Silencing the FABP3 gene in insulin-secreting cells reduces fatty acid uptake and protects against lipotoxicity
Ayman Hyder,
Basma Sheta,
Manar Eissa
et al.
Abstract:Background
Long-term exposure of pancreatic islets to fatty acids (FAs), common in obesity, metabolic syndrome, and type 2 diabetes, leads to a compensatory hyperactivity followed by inflammation, apoptosis, dysfunctional beta cells, and results in insulin dependence of the patient. Restriction of fatty uptake by islet beta cells may protect them from lipotoxicity.
Purpose
Pancreatic islet beta cells express the fatty acid binding protein 3 (FABP3) to bind… Show more
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