Silica immobilised palladium phosphine complexes as recyclable, regioselective catalysts for the allylic alkylation

Phosphine-functionalized dendrimers for transition-metal catalysis

“…A widely studied approach to facilitate catalyst-product separation is the attachment of homogeneous catalysts to dendritic [11][12][13][14][15][16], or hybrid supports [17][18][19][20]. We have studied several approaches to obtain recyclable catalyst systems, including immobilization on various supports and two-phase catalysis [21][22][23][24][25][26][27][28][29][30]. As an important alternative we have been investigating the immobilization of catalysts to dendritic support.…”

An efficient heterogenized palladium catalyst for N-alkylation of amines and α-alkylation of ketones using alcohols

“…Under these pre-optimized conditions acetophenone gave 1,3diphenylpropan-1-one (26) in 83% yield, while 98% and 96% yields were achieved with 4-methyl (27) and penta-methyl (28) substituted acetophenones respectively, when benzyl alcohol was used as the alkylating agent. Unprotected hydroxy group was tolerated and the corresponding alkylated product 29 was obtained in 81% yield.…”

Heterogeneous Supported Palladium Catalysts for Liquid‐Phase Allylation of Nucleophiles

“…The first catalytic allylation reaction using a silica-based material was carried out by Sandee and co-workers in 2001. [46] They used palladium complexes coordinated by trialkoxysilanefunctionalized phosphine ligands decorated on MCM-41. This was used in the allylic alkylation of 3-phenyl-prop-2-enyl trifluoroacetate using sodium diethyl 2-methylmalonate as the nucleophile, which gave both linear (1-substitution without isomerization) and branched products (3-substitution with isomerization of the allylic portion) (Scheme 11).…”

“…Silica-supported Pd complex with phosphine ligands for allylic substitution. [46] Scheme 12. PCNS-catalyzed tandem allylic alkylation and Pauson-Khand reaction.…”