Silibinin reverses epithelial-to-mesenchymal transition in metastatic prostate cancer cells by targeting transcription factors

Wu, Kaijie; Zeng, Jin; Li, Lei; Fan, Jinhai; Zhang, Dong; Xue, Yan; Zhu, Guodong; Yang, Lin; Wang, Xinyang; He, Dalin

doi:10.3892/or_00000794

Cited by 19 publications

(1 citation statement)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Silibinin often inhibits PC cells' ability to switch beyond epithelial toward the mesenchymal state. This would be accomplished by inhibiting the NF-κB pathway, which ultimately results in this downregulation of the transcriptional regulators ZEB1 and SLUG, together with vimentin as well as MMP2 (Wu et al, 2010). The activities of silibinin include antiproliferative, proapoptotic, as well as antiangiogenic properties.…”

Section: Effects On Angiogenesis Metastasis and Hypoxia-inducible Factormentioning

confidence: 99%

The efficacy of natural bioactive compounds against prostate cancer: Molecular targets and synergistic activities

Mia,

Dey,

Sakib

et al. 2023

Phytotherapy Research

View full text Add to dashboard Cite

Globally, prostate cancer (PCa) is regarded as a challenging health issue, and the number of PCa patients continues to rise despite the availability of effective treatments in recent decades. The current therapy with chemotherapeutic drugs has been largely ineffective due to multidrug resistance and the conventional treatment has restricted drug accessibility to malignant tissues, necessitating a higher dosage resulting in increased cytotoxicity. Plant‐derived bioactive compounds have recently attracted a great deal of attention in the field of PCa treatment due to their potent effects on several molecular targets and synergistic effects with anti‐PCa drugs. This review emphasizes the molecular mechanism of phytochemicals on PCa cells, the synergistic effects of compound‐drug interactions, and stem cell targeting for PCa treatment. Some potential compounds, such as curcumin, phenethyl‐isothiocyanate, fisetin, baicalein, berberine, lutein, and many others, exert an anti‐PCa effect via inhibiting proliferation, metastasis, cell cycle progression, and normal apoptosis pathways. In addition, multiple studies have demonstrated that the isolated natural compounds: d‐limonene, paeonol, lanreotide, artesunate, and bicalutamide have potential synergistic effects. Further, a significant number of natural compounds effectively target PCa stem cells. However, further high‐quality studies are needed to firmly establish the clinical efficacy of these phytochemicals against PCa.

show abstract

Section: Effects On Angiogenesis Metastasis and Hypoxia-inducible Factormentioning

confidence: 99%

The efficacy of natural bioactive compounds against prostate cancer: Molecular targets and synergistic activities

Mia,

Dey,

Sakib

et al. 2023

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

Plumbagin induces ROS-mediated apoptosis and cell cycle arrest and inhibits EMT in human cervical carcinoma cells

et al. 2018

View full text Add to dashboard Cite

show abstract

Bioactive Natural Products against Prostate Cancer: Mechanism of Action and Autophagic/Apoptotic Molecular Pathways

Gioti

Τέντα

2015

Planta Med

View full text Add to dashboard Cite

Introduction !Prostate cancer (PCa) is one of the most common malignancies in men and a leading cause of death worldwide for men. Taking into consideration that chemotherapy has severe side effects and usually a poor outcome, there is an intensive need for the development of safer and more effective agents. Since plants have been used by traditional medicine for the treatment of various diseases, in the last decades, many natural products have been isolated from plants and tested for their tumor selectivity and cytotoxic efficacy. Several of these naturally occurring compounds have been found to inhibit PCa growth and metastasis and are thus a promising approach for the treatment of this malignancy. Laboratory studies in different in vitro and in vivo systems have shown that these natural products modulate cellular processes, exhibit chemopreventive and/or chemotherapeutic effects, and induce apoptosis and autophagy. Accordingly, the antiproliferative and autophagic effects of nontoxic dietary agents could be of additional significance for the prevention, control, and management of PCa, specifically for the advanced and androgen-independent stage of the malignancy [1][2][3]. As there is increasing data on how natural compounds interfere with diverse molecular pathways in cancer cells, this review discusses the mechanism of action of bioactive natural products in the field of PCa and emphasizes the implicated molecular pathways of apoptosis and autophagy as important processes that control cellular homeostasis and that have been highlighted as promising targets for novel cancer therapies.Apigenin ! Apigenin (4′,5,7-trihydroxyflavone) is a flavone found in plants of the Asteraceae family, such as Anthemis sp., and many fruits and vegetables [4]. Apigenin has been tested in various types of cancer cell lines (breast, colon, liver, lung) showing promising results [5]. In prostate cancer in particular, apigenin administered in various concentrations (1-20 μΜ) for 24, 48, and 72 h not only causes G1 cell cycle arrest both in androgen-dependent (LNCaP) and -independent (DU145 and PC-3) PC cell lines through the decreased expression of cyclins D1, D2, and E, but also induces apoptosis through a shift in the Bax/Bcl-2 ratio [6,7]. Further studies in PC-3 cells have also demonstrated that apigenin (5-40 μΜ), delivered for 24 h, suppresses cell proliferation and induces apoptosis by inhibiting IGF-IGF-IR signaling and inactivating the PI3k/Akt pathway [8]. Apigenin Abstract ! Prostate cancer is one of the leading causes of death worldwide for men. There is increasing evidence that diet and lifestyle play a crucial role in prostate cancer biology and tumorigenesis. Due to the fact that conventional chemotherapy is not adequately effective against prostate cancer and has severe side effects, numerous in vitro studies have been conducted in order to identify the potent cytotoxic or chemopreventive activity of naturally occurring compounds and their respective molecular mechanisms of action. In this context, many natural compo...

show abstract

Silibinin reverses epithelial-to-mesenchymal transition in metastatic prostate cancer cells by targeting transcription factors

Cited by 19 publications

References 35 publications

The efficacy of natural bioactive compounds against prostate cancer: Molecular targets and synergistic activities

The efficacy of natural bioactive compounds against prostate cancer: Molecular targets and synergistic activities

Plumbagin induces ROS-mediated apoptosis and cell cycle arrest and inhibits EMT in human cervical carcinoma cells

Bioactive Natural Products against Prostate Cancer: Mechanism of Action and Autophagic/Apoptotic Molecular Pathways

Contact Info

Product

Resources

About