Silica-Based and Borate-Based, Titania-Containing Bioactive Coatings Characterization: Critical Strain Energy Release Rate, Residual Stresses, Hardness, and Thermal Expansion

Rodriguez, Omar; Matinmanesh, Ali; Phull, Sunjeev; Schemitsch, Emil H.; Zalzal, Paul; Clarkin, Owen; Papini, M.; Towler, Mark R.

doi:10.3390/jfb7040032

Cited by 17 publications

(10 citation statements)

References 53 publications

(73 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The TiO 2 -containing borate-based glasses exhibited significantly superior antibacterial and solubility behaviour in comparison to the silica-based glasses. The effects of partial replacements of SiO 2 in silica-based glasses, or B 2 O 3 in borate-based glasses, by TiO 2 were investigated aiming at adjusting the coefficient of thermal expansion (CTE) of the glass coatings to that of Ti6Al4V substrate [198]. A better fit of CTE values was obtained for borate-based glass.…”

Section: Bioactive Glasses and Glass-ceramicsmentioning

confidence: 99%

Bioactive Glasses and Glass-Ceramics for Healthcare Applications in Bone Regeneration and Tissue Engineering

et al. 2018

View full text Add to dashboard Cite

The discovery of bioactive glasses (BGs) in the late 1960s by Larry Hench et al. was driven by the need for implant materials with an ability to bond to living tissues, which were intended to replace inert metal and plastic implants that were not well tolerated by the body. Among a number of tested compositions, the one that later became designated by the well-known trademark of 45S5 Bioglass® excelled in its ability to bond to bone and soft tissues. Bonding to living tissues was mediated through the formation of an interfacial bone-like hydroxyapatite layer when the bioglass was put in contact with biological fluids in vivo. This feature represented a remarkable milestone, and has inspired many other investigations aiming at further exploring the in vitro and in vivo performances of this and other related BG compositions. This paradigmatic example of a target-oriented research is certainly one of the most valuable contributions that one can learn from Larry Hench. Such a goal-oriented approach needs to be continuously stimulated, aiming at finding out better performing materials to overcome the limitations of the existing ones, including the 45S5 Bioglass®. Its well-known that its main limitations include: (i) the high pH environment that is created by its high sodium content could turn it cytotoxic; (ii) and the poor sintering ability makes the fabrication of porous three-dimensional (3D) scaffolds difficult. All of these relevant features strongly depend on a number of interrelated factors that need to be well compromised. The selected chemical composition strongly determines the glass structure, the biocompatibility, the degradation rate, and the ease of processing (scaffolds fabrication and sintering). This manuscript presents a first general appraisal of the scientific output in the interrelated areas of bioactive glasses and glass-ceramics, scaffolds, implant coatings, and tissue engineering. Then, it gives an overview of the critical issues that need to be considered when developing bioactive glasses for healthcare applications. The aim is to provide knowledge-based tools towards guiding young researchers in the design of new bioactive glass compositions, taking into account the desired functional properties.

show abstract

Section: Bioactive Glasses and Glass-ceramicsmentioning

confidence: 99%

Bioactive Glasses and Glass-Ceramics for Healthcare Applications in Bone Regeneration and Tissue Engineering

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Thus, 10 6 mechanical cycles were performed to represent 2 years of service. 27,28,29 The release of residual stress may have been responsible for the increase in flexural strength for C1 and C2 aged-groups. 30,31 Future studies should address the quantification of leucite crystals through XRD or similar techniques, and the effects of such crystals on the residual stress after repeated pressings.…”

Section: Discussionmentioning

confidence: 99%

Can heat-pressed feldspathic ceramic be submitted to multiple heat-pressing?

et al. 2018

View full text Add to dashboard Cite

The aim of this study was to determine if multiple processing (heat-pressing) of a dental ceramic influences flexural strength, hardness, and microstructure. Ninety bar-shaped specimens (15 mm × 4 mm × 2 mm) of a pressed ceramic (Vita PM9) were fabricated and randomly divided into 6 groups (n = 15) according to the factors "number of pressings" (C1, C2, and C3, fired 1, 2, and 3 times, respectively) and "mechanical cycling" (M). Half of the specimens were mechanically cycled (10 6 cycles, 45 N, 3.4 Hz, in water) and all specimens were tested for 3-point bending (0.5 mm/min, load 1000 kgf) and Vickers hardness (19.6 N for 20 s). X-ray diffraction was used to characterize the phases and scanning electron microscopy to characterize the microstructure. The flexural strength data was statistically analyzed with Weibull analysis, ANOVA, and Tukey test. Hardness data was evaluated by 2-way ANOVA and Fisher test. All tests were performed with a significance level of 0.05. Two-way ANOVA revealed that neither "number of pressings" (p=0.085) or "mechanical cycling" (0.055) significantly affected flexural strength. But Weibull analysis showed significant difference for Weibull moduli and characteristic strength between groups. For hardness, a statistical difference was seen for the interaction "Number of pressings * Mechanical cycling", (p = 0.016). Hardness decreased in the following order: C1 (775±17.2), CM3 (751±101), CM2 (735±45), C3 (701±82), CM1 (671±82), and C2 (663±92). Fewer defects were observed with an increased number of firings. Therefore, the possibility of recycling PM9 ceramic does not interfere in the evaluated mechanical properties and improves microstructure.

show abstract

“…Silica-based and borate-based glasses ( Table 1 ) in this study were previously synthesized, and characterized structurally and mechanically as bulk and coating material [ 45 , 46 ]. TiO 2 was added at the expense of SiO 2 for the SRT series and at the expense of B 2 O 3 for the BRT series.…”

Section: Methodsmentioning

confidence: 99%

Titanium addition influences antibacterial activity of bioactive glass coatings on metallic implants

Rodriguez

Stone

Schemitsch

et al. 2017

Heliyon

Self Cite

View full text Add to dashboard Cite

In an attempt to combat the possibility of bacterial infection and insufficient bone growth around metallic, surgical implants, bioactive glasses may be employed as coatings. In this work, silica-based and borate-based glass series were synthesized for this purpose and subsequently characterized in terms of antibacterial behavior, solubility and cytotoxicity. Borate-based glasses were found to exhibit significantly superior antibacterial properties and increased solubility compared to their silica-based counterparts, with BRT0 and BRT3 (borate-based glasses with 0 and 15 mol% of titanium dioxide incorporated, respectively) outperforming the remainder of the glasses, both borate and silicate based, in these respects. Atomic Absorption Spectroscopy confirmed the release of zinc ions (Zn2+), which has been linked to the antibacterial abilities of glasses SRT0, BRT0 and BRT3, with inhibition effectively achieved at concentrations lower than 0.7 ppm. In vitro cytotoxicity studies using MC3T3-E1 osteoblasts confirmed that cell proliferation was affected by all glasses in this study, with decreased proliferation attributed to a faster release of sodium ions over calcium ions in both glass series, factor known to slow cell proliferation in vitro.

show abstract

Silica-Based and Borate-Based, Titania-Containing Bioactive Coatings Characterization: Critical Strain Energy Release Rate, Residual Stresses, Hardness, and Thermal Expansion

Cited by 17 publications

References 53 publications

Bioactive Glasses and Glass-Ceramics for Healthcare Applications in Bone Regeneration and Tissue Engineering

Bioactive Glasses and Glass-Ceramics for Healthcare Applications in Bone Regeneration and Tissue Engineering

Can heat-pressed feldspathic ceramic be submitted to multiple heat-pressing?

Titanium addition influences antibacterial activity of bioactive glass coatings on metallic implants

Contact Info

Product

Resources

About