Silica abrogation of mycobacterial adjuvant contact suppression of tumor growth in rats and athymic mice

Hopper, D G; Pimm, M. V.; Baldwin, Robert

doi:10.1007/bf00205457

Cited by 37 publications

(13 citation statements)

References 10 publications

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“…Antitumor resistance of rats pretreated with adjuvants and then given silica or carrageenan was frequently even lower than that in untreated controls, i.e., was similar to that in rats given silica or carrageenan alone. Since the present work was completed, similar observations have been reported by Hopper et al (18).…”

Section: Effects Of C Parvum And/or Bcg and Of Silica Particles And/supporting

confidence: 90%

Abrogation of Antitumor Effects of Corynebacterium parvum and BeG by Antimacrophage Agents: Brief Communication 2

Keller¹

1977

JNCI: Journal of the National Cancer Institute

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Section: Effects Of C Parvum And/or Bcg and Of Silica Particles And/supporting

confidence: 90%

Abrogation of Antitumor Effects of Corynebacterium parvum and BeG by Antimacrophage Agents: Brief Communication 2

Keller¹

1977

JNCI: Journal of the National Cancer Institute

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“…In previous work, growth of rat tumour xenografts was similarly controlled by admixture with BCG or C. parvum (Pimm & Baldwin, 1975, although the suippression in athymic mice was in accordance with that seen in syngeneic recipients, so that carcinogen-induced sarcomas and hepatomas were readily controlled, while only slight suppression (Chassoux & Salomon, 1975;Hopper et al, 1976;Moore & Nisbet, 1978;Keller, 1977). The indication from the present work is that locally activated host responses can similarly control growth of human malignant cells in an in vivo environment.…”

Section: Discussionmentioning

confidence: 67%

BCG treatment of human tumour xenografts in athymic nude mice

Pimm¹,

Baldwin²

1978

Br J Cancer

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Summary.-Xenografts of 3 human malignant cell lines in congenitally athymic nude mice have been examined for susceptibility to BCG. Growth of all 3 tumours, a bladder carcinoma, a melanoma and a colon carcinoma, was suppressed when cells were injected in admixture with BCG. Distant injection of BCG was ineffective. Mice with progressive growths had no detectable anti-human antibody, and rejection of cells and BCG failed to confer protection against subsequent tumour challenge. These studies indicate that human malignant cells are susceptible to local BCGactivated host responses, and that athymic mouse xenografts may be a useful model for assessing the response of human tumours to such agents.

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“…It has been shown that abrogation of the host leucocyte response by using silica improved the transplantation rate of rat mammary tumours into nude mice after (Hopper et al, 1976). We therefore injected 25 mg of silica particles ( < 5pm particle size) suspended in normal saline i.p.…”

Section: Methodsmentioning

confidence: 99%

Human breast-cancer xenografts in immune-suppressed mice

Bailey¹,

Gazet²,

Peckham³

1980

Br J Cancer

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Summary.-Eight serially transplantable human breast-cancer xenograft lines have been established in immune-suppressed mice. Specimens from 102 primary and secondary lesions obtained at surgery from 80 patients were implanted into mice immune-suppressed by thymectomy and whole-body irradiation. A number of variations of implantation site, transplantation technique, method of immune suppression and hormonal manipulation of the host were tried in an attempt to increase the take rate, but without success. The 8 lines established have been serially transplanted into further immune-suppressed mice for at least 2 passages, and appear to maintain characteristic human histopathology, chromosome number and tumour-marker production. None of the tumours show hormone sensitivity. The poor take rate may be a reflection of the biological nature of breast cancer rather than a failure of the immune-deprivation technique, as many other human tumours grow well as xenografts in this system.

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Silica abrogation of mycobacterial adjuvant contact suppression of tumor growth in rats and athymic mice

Cited by 37 publications

References 10 publications

Abrogation of Antitumor Effects of Corynebacterium parvum and BeG by Antimacrophage Agents: Brief Communication 2

Abrogation of Antitumor Effects of Corynebacterium parvum and BeG by Antimacrophage Agents: Brief Communication 2

BCG treatment of human tumour xenografts in athymic nude mice

Human breast-cancer xenografts in immune-suppressed mice

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