Silica gel Supported Boric tri-Sulfuric Anhydride (SiO2-BTSA): an Efficient Catalytic System for the Synthesis of Phloroglucide analogs as Antimicrobial Agents
Abstract:An efficient procedure for the synthesis of polyhydroxyl aromatic compounds (phloroglucide analogs) is described. In this procedure a reaction was done between different 4-substituted phenols and 2,6-bis(hydroxymethy) phenols. The reactions proceed in the presence of catalytic amount of silica gel supported boric tri-sulfuric anhydride (SiO2-BTSA) in excellent yields. 16 compounds were synthesized (I1-I16). Chemical structures of all compounds were confirmed by spectroscopic methods. We optimized the chemical … Show more
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