1976
DOI: 10.1007/bf00205457
|View full text |Cite
|
Sign up to set email alerts
|

Silica abrogation of mycobacterial adjuvant contact suppression of tumor growth in rats and athymic mice

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

2
9
2

Year Published

1976
1976
1986
1986

Publication Types

Select...
10

Relationship

3
7

Authors

Journals

citations
Cited by 37 publications
(13 citation statements)
references
References 10 publications
2
9
2
Order By: Relevance
“…Antitumor resistance of rats pretreated with adjuvants and then given silica or carrageenan was frequently even lower than that in untreated controls, i.e., was similar to that in rats given silica or carrageenan alone. Since the present work was completed, similar observations have been reported by Hopper et al (18).…”
Section: Effects Of C Parvum And/or Bcg and Of Silica Particles And/supporting
confidence: 90%
“…Antitumor resistance of rats pretreated with adjuvants and then given silica or carrageenan was frequently even lower than that in untreated controls, i.e., was similar to that in rats given silica or carrageenan alone. Since the present work was completed, similar observations have been reported by Hopper et al (18).…”
Section: Effects Of C Parvum And/or Bcg and Of Silica Particles And/supporting
confidence: 90%
“…In previous work, growth of rat tumour xenografts was similarly controlled by admixture with BCG or C. parvum (Pimm & Baldwin, 1975, although the suippression in athymic mice was in accordance with that seen in syngeneic recipients, so that carcinogen-induced sarcomas and hepatomas were readily controlled, while only slight suppression (Chassoux & Salomon, 1975;Hopper et al, 1976;Moore & Nisbet, 1978;Keller, 1977). The indication from the present work is that locally activated host responses can similarly control growth of human malignant cells in an in vivo environment.…”
Section: Discussionmentioning
confidence: 67%
“…It has been shown that abrogation of the host leucocyte response by using silica improved the transplantation rate of rat mammary tumours into nude mice after (Hopper et al, 1976). We therefore injected 25 mg of silica particles ( < 5pm particle size) suspended in normal saline i.p.…”
Section: Methodsmentioning
confidence: 99%