Silica-chitosan nanocomposite mediated pH-sensitive drug delivery

Gaware, Shankar; Rokade, Kasturi A.; Kale, S. N.

doi:10.1016/j.jddst.2018.11.022

Cited by 37 publications

(13 citation statements)

References 25 publications

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“…Nanoshell uses plants in the synthesis of The production of gold, silica and silver nanoparticles and many other nanoparticles, using Geranium extract, Aloe Vera plant extracts, Curcumin, Moringa oleifera, sundried Cinnamomum camphora and Azadiracta indica leaf extract, neem plant extract are already reported [37][38][39]. Synthesis of nanoparticles using bacteria has enlarged comprehensively due to its immense application in various areas like medicinal science [40][41][42][43] ;…”

Section: Degradation Of Mb Dyementioning

confidence: 99%

Green AgNPs Decorated ZnO Nanocomposites for Dye Degradation And Antimicrobial Applications

Jadhav¹,

Shinde²,

Suryawanshi³

et al. 2020

Eng. Sci.

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Nanotechnology is an ablaze branch for the scientists which deals with study of synthesis, characterization and application of nanomaterial. Phytochemicals available as bio-molecules present in Gongura leaves can be used to reduce silver ions into silver nanoparticles in a single step by novel synthetic routes. This biogenic reduction of silver ion to silver metal is quite rapid and can be easily scaled up. ZnO nanoparticles are synthesized using popular hydrothermal route of synthesis. X-ray diffraction pattern of reaction product confirmed the formation of silver and zinc oxide nanoparticles. Optical properties, size and morphology of the ZnO-AgNPs composite has been analyzed using advanced characterization techniques. SEM analysis revels that the bare AgNPs are spherical in shape with particle size ranging from 1.1 to 1.5 µm where as ZnO are in nanorods shape with particle size ranging from 0.3 to 0.4 µm. The synthesized ZnO-Ag composite shows potential biological efficacy against pathogenic microorganisms and are effective in dye degradation. Both of the antimicrobial and antioxidant activity helps in study application of nanoparticles in medical and veterinary sciences. The 5 % AgNPs contain ZnO nanocomposites indicates photo degradation of MB dye(5.0 g/dm 3) with efficiency up to 99.21% within 75 min under UV light irradiation. This study concludes the excellent dye degradation efficiency.

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Section: Degradation Of Mb Dyementioning

confidence: 99%

Green AgNPs Decorated ZnO Nanocomposites for Dye Degradation And Antimicrobial Applications

Jadhav¹,

Shinde²,

Suryawanshi³

et al. 2020

Eng. Sci.

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show abstract

“…This pH sensitivity has been reported for drug delivery applications 40‐42 . Recently, Gaware et al 43 reported the synthesis of curcumin‐loaded pH‐sensitive nanocomposites made of chitosan and silica. They demonstrated a pH‐dependent release of the curcumin.…”

Section: Natural Ph‐responsive Polymersmentioning

confidence: 74%

pH‐sensitive polymers: Classification and some fine potential applications

Ofridam

Tarhini

Lebaz

et al. 2021

Polymers for Advanced Techs

164

111

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Stimuli‐responsive materials in general and pH‐responsive polymers in particular have gained increasing interest during the last two decades. Their unique properties, which arise from their ability to exhibit sharp and reversible changes in response to environmental pH conditions, have made them suitable for various applications such as drug delivery and specific body‐site targeting, sensing and actuation, membrane functionalization, separation techniques, as well as in agriculture and food industry and even chemical industries. In the present review, the focus is on the general characteristics of pH‐responsive polymers in terms of their origin, chemical composition, and preparation. Moreover, some of the important and recent applications are reported and discussed.

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“…Whereas cubosomes were previously sterically stabilized by PEGylated lipids and non-ionic copolymer shells [93,94], more recent research directions tend to combine the advantages of both lipid and polymer derivatives [95][96][97][98][99][100][101][102]. Furthermore, the production of composite cubosomes and cubic phases by associating lipids with macromolecules of pH-dependent structure, including large proteins, polypeptides, polymers, polysaccharides and peptide conjugates [21,97,103,104], can provide a wider range of novel delivery systems [105][106][107][108][109][110][111][112].…”

Section: Perspectives Of Ph-sensitive Cubosomesmentioning

confidence: 99%

Advances in the Design of pH-Sensitive Cubosome Liquid Crystalline Nanocarriers for Drug Delivery Applications

2020

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Nanostructure bicontinuous cubic phase self-assembled materials are receiving expanding applications as biocompatible delivery systems in various therapeutic fields. The functionalization of cubosome, spongosome, hexosome and liposome nanocarriers by pH-sensitive lipids and/or pH-sensitive polymer shells offers new opportunities for oral and topical drug delivery towards a new generation of cancer therapies. The electrochemical behavior of drug compounds may favor pH-triggered drug release as well. Here, we highlight recent investigations, which explore the phase behavior of mixed nonlamellar lipid/fatty acid or phospholipid systems for the design of pH-responsive and mucoadhesive drug delivery systems with sustained-release properties. X-ray diffraction and small-angle X-ray scattering (SAXS) techniques are widely used in the development of innovative delivery assemblies through detailed structural analyses of multiple amphiphilic compositions from the lipid/co-lipid/water phase diagrams. pH-responsive nanoscale materials and nanoparticles are required for challenging therapeutic applications such as oral delivery of therapeutic proteins and peptides as well as of poorly water-soluble substances. Perspective nanomedicine developments with smart cubosome nanocarriers may exploit compositions elaborated to overcome the intestinal obstacles, dual-drug loaded pH-sensitive liquid crystalline architectures aiming at enhanced therapeutic efficacy, as well as composite (lipid/polyelectrolyte) types of mucoadhesive controlled release colloidal cubosomal formulations for the improvement of the drugs’ bioavailability.

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Silica-chitosan nanocomposite mediated pH-sensitive drug delivery

Cited by 37 publications

References 25 publications

Green AgNPs Decorated ZnO Nanocomposites for Dye Degradation And Antimicrobial Applications

Green AgNPs Decorated ZnO Nanocomposites for Dye Degradation And Antimicrobial Applications

pH‐sensitive polymers: Classification and some fine potential applications

Advances in the Design of pH-Sensitive Cubosome Liquid Crystalline Nanocarriers for Drug Delivery Applications

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