Silica exposure, silicosis, autoimmune diseases, tuberculosis and nontuberculous pulmonary mycobacterial disease

Mizutani, Rafael Futoshi; Lombardi, Elisa Maria Siqueira; Santos, Ubiratan de Paula; Terra-Filho, Mário

doi:10.1183/13993003.congress-2016.pa1171

Cited by 4 publications

(3 citation statements)

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“…The risk of developing tuberculosis infection in silica‐exposed individuals is many times greater than in the general population, although no data are yet available about TB infection in the artificial stone cohort. Non‐tuberculous mycobacterial infection (NTMI) also has a higher prevalence.…”

Section: Associated Diseasesmentioning

confidence: 99%

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Silicosis in artificial stone workers: Spectrum of radiological high‐resolution CT chest findings

Jones¹,

Pasricha²,

Heinze

et al. 2020

J Med Imag Rad Onc

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Summary Silicosis in artificial stone workers has become increasingly recognised in Australia over the last two years, with a large proportion of screened workers showing imaging features of the disease. The spectrum of findings has differed from the classical silicosis previously described, with many features of accelerated disease, including ground‐glass opacities and progressive massive fibrosis. This cohort of patients presents after exposure to a unique product high in silica and other binding agents, and the patterns of disease on imaging in this cohort are not previously described. This article reviews the radiological features seen in different forms of silicosis seen to date in this Australian cohort.

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Section: Associated Diseasesmentioning

confidence: 99%

“…There is emerging evidence that silica exposure may favour the development of certain subtypes of SLE over others . The rate of tuberculous infection in silica‐exposed patients with autoimmune disease has been reported as high as 36%; therefore, TB testing in this subset of patients is recommended.…”

Section: Autoimmune Diseasesmentioning

confidence: 99%

Silicosis in artificial stone workers: Spectrum of radiological high‐resolution CT chest findings

Jones¹,

Pasricha²,

Heinze

et al. 2020

J Med Imag Rad Onc

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“…The time duration of TB following silicosis might be several years. The silica impairs the activity of alveolar macrophages, and severe exposure leads to macrophage apoptosis [8]. In addition, excessive surfactant protein A is associated with higher susceptibility to TB, possibly through the inhibition of the production of reactive nitrogen species by the activated macrophages, leading to the entrance of mycobacteria into the alveolar macrophages without triggering cytotoxicity [9].…”

Section: Contextmentioning

confidence: 99%

Risk factors and control strategies for silicotuberculosis as an occupational disease

Shafiei

Ghasemian

Eslami

et al. 2019

New Microbes and New Infections

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Silicotuberculosis is critical in community settings among workers and employees exposed to silica dust. Older age of entry (>30 years), male sex, infection with human immunodeficiency virus (HIV), exposure duration, smoking, chronic obstructive pulmonary disease, migration, the severity of the silicosis and the intensity of the exposure are potential risk factors. Lack of timely diagnosis and treatment for tuberculosis (TB) may also raise the rate of infection; previous treatment of TB is possibly associated with the development of silicotuberculosis in more than half of patients, increasing with age (>40 years). Identification of risk factors benefits not only the academic research community, but also the workers or employees and policy making. Some strategies can be implemented, such as controlling or reducing exposure to silica dust, ensuring continuity of treatment of TB or extended anti-TB treatment, management of the situation by occupational health professionals, prevention of oscillating migration, providing workers with compensation, training and education in occupational health, improving the quality of life of miners and workers, intensive medical surveillance and TB screening in routine health check ups, and policy making for higher immunity to inhibit inhalation of dust by workers or employees.

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Dust and Microorganisms: Their Interactions and Health Effects

Noda

Morimoto

Mitarai

et al. 2023

Emerging Contaminants and Associated Treatment Technologies

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Silica exposure, silicosis, autoimmune diseases, tuberculosis and nontuberculous pulmonary mycobacterial disease

Cited by 4 publications

References 0 publications

Silicosis in artificial stone workers: Spectrum of radiological high‐resolution CT chest findings

Silicosis in artificial stone workers: Spectrum of radiological high‐resolution CT chest findings

Risk factors and control strategies for silicotuberculosis as an occupational disease

Dust and Microorganisms: Their Interactions and Health Effects

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