Silica-grafted DBU-supported NiCl2: a sustainable heterogeneous catalyst for A3 coupling

Green synthesis of 1,4-disubstituted 1,2,3-triazoles: a sustainable approach

“…160 The sorption and reusability properties, along with the high density of Cu-MOFs, 111 present a promising avenue for the systematic catalysis of this reaction, offering enhanced efficiency and durability. 136 The catalyst (Fe 3 O 4 @HKUST-1) was synthesized by Arefi et al by coating Fe 3 O 4 nanoparticles onto Cu-MOF. The copper moiety in the catalyst demonstrates high efficiency in catalyzing the synthesis of 1,4-disubstituted 1,2,3-triazoles, with water serving as an environment-friendly solvent, as shown in Table 6, entry (1).…”

“…135 Pharande et al developed a cellulose-supported Schiff base Cu(II) catalyst, denoted as [(Cell-ThP-Cu(II))], for a one-pot Chan-Lam coupling forwarded by Huisgen 1,3-cycloaddition for the synthesis of various 1-aryl-1,2,3-triazoles using arylboronic acid, sodium azide, and phenyl acetylenes in a green solvent at rt. The outlined Table 4, entry (10) 136 provides an environmentally benign and economically viable approach to the 1,4-disubstituted 1,2,3triazole synthesis. Chen and co-workers developed a highly effective copper/TEMPO catalytic system designed for multiple oxidation and cycloaddition reactions involving acyl-alkyl ketones (alcohols) and organic azides for the synthesis of 4-acyland 4-diketo-1,2,3-triazoles 137 as shown in Table 4, entry (11).…”

Recent advances in Chan–Lam coupling reaction

“…Pharande's research group recently unveiled a pioneering cellulose-based heterogeneous copper catalytic system for the synthesis of 1-aryl-1,2,3-triazoles. 63 This greener one-pot multicomponent synthesis of 1-aryl-1,2,3-triazoles involves consecutive Chan-Lam coupling and Huisgen 1,3-cycloaddition. The sodium azide, phenylboronic acids, and phenyl acetylenes were reacted in the presence of 0.072 mol% of a cellulose-based copper catalyst (Cell-ThP-Cu(II)) in water at room temperature for 6 h (Scheme 60).…”