Silica Microspheres with Fibrous Shells: Synthesis and Application in HPLC

Abstract

Monodispersed silica spheres with solid core and fibrous shell were successfully synthesized using a biphase reaction. Both the thickness and the pore size of the fibrous shell could be finely tuned by changing the stirring rate during synthesis. When stirring was adjusted from 0 to 800 rpm, the thickness of the shell could be tuned from 13 to 67 nm and the pore size from 5 to 16 nm. By continuously adjusting the stirring rate, fibrous shells with hierarchical pore structure ranged from 10 to 28 nm and thickness up to 200 nm could be obtained in one pot. We demonstrate that fibrous shells with controllable thickness and pore size could be coated on silica cores with diameters from 0.5 to 3 μm while maintaining the monodispersity of the particles. As a result of the unique fibrous structure, the BET surface area could reach ∼233 m(2) g(-1) even though the shell thickness was less than 150 nm. The core-shell particles were modified with C18, packed, and then used in high-performance liquid chromatography (HPLC) separation, showing separation performance as high as 2.25 × 10(5) plates m(-1) for naphthalene and back pressure as low as 5.8 MPa. These silica microspheres with fibrous shells are expected to have great potential for practical applications in HPLC.

Improving the size uniformity of dendritic fibrous nano-silica by a facile one-pot rotating hydrothermal approach

“…32,34 These approaches based on different reaction instruments were able to prepare KCC-1 effectively, whereas evident non-uniformity issue of nanosphere sizes has not been resolved yet. Fortunately, non-uniform size with large differences does not inuence KCC-1 applications like catalysis, 32,33 cancer and tumour therapy, 35,36 gene and protein delivery, 37 water treatment, 38,39 chromatography, 40,41 dye-sensitized solar cell and supercapacitor, 42,43 etc. For this reason, only limited attentions have been paid and few investigations have been conducted to ameliorate KCC-1 size uniformity.…”

Dendritic Fibrous Nanosilica for Catalysis, Energy Harvesting, Carbon Dioxide Mitigation, Drug Delivery, and Sensing

“…Owing to the fibrous nature of DFNS, it can be used as a stationary phase in chromatography. Not exactly DFNS, but solid silica spheres with DFNS‐like fibrous shells (Figure ) were used in high‐performance liquid chromatography (HPLC) . The authors were able to tune the shell thickness from 13 to 67 nm.…”

Core–shell microspheres with porous nanostructured shells for liquid chromatography

“…The structure of core–shell silica particles with solid core and nanofibrous shell. Reprinted with permission from …”