Silica hydrogel composites as a platform for soft drug formulations and cosmetic compositions

Parfenyuk, Elena V.; Dolinina, Ekaterina S.

doi:10.1016/j.matchemphys.2022.126160

Cited by 9 publications

(5 citation statements)

References 45 publications

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“…Young’s modulus is a typical characteristic of material stiffness, with a larger Young’s modulus indicating less deformability [ 48 ]. The incorporation of O-CMCh and HTCMCh in CMC-based films led to a lower Young’s modulus, indicating better toughness, superior processability, and wider applicability.…”

Section: Resultsmentioning

confidence: 99%

Effects of Chitosan and Cellulose Derivatives on Sodium Carboxymethyl Cellulose-Based Films: A Study of Rheological Properties of Film-Forming Solutions

Zhang

Liu

et al. 2023

Molecules

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Bio-based packaging materials and efficient drug delivery systems have garnered attention in recent years. Among the soluble cellulose derivatives, carboxymethyl cellulose (CMC) stands out as a promising candidate due to its biocompatibility, biodegradability, and wide resources. However, CMC-based films have limited mechanical properties, which hinders their widespread application. This paper aims to address this issue by exploring the molecular interactions between CMC and various additives with different molecular structures, using the rheological method. The additives include O-carboxymethylated chitosan (O-CMCh), N-2-hydroxypropyl-3-trimethylammonium-O-carboxymethyl chitosan (HTCMCh), hydroxypropyltrimethyl ammonium chloride chitosan (HACC), cellulose nanocrystals (CNC), and cellulose nanofibers (CNF). By investigating the rheological properties of film-forming solutions, we aimed to elucidate the influencing mechanisms of the additives on CMC-based films at the molecular level. Various factors affecting rheological properties, such as molecular structure, additive concentration, and temperature, were examined. The results revealed that the interactions between CMC and the additives were dependent on the charge of the additives. Electrostatic interactions were observed for HACC and HTCMCh, while O-CMCh, CNC, and CNF primarily interacted through hydrogen bonds. Based on these rheological properties, several systems were selected to prepare the films, which exhibited excellent transparency, wettability, mechanical properties, biodegradability, and absence of cytotoxicity. The desirable characteristics of these selected films demonstrated the strong biocompatibility between CMC and chitosan and cellulose derivatives. This study offers insights into the preparation of CMC-based food packaging materials with specific properties.

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Section: Resultsmentioning

confidence: 99%

Effects of Chitosan and Cellulose Derivatives on Sodium Carboxymethyl Cellulose-Based Films: A Study of Rheological Properties of Film-Forming Solutions

Zhang

Liu

et al. 2023

Molecules

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“…Conventional hydrogels are usually recognized as soft and weak materials, and used in limited fields where mechanical properties are not highly concerned, [1–4] such as drug delivery and water absorbent [5–9] . In order to extend the application fields, there are many attempts to toughen hydrogels by the control of network structure and energy‐dissipation mechanism.…”

Section: Introductionmentioning

confidence: 99%

“…Conventional hydrogels are usually recognized as soft and weak materials, and used in limited fields where mechanical properties are not highly concerned, [1][2][3][4] such as drug delivery and water absorbent. [5][6][7][8][9] In order to extend the application fields, there are many attempts to toughen hydrogels by the control of network structure and energy-dissipation mechanism. Noncovalent interactions such as hydrogen bonds, ionic bonds, and hydrophobic interactions are widely employed as energydissipation elements to toughen hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Toughening Hydrogels by Forming Robust Hydrazide‐Transition Metal Coordination Complexes

Zhu

Zuo

et al. 2023

Chemistry A European J

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Energy dissipation based on dynamic fracture of metal ligands is an effective way to toughen hydrogels for specific applications in biomedical and engineering fields. Exploration of new kinds of metal-ligand coordinates with robust bonding strength is crucial for the facile synthesis of tough gels. Here a hydrogel toughening strategy based on the formation of robust coordination complexes between the hydrazide ligands and zinc ions is reported. The resultant hydrogels exhibit high strength and toughness at room temperature. Their mechanical properties show temperature dependence due to the dynamic nature of coordination bonds. In addition, the amine group of hydrazides in the gel matrix provides a reactive site for Schiff's base reaction, enabling surface modification without influence on overall mechanical performances of the gel. The hydrazide ligands are easy to synthesize and can coordinate very well with several transition metals. Such a metal-ligand coordination should be suitable to develop tough soft materials with versatile applications.

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“…Silica particles as eco-friendly inorganic materials are widely utilized in various fields. Especially, due to their nontoxicity, opacity, and poor agglomeration properties, they are frequently used as cosmetic and pharmaceutical materials. − In these applications, the spreadability, hygroscopicity, and afterfeel mainly depend on the size and morphology of those particles, with a typical spherical shape and particle sizes ranging from several hundreds of nanometers to several tens of micrometers. Basically, since pristine silica particles without surface modifications contain several hydroxyl groups on the surface, they are inherently hydrophilic and resistant to oil. , To maximize their usability for multiple functions, superhydrophobic characteristic should be imparted by chemical surface modifications with hydrophobic moieties or by roughness control. , Especially, the functional organic–inorganic hybrid method has been recognized as a promising approach for achieving superhydrophobic or oleophobic surfaces because of its simple preparation, cost-effectiveness, and large-scale applicability. − Compared with other low surface energy materials, fluorinated organic materials are widely utilized to prepare superhydrophobic or oleophobic surfaces because they have several advantages such as chemical resistance, thermal stability, photostability, and good wear resistance. , However, their practical application can be limited by their expensive price, low biocompatibility, and environmental issues related to the ozone shield.…”

Section: Introductionmentioning

confidence: 99%

Controlling Superhydrophobicity and Oleophobicity of Polydimethylsiloxane-Coated Silica Hybrid Particles

et al. 2023

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Hierarchical functional organic–inorganic hybrid particles for versatile control of surface wettability have attracted much attention in a wide range of applications from makeup cosmetics to anti-smudging optoelectronic devices. In this study, superhydrophobic and oleophobic organic–inorganic hybrid particles were prepared by a simple and systematic fabrication strategy using the synergistic combination of commonly available silica particles and polydimethylsiloxanes (PDMSs) with hydrophobic chain ends. Various types of PDMSs with different chain lengths and chemical structures were surface-grafted to silica microparticles through facile physical dispersion and subsequent thermal treatment to form hydrogen bonds or covalent bonds between the inorganic silica and organic PDMS polymers and thus induce a core–shell structure for the hybrid particles, which imparts superhydrophobicity and oleophobicity to the surface of silica particles. The prepared PDMS-coated silica hybrid particles with long PDMS chains exhibited a water contact angle of 151.2° and an oil contact angle of 15.2° due to the rough surface morphology and hydrophobic long-chain effects. Furthermore, the resulting organic–inorganic hybrid particles were thermally stable up to 420 °C. This controlled approach endowed the organic–inorganic hybrid particles with both superhydrophobic and oleophobic surfaces and, therefore, these particles were proven to be suitable for waterproof applications.

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Silica hydrogel composites as a platform for soft drug formulations and cosmetic compositions

Cited by 9 publications

References 45 publications

Effects of Chitosan and Cellulose Derivatives on Sodium Carboxymethyl Cellulose-Based Films: A Study of Rheological Properties of Film-Forming Solutions

Effects of Chitosan and Cellulose Derivatives on Sodium Carboxymethyl Cellulose-Based Films: A Study of Rheological Properties of Film-Forming Solutions

Toughening Hydrogels by Forming Robust Hydrazide‐Transition Metal Coordination Complexes

Controlling Superhydrophobicity and Oleophobicity of Polydimethylsiloxane-Coated Silica Hybrid Particles

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