Silencing vascular endothelial growth factor C increases the radiosensitivity in nasopharyngeal carcinoma CNE‐2 cells

Wang, Feng; Peng, Lisha; Wang, Yong; Liu, Xiaodong

doi:10.1002/jcb.29352

Cited by 6 publications

(6 citation statements)

References 18 publications

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“…VEGF has been proved to be involved in the occurrence and development of tumors, and is closely related to the prognosis of patients (Siemann, Chaplin, and Horsman 2017). In recent years, many studies have found that inhibiting VEGF expression can improve the sensitivity of many types of cancer to radiotherapy (Chen et Wang et al 2020). In this study, we also found that siRNA knocks down VEGF expression in ESCC cell line to signi cantly inhibit the growth and proliferation of cells after radiotherapy, which is similar to Chen's research results (Chen et al 2015).…”

Section: Discussionsupporting

confidence: 88%

“…Furthermore, VEGF is found to have relaitionship with radioresistance in solid tumors recent years (Buckley et al 2020). In the study of Wang et al (Wang et al 2020), VEGF-C stable and silent nasopharyngeal carcinoma cells were established, and it was found that combined radiotherapy signi cantly inhibited the proliferation and growth ability, and induced nasopharyngeal carcinoma. It makes cell apoptosis and DNA damage.…”

Section: Introductionmentioning

confidence: 99%

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Role of vascular endothelial growth factor in radiotherapy resistance to esophageal squamous cell carcinoma

et al. 2022

J Cancer Res Clin Oncol

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Vascular endothelial growth factor(VEGF) is related to the radiation resistance of tumors, resulting in the failure of tumor radiotherapy. The purpose of this study was to discuss the role of VEGF in radiotherapy resistance of esophageal squamous cell carcinoma(ESCC). We used the VEGF kit by ELISA to detect the serum VEGF level of ESCC patients who only received radiotherapy. The expression of VEGF in ESCC cells after siRNA treatment was veri ed by Western blot. The sensitivity of ESCC cells to radiation after knocking down VEGF was analyzed by Clonogenic assay and Cell counting kit(CCK-8). The results showed that the level of serum VEGF in patients with ESCC before and after radiotherapy was related to the clinical response, and it was con rmed that knocking down the expression of VEGF in ESCC cells improved the sensitivity to radiation.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Role of vascular endothelial growth factor in radiotherapy resistance to esophageal squamous cell carcinoma

et al. 2022

J Cancer Res Clin Oncol

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“…IL11RA encodes the IL-11 receptor, and mutations in this gene cause autosomal recessive Crouzon‐like craniosynostosis [ 54 ] and affect thymus immune function [ 55 ]. Vascular endothelial growth factor C ( VEGFC ) is a determinant of lymphatic vessel density, tumor staging, and lymph node metastasis, and is associated with the failure of nasopharyngeal carcinoma to respond to radiotherapy [ 56 ]. Autophagy related 10 ( ATG10 ) is a critical gene for autophagy and cancer, and there is increasing evidence for the importance of autophagy-related genes in the maintenance, therapy, and pathogenesis of cancer [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

Genomic variations and signatures of selection in Wuhua yellow chicken

Weng

et al. 2020

PLoS ONE

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Wuhua yellow chicken (WHYC) is an important traditional yellow-feathered chicken from China, which is characterized by its white tail feathers, white flight feathers, and strong disease resistance. However, the genomic basis of these unique traits associated with WHYC is poorly understood. In this study, whole-genome resequencing was performed with an average coverage of 20.77-fold to investigate heritable variation and identify selection signals in WHYC. Reads were mapped onto the chicken reference genome (Galgal5) with a coverage of 85.95%. After quality control, 11,953,471 single nucleotide polymorphisms and 1,069,574 insertion/deletions were obtained. In addition, 41,408 structural variants and 33,278 copy number variants were found. Comparative genomic analysis of WHYC and other yellow-feathered chicken breeds showed that selected regions were enriched in genes involved in transport and catabolism, immune system, infectious diseases, signal transduction, and signaling molecules and interactions. Several genes associated with disease resistance were also identified, including IFNA , IFNB , CD86 , IL18 , IL11RA , VEGFC , and ATG10 . Furthermore, our results suggest that PMEL and TYRP1 may contribute to the white feather coloring in WHYC. These findings can improve our understanding of the genetic characteristics of WHYC and may contribute to future breed improvement.

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“…High expression of VEGFC is significantly associated with poor prognosis in various malignancies, including lung cancer [ 44 ], gastric cancer [ 45 ], thyroid cancer [ 46 ], colorectal cancer [ 47 ], and HNSCC [ 48 ]. Furthermore, a study showed that silencing VEGFC can increase the radiosensitivity of nasopharyngeal carcinoma CNE-2 cells [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

A Four-Gene Signature Associated with Radioresistance in Head and Neck Squamous Cell Carcinoma Identified by Text Mining and Data Analysis

Zhang

Wang

et al. 2022

Computational and Mathematical Methods in Medicine

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Purpose. Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cancer globally, and radiotherapy plays a crucial part in its treatment. This study was designed to identify potential genes related to radiation resistance in HNSCC. Method. We first used text mining to obtain common genes related to radiotherapy resistance and HNSCC in published articles. Functional enrichment analyses were conducted to identify the significantly enriched pathways and genes. Protein and protein interactions were performed, and the most significant gene modules were determined; then, genes in the gene modules were validated at transcriptional levels and overall survival. Gene set variation analysis (GSVA) score was calculated, and the association between GSVA score and survival/pathway was estimated. Immune cell infiltration, methylation, and genetic alteration analysis of these genes was conducted in HNSCC patients. Finally, potential sensitive anticancer drugs related to target genes were obtained. Result. We identified 583 common genes through text mining. After further validation, a four-gene signature (EPHB2, SPP1, SERPINE1, and VEGFC) was constructed. The patients with higher GSVA scores have a worse prognosis than those with lower GSVA scores. Differences in methylation of these four genes in HNSCC tumor tissue and normal tissue were compared, with higher methylation levels of EBPH2 and SPP1 in normal tissue and higher methylation levels of SERPINE1 in the tumor. Immune cell infiltration revealed that the increased expression of these genes was closely related to the infiltration level of CD4+ T cell, neutrophil, macrophage, and dendritic cell. Thirty drugs, including 22 positively and eight negatively correlated drugs that most correlated with related genes, were available for treating HNSCC. Conclusion. In this study, we identified four potential genes as well as corresponding drugs that might be related to radioresistance in HNSCC patients. These candidate genes may provide a promising avenue to further elevate radiotherapy efficacy.

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Silencing vascular endothelial growth factor C increases the radiosensitivity in nasopharyngeal carcinoma CNE‐2 cells

Cited by 6 publications

References 18 publications

Role of vascular endothelial growth factor in radiotherapy resistance to esophageal squamous cell carcinoma

Role of vascular endothelial growth factor in radiotherapy resistance to esophageal squamous cell carcinoma

Genomic variations and signatures of selection in Wuhua yellow chicken

A Four-Gene Signature Associated with Radioresistance in Head and Neck Squamous Cell Carcinoma Identified by Text Mining and Data Analysis

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