Silica nanoparticles aggravated the metabolic associated fatty liver disease through disturbed amino acid and lipid metabolisms-mediated oxidative stress

Abulikemu, Alimire; Zhao, Xinying; Xu, Hailin; Li, Yan; Ma, Ru; Yao, Qing; Wang, Ji; Sun, Zhiwei; Li, Yanbo; Guo, Caixia

doi:10.1016/j.redox.2022.102569

Cited by 46 publications

(16 citation statements)

References 110 publications

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“…Periodic acid-Schiff ( PAS ) and Oil Red O staining were executed as previously described ( Abulikemu et al, 2023 ). The kidney tissues of chickens were soaked in 4% paraformaldehyde, embedded in paraffin blocks, cut into 5 μm thickness, and then stained with Oil red O staining kit and PAS staining kit (Beyotime, Shanghai, China).…”

Section: Methodsmentioning

confidence: 99%

Luteolin alleviates cadmium-induced metabolism disorder through antioxidant and anti-inflammatory mechanisms in chicken kidney

Wang,

Zhang,

Ali

et al. 2024

Poultry Science

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Section: Methodsmentioning

confidence: 99%

Luteolin alleviates cadmium-induced metabolism disorder through antioxidant and anti-inflammatory mechanisms in chicken kidney

Wang,

Zhang,

Ali

et al. 2024

Poultry Science

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“…The presence of SiNPs had a significant impact on the hepatic metabolic profile of ApoE mice, particularly affecting amino acid and lipid metabolism. 44 In conclusion, the impact of nanomaterials on the body remains a significant aspect that we cannot ignore.…”

Section: Applications Of Omics Techniques In Assessing the Safety Of ...mentioning

confidence: 99%

Nano‐omics: Frontier fields of fusion of nanotechnology

Wang,

Xu,

et al. 2023

Smart Medicine

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“…The liver is the main site of fatty acid synthesis through fatty acid synthase FAS and ATP citrate lyase and is a major site of β-oxidation. 33 After exposure to propofol, the level of T-CHO in the liver of zebrafish was considerably upregulated, which increased the liver lipid dose and finally led to disordered liver lipid metabolism. HDL-C transports cholesterol back to the liver through blood circulation, where it is converted and metabolized.…”

Section: Propofol-induced Lipid Metabolismmentioning

confidence: 99%

Environmentally Relevant Concentrations of Propofol-Induced Metabolic Dysfunction in Zebrafish: Mechanistic Insights into Integrated Hepatic Transcriptomic and Metabolomic Analyses

Jiang,

Li,

Zhang

et al. 2024

ACS EST Water

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Propofol is increasingly perceived as an emerging threat to aquatic ecosystems, although the ecotoxicity and underlying mechanisms of propofol on aquatic life have not yet been clearly established. In this study, zebrafish (Danio rerio) was exposed to different concentrations of propofol (0.008, 0.04, and 0.2 mg•L −1 ) to probe the effect of propofol on functional metabolism and the ecological response mechanism in aquatic organisms. Propofol induced severe hepatic damage, including increased interstitial spaces and nuclear malformations at the tissue level. Reactive oxygen species (ROS) production and lipid peroxidation in zebrafish were induced after 28 days of exposure, while the activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were substantially increased, suggesting that propofol may influence hepatic tissue injury through exacerbating oxidative damage. Exacerbated levels of triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) were indicative of dysregulated lipid metabolism. Comprehensive transcriptomics and metabolomics analyses showed that propofol mainly changed the glycerophospholipid metabolism, citric acid cycle, and purine metabolism, and the disorders of these pathways can aggravate lipid accumulation and oxidative damage. Overall, this study revealed the mechanisms of hepatotoxicity and metabolic dysfunction of propofol on zebrafish, providing constructive insights for a comprehensive assessment of the toxicity risk posed by propofol to aquatic environmental health.

show abstract

Silica nanoparticles aggravated the metabolic associated fatty liver disease through disturbed amino acid and lipid metabolisms-mediated oxidative stress

Cited by 46 publications

References 110 publications

Luteolin alleviates cadmium-induced metabolism disorder through antioxidant and anti-inflammatory mechanisms in chicken kidney

Luteolin alleviates cadmium-induced metabolism disorder through antioxidant and anti-inflammatory mechanisms in chicken kidney

Nano‐omics: Frontier fields of fusion of nanotechnology

Environmentally Relevant Concentrations of Propofol-Induced Metabolic Dysfunction in Zebrafish: Mechanistic Insights into Integrated Hepatic Transcriptomic and Metabolomic Analyses

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