Silent advanced large cell neuroendocrine carcinoma with synchronous adenocarcinoma of the colon: A case report

Baek, Hyeon Seok; Kim, Sang Wook; Lee, Soo Teik; Park, Ho Sung; Seo, Seung Young

doi:10.4251/wjgo.v14.i11.2266

Cited by 3 publications

(5 citation statements)

References 13 publications

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“…These tumors are highly aggressive leading to poor prognostic outcomes with high mortality rates on both 1- and 5-year survival scales. For our patient, the novelty in his treatment and current outcomes are related to the finding of LCNEC incidentally and early prior to the rapid metastasis to additional organs indicated by other reports ( 3 ). In addition, previous reports also indicated a need for further research and data discussing the standardization of treatment for patients diagnosed with LCNECs ( 5 ).…”

Section: Discussionmentioning

confidence: 78%

“…Due to the highly invasive nature of LCNECs, prognosis is unfavorable especially as the cancer is metastatic at the point of diagnosis ( 1 ). Regarding metastasis at the point of diagnosis, one study reported a “silent” version of the cancer, which only presented as anemia despite being stage IV with additional metastasis to the liver, lung, bone, and lymph nodes ( 3 ). Notably, LCNECs can resemble poorly differentiated adenocarcinomas; thus, it is critical to examine neuroendocrine markers to avoid diagnosis prolongation considering the poor prognosis and high metastatic potential ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

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An unexpected case of large cell neuroendocrine carcinoma of the colon: a case report

Nnawuba,

Travis,

Jensen

et al. 2024

J Gastrointest Oncol

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Background Patients presenting with large cell neuroendocrine carcinomas (LCNECs) comprise a small minority of total colon and rectal cancers (1–2%) with poor prognostic outcomes in lieu of late diagnosis and metastasis at the point of diagnosis. Case Description We report a case presentation of a 69-year-old male presenting with diffuse, non-severe upper abdominal pain and a positive at-home colon cancer screening test. At the time of presentation, the patient was negative for constipation or blood in stool. The patient underwent a colonoscopy with biopsy results positive for LCNEC within the proximal ascending colon. A right hemicolectomy was performed with subsequent pathology indicating a poorly differentiated LCNEC with 4/18 positive nodes and final pathology showing stage IIIA (T3, N1, M0) with Ki-67 index at 70%. Post-operative intervention included two cycles of carboplatin and etoposide as well as routine follow-up for labs, imaging, and pharmacological management. Conclusions LCNECs are highly aggressive with poor prognostic outcomes and high mortality rates on both 1- and 5-year survival scales. Prior studies and reports indicated a need for further research and data investigating treatment standardization for patients diagnosed with LCNECs. In lieu of this, this study provides a potential standardized treatment modality combining both European Neuroendocrine Tumor Society (ENETS) and North American Neuroendocrine Tumor Society (NANETS) consensus guidelines.

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Section: Discussionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

An unexpected case of large cell neuroendocrine carcinoma of the colon: a case report

Nnawuba,

Travis,

Jensen

et al. 2024

J Gastrointest Oncol

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“…The ascending colon represents the predominant site common for LCNECCs [ 6 , 8 ], typically presenting with an average tumor size of 7.4 cm [4-11 cm] [ 9 ], Table 1 . Clinical presentation mirrors that of adenocarcinomas [ 10 ], with common symptoms including abdominal pain, constipation, melena, rectal bleeding, tenesmus and diarrhea [ 10 , 11 ]. Complications such as acute intestinal obstruction or colonic perforation may ensue [ 7 , 10 , 12 ], albeit rare cases may remain asymptomatic and be incidentally detected through screening with a fecal occult blood test [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…Contrary to colonic adenocarcinomas, LCNECCs typically exhibit negativity for CK20 [ 10 ], such as in our case. However, isolated cases of CK20-positive LCNECCs have been reported, suggesting a potential common stem cell origin between LCNECCs and adenocarcinomas [ 11 ]. This theory might be supported by the fact that cases of LCNEC with synchronous or metachronous colonic adenocarcinomas were reported [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, isolated cases of CK20-positive LCNECCs have been reported, suggesting a potential common stem cell origin between LCNECCs and adenocarcinomas [ 11 ]. This theory might be supported by the fact that cases of LCNEC with synchronous or metachronous colonic adenocarcinomas were reported [ 11 ]. In the case we present, a synchronous low-grade dysplastic tubular adenoma of the descending colon was diagnosed.…”

Section: Discussionmentioning

confidence: 99%

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Large cell neuroendocrine carcinoma of the colon: An unexpected diagnosis: A case report

Ben Thayer,

Helal,

Khanchel

et al. 2024

International Journal of Surgery Case Reports

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Primary coexisting adenocarcinoma of the colon and neuroendocrine tumor of the duodenum: A case report and review of the literature

Fei,

Wu,

Zhang

et al. 2024

World J Gastrointest Surg

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BACKGROUND Neuroendocrine tumors (NETs) arise from the body’s diffuse endocrine system. Coexisting primary adenocarcinoma of the colon and NETs of the duodenum (D-NETs) is a rare occurrence in clinical practice. The classification and treatment criteria for D-NETs combined with a second primary cancer have not yet been determined. CASE SUMMARY We report the details of a case involving female patient with coexisting primary adenocarcinoma of the colon and a D-NET diagnosed by imaging and surgical specimens. The tumors were treated by surgery and four courses of chemotherapy. The patient achieved a favorable clinical prognosis. CONCLUSION Coexisting primary adenocarcinoma of the colon and D-NET were diagnosed by imaging, laboratory indicators, and surgical specimens. Surgical resection combined with chemotherapy was a safe, clinically effective, and cost-effective treatment.

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Silent advanced large cell neuroendocrine carcinoma with synchronous adenocarcinoma of the colon: A case report

Cited by 3 publications

References 13 publications

An unexpected case of large cell neuroendocrine carcinoma of the colon: a case report

An unexpected case of large cell neuroendocrine carcinoma of the colon: a case report

Large cell neuroendocrine carcinoma of the colon: An unexpected diagnosis: A case report

Primary coexisting adenocarcinoma of the colon and neuroendocrine tumor of the duodenum: A case report and review of the literature

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