Silica-lipid hybrid (SLH) microcapsules: A novel oral delivery system for poorly soluble drugs

Preparation of polylactide-co-glycolide nanoparticles incorporating celecoxib and their antitumor activity against brain tumor cells

“…19 Tan et al reported on a silica-lipid hybrid incorporating celecoxib microcapsules for oral drug delivery. 29 They described similar results for X-ray powder diffraction, ie, the microcapsules incorporating celecoxib showed a broad spectrum, while the drug itself showed sharp intrinsic crystalline peaks.…”

“…They reported that silicalipid hybrid microcapsules were effective for enhancing drug dissolution properties and increasing the drug half-life in plasma. 29 Thakkar et al reported that celecoxib incorporated into albumin microspheres was released over about 1 week. 23 Furthermore, they also observed an initial burst effect for 12 hours, ie, more than 50% (w/w) of the drug was released in the first 12 hours.…”

Ordered nanoporous silica as carriers for improved delivery of water insoluble drugs: a comparative study between three dimensional and two dimensional macroporous silica

“…[10][11][12][13][14] Porous silicate is a porous material that has been commonly used as a pharmaceutical excipient. Several grades of porous silicate having different characteristics such as particle size, pore size, and specific surface area are commercially available and have been widely employed to encapsulate poorly soluble drugs, such as Aerosil [15][16][17][18] Since the discovery of mesoporous (2 nm ,pore size ,50 nm) silica materials in the 1990s, the synthesis and application of mesoporous silica have received substantial attention due to their high surface area, well defined and tunable pore size, uniform porous structure, and easily modified surface. [19][20][21][22] Among these mesoporous silica, Mobil Composition of Matter (MCM)-41 and Santa Barbara Amorphous (SBA)-15 , with a two dimensionally ordered hexagonal arrangement of cylindrical pores of uniform size (typically 2-10 nm) disposed parallel to each other ( Figure 1A), are probably the most investigated materials.…”

“…A sample corresponding to 25 mg IMC was introduced onto the surface of dissolution medium at time zero. Aliquots (5 mL) of the dissolution medium were withdrawn and passed through a 0.45 µm membrane filter at appropriate intervals (5,10,15,20,30,45, and 60 minutes). In addition, an equal volume of fresh dissolution medium was immediately added to keep the volume constant.…”

Self-emulsifying therapeutic system: a potential approach for delivery of lipophilic drugs

“…The thermotropic stability of SMEFs and their high drug loading efficiency make them a promising system for low aqueous soluble drugs (Jannin et al, 2007). SMEFs are usually placed in soft gelatin capsules, but can also be transformed into granules, pellets, powders for dry filled capsules or tablet preparations (Nazzal, Khan, 2006;Serratoni, Newton, 2007;Abdalla et al, 2008;Tan et al, 2009). The commercial success of the SMEF, Neoral ® drew greater attention to the development of SMEFs.…”