Silica supported Fe(HSO4)3 as an efficient, heterogeneous and recyclable catalyst for synthesis of β-enaminones and β-enamino esters

Design of a graphene oxide-SnO2 nanocomposite with superior catalytic efficiency for the synthesis of β-enaminones and β-enaminoesters

“…These chemicals are a highly multifaceted class of intermediates for the synthesis of heterocyclic and biologically active compounds. The conventional synthesis protocols used for benaminones and b-enaminoesters involved condensation of carbonyl compounds with amines catalyzed by chlorides, 17,18 metal oxides, 19 aurates, 20 SiO 2 and it's composite, 16,[21][22][23] ionic liquids, 24 and triates. In particular, the enaminones and enaminoester moieties have attracted much interest, because they are fundamental and versatile starting materials for the synthesis of heterocycles, 3 alkaloids, 4,5 g-amino alcohol, 6 quinolines, 7 azocompounds 8 and a,b-amino acids.…”

1,3-Diketones. Synthesis and properties

“…As proposed in [88], the α-CH 2 group participates in the stabilization of intermediate 1,3-Bis-silyl ethers 136a and 136b derived from acetylacetone and benzoylacetone, respectively, reacted with benzoyl chloride to give 2-benzoyl derivatives; the reaction of 136a with isophthaloyl dichloride afforded the corresponding bis-triketone [90] (Scheme 84). Unsymmetrical β-diketones can be converted into 1,4-diketones 137 and trans-1,2-disubstituted cyclopropanols 138a and 138b according to one-pot procedure utilizing organozinc compounds [91].…”

“…One-pot reaction of β-diketones with para-substituted anilines, catalyzed by silica ferric hydrogen sulfate, under solvent-free conditions at room temperature gave 80-95% of β-enaminones 135 [88]. As proposed in [88], the α-CH 2 group participates in the stabilization of intermediate 1,3-Bis-silyl ethers 136a and 136b derived from acetylacetone and benzoylacetone, respectively, reacted with benzoyl chloride to give 2-benzoyl derivatives; the reaction of 136a with isophthaloyl dichloride afforded the corresponding bis-triketone [90] (Scheme 84).…”

One-Pot Synthesis, X-ray Single Crystal and Molecular Insight of Enaminone-Based β-Morpholino-/N-Methylpiperazinyl-/Pyrrolidinylpropiophenone

“…Many synthetic routes have been used for the synthesis of this special scaffold. Several catalysts such as InBr 3 [15], vanadium (IV) acetylacetonate [16], LaCl 3 [17], (CuI-2,2 -bipyridine-NaOtBu) [18], silica supported Fe(HSO 4 ) 3 under solvent free conditions [19], silver nanoparticles [20], and bimetallic Ag-Cu alloy nanoparticles [21], etc. have all been employed in direct synthetic methods of the Ag-Cu alloy nanoparticles [21], etc.…”