Silica Exposure and Effect on Peak Expiratory Flow: Slate Pencil Workers' Study

Tiwari, Rajnarayan R

doi:10.4187/respcare.04903

Cited by 3 publications

(3 citation statements)

References 16 publications

(11 reference statements)

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“…PEFR in detecting obstructive changes in the respiratory tract using spirometer has a good correlation with the FEV1 (Tiwari, 2016). Earlier studies showed range values of 0.5 to 0.9, which were moderate to good correlation coefficients between percent predicted PEF and percent predicted FEV1 (Kelly and Gibson, 1988;Thiadens et al, 1999).…”

Section: Resultsmentioning

confidence: 90%

Effect of Exposure to Airborne Chalk Dust Particles on Students’ Respiratory Function

Azodo,

Olasunkanmi,

Akpan

2020

MJST

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The use and reuse function of chalkboard produces chalk dust particles in the classroom entering into the classroom occupants’ respiratory system through their mouths and nasopharyngeal regions while talking or breathing. The potential impact of dust particles of the respiratory system includes airflow resistance, lung volumes impairment and lung damage. This study measured the expired volume of air from the lungs during a guided maximal expiration to determine the effect of chalk dust particles on the ultimate lung function in the classroom. The sociodemographic characteristics of the participants were assessed using oral interview while the assessment of the anthropometric data and the participants’ lung function indices was done through the use of a stadiometer and digital spirometer, respectively. This study employed a quasiexperimental research design. It involved the exposed (n = 120) and control (n = 120) groups selected from classrooms where chalkboards and marker boards were used, respectively. The results revealed that among the lung functions indices investigated, there were statistical significant differences between the exposed and the control groups in FEV1 (%) (0.002), PEFR (L/s) (0.000), FEF25 (L/s) (0.000) FEF75 (L/s) (0.000), FEF25-75 (L/s) (0.000), FEV1 (%) (0.002) but no significant differences in FEV1 (0.135), FVC (0.493) and FVC (L) (0.506). Therefore, chalk dust particles from chalkboard usage had a negative effect on the respiratory function (lung function indices) in the classrooms.

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Section: Resultsmentioning

confidence: 90%

Effect of Exposure to Airborne Chalk Dust Particles on Students’ Respiratory Function

Azodo,

Olasunkanmi,

Akpan

2020

MJST

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“…Some cross-sectional studies have reported significant reductions in PEF. However, these studies provided no data on the levels of silica exposure [ 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

Pulmonary function and respiratory symptoms in workers exposed to respirable silica dust: A historical cohort study

Sohrabi

Sabet

Yousefinejad

et al. 2022

Heliyon

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“…Persistent inflammation of the alveoli and further pulmonary fibrosis can result in irreversible ventilatory impairment in silicosis [ 32 – 34 ]. FEV1, FVC and PEF are important parameters to evaluate airway obstruction of workers with silica exposure [ 3 , 32 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

The significance of serum S100 calcium-binding protein A4 in silicosis

Zhang

Yuan

et al. 2022

BMC Pulm Med

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Background Silicosis is a chronic occupational pulmonary disease characterized by persistent inflammation and irreversible fibrosis. Considerable evidences now indicate that S100 calcium-binding protein A4 (S100A4) has been associated with fibrotic diseases. However, the role of S100A4 in silicosis is still unclear. Methods In this study, serum levels of S100A4, transforming growth factor-β1 (TGF-β1), connective tissue growth factor (CTGF), interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α) in patients with silicosis (n = 42) and control group (CG, n = 12) were measured by ELISA. S100A4 expression in lung tissues and primary alveolar macrophages (AMs) of mice with and without silicosis was detected by immunohistochemistry (IHC)/real-time PCR. The correlations between S100A4 and cytokines or lung function were assessed by Spearman's rank correlation analyses. Results Compared with CG, the levels of S100A4 were significantly increased in silicosis patients (70.84 (46.22, 102.46) ng/ml vs (49.84 (42.86, 60.02) ng/ml). The secretions of TGF-β1, CTGF, IL-6 and TNF-α in silicosis group were significantly higher than that in control group (p < 0.05). Serum S100A4 levels were positively correlated with TGF-β1 and IL-6, while were negatively correlated with lung function parameters including percentage of predicted forced vital capacity (FVC%pre), maximum vital capacity (Vcmax), deep inspiratory capacity (IC) and peak expiratory flow at 75% of vital capacity (PEF75). In receiver operating characteristic (ROC) analyses, S100A4 > 61.7 ng/ml had 63.4% sensitivity and 83.3% specificity for silicosis, and the area under the curve (AUC) was 0.707. Furthermore, immunostaining of lung tissues showed the accumulation of S100A4-positive cells in the areas of nodules of silicotic mice. The mRNA expression of S100A4 in the lung tissues and AMs of silicotic mice were significantly higher than controls. Conclusion These data suggested that increased S100A4 might contribute to the pathogenesis of silicosis.

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Silica Exposure and Effect on Peak Expiratory Flow: Slate Pencil Workers' Study

Abstract: Higher age, female sex, higher duration of exposure, and respiratory morbidity were found to be important correlates of PEF.

Cited by 3 publications

References 16 publications

Effect of Exposure to Airborne Chalk Dust Particles on Students’ Respiratory Function

Effect of Exposure to Airborne Chalk Dust Particles on Students’ Respiratory Function

Pulmonary function and respiratory symptoms in workers exposed to respirable silica dust: A historical cohort study

The significance of serum S100 calcium-binding protein A4 in silicosis

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