Silent spread of dengue and dengue haemorrhagic fever to 
Coimbatore and Erode districts in Tamil Nadu, India, 1998: 
need for effective surveillance to monitor and control the 
disease

Singh, Jagvir; Balakrishnan, N.; Bhardwaj, M; Amuthadevi, P.; George, E. G.; Subramani, K.; Soundararajan, K.; Appavoo, N. C.; Jain, Deepali; Ichhpujani, Rattan; Bhatia, Rajesh; Sokhey, J

doi:10.1017/s0950268899003866

Cited by 21 publications

(12 citation statements)

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“…In this study, we confirmed the subclinical DEN infections and demonstrated that patients with secondary DEN-2 infections tend to have a higher rate of DHF. This kind of subclinical transmission of DEN infections has also been reported from India (Singh et al, 2000). This suggests that heterotypic secondary DEN infections associated with a higher rate of DHF development may be more frequent in Taiwan and possibly in other Asian countries.…”

Section: Discussionsupporting

confidence: 69%

Implications of previous subclinical dengue infection but not virus load in dengue hemorrhagic fever

Yeh

Chen

Wang

et al. 2006

FEMS Immunology &Amp; Medical Microbiology

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In a study comparing the virus load and immune reaction between patients with primary and secondary dengue-2 (DEN-2) infections in a hospital-based analysis, we found that 40.7% (55/135) of the 135 patients had secondary DEN-2 infection following a DEN-2 outbreak in southern Taiwan. Most of the secondary infections had subclinical primary dengue infections (78.2%; 43/55). Patients with secondary DEN-2 infections had lower platelet counts, and blood interferon-a and virus load, but significantly higher interleukin-10 (P = 0.030) and anti-DEN-1 neutralization titers (P = 0.013) than those with primary infection. Patients with secondary DEN-2 infection also had a higher rate of dengue hemorrhagic fever (DHF) (61.7% vs. 36.3%). A previous subclinical dengue infection is involved in the secondary DEN-2 infection associated with altered immune reaction and higher DHF rate, but lower blood virus load.

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Section: Discussionsupporting

confidence: 69%

Implications of previous subclinical dengue infection but not virus load in dengue hemorrhagic fever

Yeh

Chen

Wang

et al. 2006

FEMS Immunology &Amp; Medical Microbiology

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“…7 Most dengue infections in humans are asymptomatic and silent circulation of dengue virus among human and mosqui-toes has been reported during interepidemic periods of the disease. 8,9 Therefore, understanding the dynamics of dengue transmission before outbreaks may offer a window of opportunity for prevention. Surveillance of dengue transmission in Colombia is made based in a passive system through the notification of disease cases in humans and the survey for variations in Aedes larvae indexes.…”

Section: Introductionmentioning

confidence: 99%

Human and Mosquito Infections by Dengue Viruses During and After Epidemics in a Dengue–endemic Region of Colombia

Paz¹,

Barreto²,

Arias³

et al. 2006

The American Journal of Tropical Medicine and Hygiene

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We conducted a study in a dengue-endemic area of Colombia to evaluate the dynamics of transmission of dengue viruses during and after epidemics. Information was simultaneously gathered about occurrence of infection in humans and mosquitoes every three months in four cities with endemic transmission. Viral isolation was confirmed in 6.7% of the persons and most were asymptomatic. Adult mosquito and larvae house indexes were not found associated with increased burden of disease. The only entomologic indicator related to dengue infection in humans was the pooled infection rate of mosquitoes. Aedes aegypti infection rates showed significant differences between the epidemic (10.68, 95% confidence interval [CI] = 7.04-15.62) and after epidemic periods of the study (6.15, 95% CI = 3.46-10.19). In addition, Ae. albopictus were also infected with dengue viruses. Increases in mosquito infection rates were associated with increases in human infection rates in the following trimester.

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“…Subsequently, with the introduction of piped water supply, dengue made incursions to rural areas of south India and outbreaks have been reported (Abdul Kader et al . 1997; Singh et al . 2000).…”

Section: Introductionmentioning

confidence: 99%

“…During that time there was little storage of water in villages and therefore Aedes species were scarce (Reuben 1971a,b) and dengue was absent. Subsequently, with the introduction of piped water supply, dengue made incursions to rural areas of south India and outbreaks have been reported (Abdul Kader et al 1997;Singh et al 2000). In rural areas of India, the role of Ae.…”

Section: Introductionmentioning

confidence: 99%

Dengue vector prevalence and virus infection in a rural area in south India

Tewari

Thenmozhi

Katholi

et al. 2004

Tropical Med Int Health

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SummaryWe conducted a 2-year (1997)(1998)(1999) longitudinal, entomological and virological study in three dengue endemic villages in Vellore district, Tamil Nadu, to understand the dynamics of dengue transmission. Aedes aegypti (Linn.), Ae. albopictus (Skuse) and Ae. vittatus (Bigot) were the prevalent vector species. Aedes aegypti was breeding throughout the year with a Breteau index ranging from 9.05 to 45.49. Aedes albopictus and Ae. vittatus were prevalent mainly in the rainy season. Small water holding containers (cemented tanks/cisterns) were the perennial breeding source of Ae. aegypti, and its abundance was significantly higher in semi-urbanized central areas than the peripheral areas of the villages. From 271 pools (4016 specimens) of adult females, eight dengue virus (DENV) isolates were obtained of which seven were from Ae. aegypti and one from Ae. albopictus. This is the first report of DENV isolation from Ae. albopictus in rural India. Infection rates in the two species were comparable. However, due to higher and perennial prevalence, Ae. aegypti is considered as primary vector with Ae. albopictus playing a secondary role. Despite circulation of all four serotypes (DENV 1-4) detected mainly during the transmission season, the high anthropophilic index of the vectors and their abundance, no human dengue case was reported, suggesting silent dengue transmission.

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Silent spread of dengue and dengue haemorrhagic fever to Coimbatore and Erode districts in Tamil Nadu, India, 1998: need for effective surveillance to monitor and control the disease

Cited by 21 publications

References 0 publications

Implications of previous subclinical dengue infection but not virus load in dengue hemorrhagic fever

Implications of previous subclinical dengue infection but not virus load in dengue hemorrhagic fever

Human and Mosquito Infections by Dengue Viruses During and After Epidemics in a Dengue–endemic Region of Colombia

Dengue vector prevalence and virus infection in a rural area in south India

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