Silica xerogels as pharmaceutical drug carriers

Nitric Oxide-Releasing Xerogels Synthesized from N-Diazeniumdiolate-Modified Silane Precursors

“…18, 21, 24 Careful selection of organically modified precursors provides a route to control surface area, pore structure, and hydrophobicity. 25 These attributes allow for the release of NO (and other therapeutic agents) 26,27,28 from the xerogel network while simultaneously allowing diffusion of external species into the xerogel. Coupling the beneficial attributes of NO release with glucose sensor membranes has thus been proposed as a means for developing more functional sensors.…”

Synthesis and characterisation of Gossypium hirsutum seeds extract nanoencapsulated in silica microparticles

“…For biomedical applications, it is desirable to have amorphous compounds, based on the fact that amorphous silica particles are considered less toxic than crystalline particles [2,37]. Moreover, amorphous structure offers a high physical stability to the assembly [38].…”

“…In recent years, the interest for sol-gel-derived materials intensely increased due to their flexible synthesis protocol allowing the control of morphology, porosity and size of particles [1][2][3][4][5][6][7]. These materials can be efficiently exploited as matrices for different pharmaceutically active compounds [8].…”

Ordered nanoporous silica as carriers for improved delivery of water insoluble drugs: a comparative study between three dimensional and two dimensional macroporous silica

“…[10][11][12][13][14] Porous silicate is a porous material that has been commonly used as a pharmaceutical excipient. Several grades of porous silicate having different characteristics such as particle size, pore size, and specific surface area are commercially available and have been widely employed to encapsulate poorly soluble drugs, such as Aerosil [15][16][17][18] Since the discovery of mesoporous (2 nm ,pore size ,50 nm) silica materials in the 1990s, the synthesis and application of mesoporous silica have received substantial attention due to their high surface area, well defined and tunable pore size, uniform porous structure, and easily modified surface. [19][20][21][22] Among these mesoporous silica, Mobil Composition of Matter (MCM)-41 and Santa Barbara Amorphous (SBA)-15 , with a two dimensionally ordered hexagonal arrangement of cylindrical pores of uniform size (typically 2-10 nm) disposed parallel to each other ( Figure 1A), are probably the most investigated materials.…”