Silica–MOF Composites as a Stationary Phase in Liquid Chromatography

Ameloot, Rob; Liekens, Anuschka; Alaerts, Luc; Maes, M.; Galarneau, Anne; Coq, Bernard; Desmet, Gert; Sels, Bert F.; Denayer, Joeri; Vos, Dirk De

doi:10.1002/ejic.201000494

Cited by 127 publications

(93 citation statements)

References 27 publications

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“…By solvothermal reaction of HKUST-1 precursor solution in the presence of silica microspheres, HKUST-1 particles were formed and attached firmly on the silica spheres with adjustable porosity. 41,42 The SIM-1/alumina spheres formed by in-situ growth of SIM-1 (a substituted imidazolate-based MOF) onto α or γ-alumina beads under mild heating conditions was reported by S. Aguado et al (Figure 2a). 43 Interestingly, the SIM-1 crystals cover on the α-alumina bead to form a core-shell type structure while the majority of the MOF crystals resides within the cavities of the support when γ-alumina was used.…”

Section: In-situ Growth Of Mofs In the Matricesmentioning

confidence: 70%

Metal–organic framework composites: from fundamentals to applications

2015

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Metal-organic frameworks (MOFs) are a class of crystallized porous polymeric materials consisting of metal ions or clusters linked together by organic bridging ligands. Due to their permanent porosity, rich surface chemistry and tuneable pore sizes, MOFs have emerged as one type of important porous solid and have attracted intensive interests in catalysis, gas adsorption, separation and storage over the past two decades. When compared with pure MOFs, the combination of MOFs with functional species or matrix materials not only shows enhanced properties, but also broadens the applications of MOFs in new fields, such as bio-imaging, drug delivery and electrical catalysis, owing to the interactions of the functional species/matrix with the MOF structures. Although the synthesis, chemical modification and potential applications of MOFs have been reviewed previously, there is an increasing awareness on the synthesis and applications of their composites, which have rarely been reviewed. This review aims to fill this gap and discuss the fabrication, properties, and applications of MOF composites. The remaining challenges and future opportunities in this field, in terms of processing techniques, maximizing composite properties, and prospects for applications, have also been indicated.

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Section: In-situ Growth Of Mofs In the Matricesmentioning

confidence: 70%

Metal–organic framework composites: from fundamentals to applications

2015

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“…S21 †). The C 14 Gua-HKUST-1 column has a consistent elution order and faster elution times for the two analytes (1.7 min for ethylbenzene and 2.9 min for styrene) compared to the analogous HKUST-1 control column and a recently reported HKUST-1@silica composite column, 27 however the separation is not as pronounced for C 14 Gua-HKUST-1. The increased adsorption kinetics for C 14 Gua-HKUST-1 are due to the surface features arising from interactions with the C 14 Gua surfactants during synthesis, which results in a 25% reduction of column backpressure from 240 bars (smooth HKUST-1) to 187 bars.…”

Section: Chromatography With Surface-patterned C 14 Gua-hkust-1mentioning

confidence: 75%

Surface etching of HKUST-1 promoted via supramolecular interactions for chromatography

et al. 2014

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The addition of guanidinium-based surfactants to the synthesis of HKUST-1 reveals a novel surface patterning effect where meso-and macroscopic features appear on the MOF crystals. The size of the features increases with increasing alkyl chain length of the guanidinium amphiphiles, and their formation is strongly dependent on the presence of water which appears to more favourably etch the crystal surfaces when the surfactants are employed. The patterned crystals display intermediate type I/IV isotherms and the presence of the surface features have been evaluated for the chromatographic separation of styrene and ethylbenzene. Some degree of control over the interactions between the framework building blocks and the amphiphiles is afforded, and by simply changing the order of addition of the reactants the guanidinium surfactants promote the formation of HKUST-1 nanoparticles.

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“…30 SilicaÀCu 3 (BTC) 2 composites as the stationary phase for HPLC separation of EB and styrene have also been investigated. 31 Many MOFs are available now with sufficiently large pore windows and cages and the aromatic rings which make them attractive candidates for the separation of substituted aromatics. 33À35 MIL-101(Cr) is built up from a hybrid supertetrahedral building unit formed by terephthalate ligands and trimeric chromium octahedral clusters and offers high surface area, large pore windows (12 Å and 16 Å Â 14.5 Å), mesoporous pores (29À34 Å), and excellent chemical and solvent stability.…”

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confidence: 99%

Metal–Organic Framework MIL-101(Cr) for High-Performance Liquid Chromatographic Separation of Substituted Aromatics

2011

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The diverse structures and pore topologies, accessible cages and tunnels, and high surface areas make metal-organic frameworks attractive as novel media in separation sciences. Here we report the slurry-packed MIL-101(Cr) column for high-performance liquid chromatographic separation of substituted aromatics. The MIL-101(Cr) packed column (5 cm long × 4.6 mm i.d.) offered high-resolution separation of ethylbenzene (EB) and xylene, dichlorobenzene and chlorotoluene isomers, and EB and styrene. The typical impurities of toluene and o-xylene in EB and styrene mixtures were also efficiently separated on the MIL-101(Cr) packed column. The column efficiencies for EB, m-dichlorobenzene, and m-chlorotoluene are 20000, 13000, and 10000 plates m(-1), respectively. The relative standard deviation for five replicate separations of the substituted aromatics was 0.2-0.7%, 0.9-2.9%, 0.5-2.1%, and 0.6-2.7% for the retention time, peak area, peak height, and half peak width, respectively. The MIL-101(Cr) offered high affinity for the ortho-isomer, allowing fast and selective separation of the ortho-isomer from the other isomers within 3 min using dichloromethane as the mobile phase. The effects of the mobile phase composition, injected sample mass, and temperature were investigated. The separation of xylene, dichlorobenzene, and chlorotoluene on MIL-101(Cr) was controlled by entropy change, while the separation of EB and styrene on MIL-101(Cr) was governed by enthalpy change.

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Silica–MOF Composites as a Stationary Phase in Liquid Chromatography

Cited by 127 publications

References 27 publications

Metal–organic framework composites: from fundamentals to applications

Metal–organic framework composites: from fundamentals to applications

Surface etching of HKUST-1 promoted via supramolecular interactions for chromatography

Metal–Organic Framework MIL-101(Cr) for High-Performance Liquid Chromatographic Separation of Substituted Aromatics

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