due to their highly favorable properties covering their excellent biocompatibility, high surface area, mechanical strength, and selectivity depending on their application including film, hydrogel, nanoparticles, and so on. Silicon-based materials have also shown exciting results involving cell culture, cell growth, as well as tissue engineering. In this article, a simple review compromising the evaluation of silicon’s unique properties has been discussed and followed by the application of the silicone-based product in future perspectives in biomedical fields. The review goals are to widen and inspire broader interest in silicone-based materials in wound healing research.

Self-Healing Silicone Materials: Looking Back and Moving Forward

“…Thus, similar antibacterial self–healing materials are very promising in the field of biomedicine [ 156 ] as, for example, antibacterial coatings and surfaces for operation hospitals, veterinary clinics, as well as the food industry [ 145 ].…”

Characterization of Dual-Layer Hybrid Biomatrix for Future Use in Cutaneous Wound Healing

“…A biomatrix is usually a porous three-dimensional (3D) scaffold that provides an appropriate surrounding microenvironment, especially for regenerating tissues and organs [ 1 , 2 , 3 ]. Each 3D-scaffold should provide properties as such: architecture and mechanical strength, composition of the biomaterial, which will determine the cellular interaction’s efficacy, functions in tissue regeneration along with effective host tissues integration [ 4 , 5 ]. Thus, biomaterials from synthetic and natural polymers have been widely explored for biomatrix fabrication to satisfy these properties.…”