Silica Hydrogels as a Basis of Novel Soft Dosage Forms and Cosmetic Compositions

Dolinina, Ekaterina S.; Parfenyuk, Elena V.

doi:10.1134/s0036023622030068

Cited by 7 publications

(2 citation statements)

References 30 publications

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“…The two-step sol-gel synthesis of the hydrogel composites and pure silica hydrogels has been described in detail in [18]. The hydrogel materials were prepared using HCl concentrations of 0.125M, 0.25M and 0.50M and the drug loadings of 3.9-4.6 mg/g (low drug loading (L)) and 8.5-9.6 mg/g (high drug loading (H)), so the pure silica hydrogels and the hydrogel composites with α-lipoic acid (LA) were designated as HG1, HG2, HG3 and LA-HG1(L), LA-HG1(H), LA-HG2(L), LA0HG2(H), LA-HG3(L) and LA-HG3(H), respectively.…”

Section: Methodsmentioning

confidence: 99%

Deformation Properties of Hydrogel Compositesof Α-Lipoic Acid With Colloid Silica

2022

Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol.

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Hydrogels are widely used as the basis of soft drug formulations and cosmetic compositions (ointments, creams, gels, masks, dermal fillers, etc.). Deformation properties of these products are very important from the point of view of the convenience and safety of their application, as well as optimization of their production process. In this work, inorganic silica hydrogels are considered as a promising basis for the development of new soft drug formulations and products for cosmetology. The hydrogel composites of colloid silica with α-lipoic acid which is a well-known powerful anti-oxidant used for treatment of various skin diseases were synthesized. Besides, the drug has a reju-venating effect on the skin. Taking into account the indicated potential application of the hydrogels and the methods of their administration (transdermal, injection), the hydrogels had a pH of 6.6-7.4. Pure silica hydrogels and their composites with α-lipoic acid were synthesized by a two-step sol-gel method. Using the method of optical microscopy, it was shown that they have a highly po-rous surface. The deformation properties of the synthesized hydrogels under compression, tension, and shear were determined. It is shown that the synthesized hydrogels have a certain elasticity under axial compression, thixotropy and exhibit pseudoplasticity. The effects ofthe synthesis con-ditions (concentration of the catalyst for silica sol formation, the amount of the introduced drug) on the deformation properties of the composites have been established. The effects were explained in terms of the influence of these factors on the strength of the three-dimensional silica framework of the hydrogel materials. The discovered deformation properties of silica hydrogels make them promising for the development of new soft drug formulations for topical application.

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Section: Methodsmentioning

confidence: 99%

Deformation Properties of Hydrogel Compositesof Α-Lipoic Acid With Colloid Silica

2022

Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol.

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“…In this work, silica hydrogels are considered to be a promising platform for development of new HA soft formulations and cosmetic compositions. In our previous work, using small drug molecules as an example, we have shown that silica hydrogels are a promising platform for the development of delivery systems for topical and injectable administration [ 38 , 39 ]. In the present work, the large and more complex molecules of hyaluronic acid were embedded in silica hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Silica Hydrogels as Platform for Delivery of Hyaluronic Acid

Parfenyuk

Dolinina

2022

Pharmaceutics

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Hyaluronic acid (HA) is chondroprotective and anti-inflammatory drug used clinically for treatment of inflammatory disorders (arthritis, skin diseases, bowel diseases, etc.). In addition, HA is a crucial ingredient in the cosmetic products used to eliminate the unpleasant consequences of inflammatory skin diseases. The main disadvantages that limit its use are its low mechanical properties and its rapid biodegradation. In this paper, silica hydrogels are considered as a promising matrix for HA to improve its properties. The hybrid HA-silica hydrogels were synthesized by the sol–gel method. Morphology of the hydrogels was investigated by optical microscopy and scanning electron microscopy methods. Taking into account their potential applications for topical and injectable delivery, much attention was paid to investigation of deformation properties of the hydrogels under shear, compression, and tension. Their resistance to enzymatic degradation in vitro was estimated. Kinetics and mechanisms of HA release from the hybrid hydrogels in vitro were also studied. It was found that the indicated properties can be controlled by synthesis conditions, HA molecular weight, and its loading in the hydrogels. Silica hydrogels are a prospective platform for the development of new soft formulations and cosmetic compositions of HA with improved pharmacological and consumer properties.

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Organosilicon Material in Combination with Structure-Controlling Agents as a Basis for Immobilization of the Enzyme Glucose Oxidase

Lantsova,

Kamanina,

Rybochkin

et al. 2024

Russ. J. Inorg. Chem.

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Silica Hydrogels as a Basis of Novel Soft Dosage Forms and Cosmetic Compositions

Cited by 7 publications

References 30 publications

Deformation Properties of Hydrogel Compositesof Α-Lipoic Acid With Colloid Silica

Deformation Properties of Hydrogel Compositesof Α-Lipoic Acid With Colloid Silica

Silica Hydrogels as Platform for Delivery of Hyaluronic Acid

Organosilicon Material in Combination with Structure-Controlling Agents as a Basis for Immobilization of the Enzyme Glucose Oxidase

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