Abstract:The present work was aimed to evaluate the effect of valproic acid(VPA),Silibinin (SIM)+VPA on Ti rods osseointegration in ovariectomized rats and further investigation of the possible mechanism. The MC3T3-E1 cells were co-cultured with VPA,SIM +VPA and induced to osteogenesis, and the cell viability,mineralization ability were observed by MTT and ALP staining,Alizarin Red staining and Western blotting. Twelve weeks after bilateral ovariectomy, all animals were randomly divided into four groups: group OVX and … Show more
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